High loading of lipophilic compounds in mesoporous silica for improved solubility and dissolution performance

[Display omitted] •Loading mesoporous silica is an excellent formulation approach for lipophilic APIs.•Drug loads of up to 50% (w/w) could be achieved.•Even at high drug loads all tested APIs remained in a non-crystalline form.•Solubility and dissolution increased decisively with increasing drug loa...

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Veröffentlicht in:	International journal of pharmaceutics 2024-04, Vol.654, p.123946-123946, Article 123946
Hauptverfasser:	Benedikt Brenner, Marvin, Wüst, Matthias, Kuentz, Martin, Wagner, Karl G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability improvement Dissolution Drug loading Extracts Mesoporous silica Solubility enhancement
Online-Zugang:	Volltext
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