Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding

Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs) could help sustain such states by coupling slow-timescale molecular signals to neuronal excitability. Brainstem parabrachial nucleus glutamatergic (PBNGlut) neurons regulate sustained brain states such as pain...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2024-05, Vol.112 (9), p.1416-1425.e5
Hauptverfasser:	Singh Alvarado, Jonnathan, Lutas, Andrew, Madara, Joseph C., Isaac, Jeremiah, Lommer, Caroline, Massengill, Crystian, Andermann, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals brain slice imaging Brain Stem - metabolism Brain Stem - physiology calcium imaging cAMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism electrophysiology feeding Feeding Behavior - physiology Female fluorescent biosensor imaging Glutamic Acid - metabolism GPCR in vivo licking Male Mice Mice, Inbred C57BL neuronal activity Neurons - metabolism Neurons - physiology Optogenetics parabrachial nucleus Parabrachial Nucleus - metabolism Parabrachial Nucleus - physiology protein kinase A two-photon microscopy
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