Ozone use in the treatment of subclinical mastitis in dairy cows
This research communication paper addresses the hypothesis that the use of therapeutic alternatives for mastitis, such as intramammary ozone, can cure the disease with lower costs and without harmful residues for human consumption and without formation of microbial resistance like the ones caused by...
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| Veröffentlicht in: | Journal of dairy research 2023-11, Vol.90 (4), p.382-386 |
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| creator | Fuentes, Esther Abihail Achy, Jamile A. da Silva, Davi F. Graboschii, Amanda C. G. Bernardo, Juliana de O. Joaquim, Jean G. Fraga, Angelina B. Escodro, Pierre B. |
| description | This research communication paper addresses the hypothesis that the use of therapeutic alternatives for mastitis, such as intramammary ozone, can cure the disease with lower costs and without harmful residues for human consumption and without formation of microbial resistance like the ones caused by indiscriminate use of antibiotics in dairy farms. The study was performed in 36 mammary quarters from 12 dairy cows with subclinical mastitis grade three. The experimental units were randomly assigned into four groups and each group received a treatment. Treatments comprised (a) 20 μg/ml ozone gas; (b) 40 μg/ml ozone gas; (c) negative control treatment of 12.5 μg/ml ozonated saline and (d) positive control treatment of 100 mg of cephalexin + 100 mg of neomycin + 10 mg of prednisolone, all by intramammary injection. In all quarters, milk was collected before and after the application of treatments for California mastitis test and evaluation of milk composition, somatic cell count, and bacterial cultures. The results indicated that the use of intramammary ozone did have a therapeutic effect, and whilst this was less than that of antibiotics, ozone does confer some advantages. Treated milk had a good composition, the treatment cost was low, milk withdrawal may not be necessary and there is no risk of antibiotic resistance. |
| doi_str_mv | 10.1017/S0022029923000808 |
| format | Article |
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G. ; Bernardo, Juliana de O. ; Joaquim, Jean G. ; Fraga, Angelina B. ; Escodro, Pierre B.</creator><creatorcontrib>Fuentes, Esther Abihail ; Achy, Jamile A. ; da Silva, Davi F. ; Graboschii, Amanda C. G. ; Bernardo, Juliana de O. ; Joaquim, Jean G. ; Fraga, Angelina B. ; Escodro, Pierre B.</creatorcontrib><description>This research communication paper addresses the hypothesis that the use of therapeutic alternatives for mastitis, such as intramammary ozone, can cure the disease with lower costs and without harmful residues for human consumption and without formation of microbial resistance like the ones caused by indiscriminate use of antibiotics in dairy farms. The study was performed in 36 mammary quarters from 12 dairy cows with subclinical mastitis grade three. The experimental units were randomly assigned into four groups and each group received a treatment. Treatments comprised (a) 20 μg/ml ozone gas; (b) 40 μg/ml ozone gas; (c) negative control treatment of 12.5 μg/ml ozonated saline and (d) positive control treatment of 100 mg of cephalexin + 100 mg of neomycin + 10 mg of prednisolone, all by intramammary injection. In all quarters, milk was collected before and after the application of treatments for California mastitis test and evaluation of milk composition, somatic cell count, and bacterial cultures. The results indicated that the use of intramammary ozone did have a therapeutic effect, and whilst this was less than that of antibiotics, ozone does confer some advantages. Treated milk had a good composition, the treatment cost was low, milk withdrawal may not be necessary and there is no risk of antibiotic resistance.</description><identifier>ISSN: 0022-0299</identifier><identifier>EISSN: 1469-7629</identifier><identifier>DOI: 10.1017/S0022029923000808</identifier><identifier>PMID: 38420731</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Anti-Bacterial Agents - analysis ; Antibiotic resistance ; Antibiotics ; Bacteria ; California mastitis test ; Cattle ; Cell Count - veterinary ; Cephalexin ; Chi-square test ; Composition ; Dairy cattle ; Dairy farming ; Dairy farms ; Data analysis ; Female ; Gram-positive bacteria ; Humans ; Laboratories ; Lactation ; Lactose ; Mammary Glands, Animal - microbiology ; Mastitis ; Mastitis, Bovine - microbiology ; Microorganisms ; Milk ; Milk - chemistry ; Neomycin ; Ozone ; Ozone - analysis ; Ozone - therapeutic use ; Prednisolone ; Variables ; Variance analysis</subject><ispartof>Journal of dairy research, 2023-11, Vol.90 (4), p.382-386</ispartof><rights>Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022029923000808/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38420731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuentes, Esther Abihail</creatorcontrib><creatorcontrib>Achy, Jamile A.</creatorcontrib><creatorcontrib>da Silva, Davi F.</creatorcontrib><creatorcontrib>Graboschii, Amanda C. G.</creatorcontrib><creatorcontrib>Bernardo, Juliana de O.</creatorcontrib><creatorcontrib>Joaquim, Jean G.</creatorcontrib><creatorcontrib>Fraga, Angelina B.</creatorcontrib><creatorcontrib>Escodro, Pierre B.</creatorcontrib><title>Ozone use in the treatment of subclinical mastitis in dairy cows</title><title>Journal of dairy research</title><addtitle>Journal of Dairy Research</addtitle><description>This research communication paper addresses the hypothesis that the use of therapeutic alternatives for mastitis, such as intramammary ozone, can cure the disease with lower costs and without harmful residues for human consumption and without formation of microbial resistance like the ones caused by indiscriminate use of antibiotics in dairy farms. The study was performed in 36 mammary quarters from 12 dairy cows with subclinical mastitis grade three. The experimental units were randomly assigned into four groups and each group received a treatment. Treatments comprised (a) 20 μg/ml ozone gas; (b) 40 μg/ml ozone gas; (c) negative control treatment of 12.5 μg/ml ozonated saline and (d) positive control treatment of 100 mg of cephalexin + 100 mg of neomycin + 10 mg of prednisolone, all by intramammary injection. In all quarters, milk was collected before and after the application of treatments for California mastitis test and evaluation of milk composition, somatic cell count, and bacterial cultures. The results indicated that the use of intramammary ozone did have a therapeutic effect, and whilst this was less than that of antibiotics, ozone does confer some advantages. Treated milk had a good composition, the treatment cost was low, milk withdrawal may not be necessary and there is no risk of antibiotic resistance.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>California mastitis test</subject><subject>Cattle</subject><subject>Cell Count - veterinary</subject><subject>Cephalexin</subject><subject>Chi-square test</subject><subject>Composition</subject><subject>Dairy cattle</subject><subject>Dairy farming</subject><subject>Dairy farms</subject><subject>Data analysis</subject><subject>Female</subject><subject>Gram-positive bacteria</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lactation</subject><subject>Lactose</subject><subject>Mammary Glands, Animal - microbiology</subject><subject>Mastitis</subject><subject>Mastitis, Bovine - microbiology</subject><subject>Microorganisms</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Neomycin</subject><subject>Ozone</subject><subject>Ozone - analysis</subject><subject>Ozone - therapeutic use</subject><subject>Prednisolone</subject><subject>Variables</subject><subject>Variance analysis</subject><issn>0022-0299</issn><issn>1469-7629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLxDAUhYMozvj4AW4k4MZN9SZp02SnDL5gYBbquqRJqhn6GJMUGX-9LTMqKK7u4nzn3HsPQicELgiQ_PIRgFKgUlIGAALEDpqSlMsk51TuoukoJ6M-QQchLAEIA8n30YSJlELOyBRdLT661uI-WOxaHF8tjt6q2Ng24q7CoS917VqnVY0bFaKLLoygUc6vse7ewxHaq1Qd7PF2HqLn25un2X0yX9w9zK7niWY0iwkVQmYqyyxYAVJVAEaXwLgRXFGmbZ5q4OMbXImMl1WV0Sw3hjEBJTGlYYfofJO78t1bb0MsGhe0rWvV2q4PBZWMpZzkjA3o2S902fW-Ha4bKZoLSdORIhtK-y4Eb6ti5V2j_LogUIz1Fn_qHTyn2-S-bKz5dnz1OQBsG6qa0jvzYn92_x_7CSJ7gg0</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Fuentes, Esther Abihail</creator><creator>Achy, Jamile A.</creator><creator>da Silva, Davi F.</creator><creator>Graboschii, Amanda C. 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G.</au><au>Bernardo, Juliana de O.</au><au>Joaquim, Jean G.</au><au>Fraga, Angelina B.</au><au>Escodro, Pierre B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ozone use in the treatment of subclinical mastitis in dairy cows</atitle><jtitle>Journal of dairy research</jtitle><addtitle>Journal of Dairy Research</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>90</volume><issue>4</issue><spage>382</spage><epage>386</epage><pages>382-386</pages><issn>0022-0299</issn><eissn>1469-7629</eissn><abstract>This research communication paper addresses the hypothesis that the use of therapeutic alternatives for mastitis, such as intramammary ozone, can cure the disease with lower costs and without harmful residues for human consumption and without formation of microbial resistance like the ones caused by indiscriminate use of antibiotics in dairy farms. The study was performed in 36 mammary quarters from 12 dairy cows with subclinical mastitis grade three. The experimental units were randomly assigned into four groups and each group received a treatment. Treatments comprised (a) 20 μg/ml ozone gas; (b) 40 μg/ml ozone gas; (c) negative control treatment of 12.5 μg/ml ozonated saline and (d) positive control treatment of 100 mg of cephalexin + 100 mg of neomycin + 10 mg of prednisolone, all by intramammary injection. In all quarters, milk was collected before and after the application of treatments for California mastitis test and evaluation of milk composition, somatic cell count, and bacterial cultures. The results indicated that the use of intramammary ozone did have a therapeutic effect, and whilst this was less than that of antibiotics, ozone does confer some advantages. Treated milk had a good composition, the treatment cost was low, milk withdrawal may not be necessary and there is no risk of antibiotic resistance.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>38420731</pmid><doi>10.1017/S0022029923000808</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of dairy research, 2023-11, Vol.90 (4), p.382-386 |
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| subjects | Animals Anti-Bacterial Agents - analysis Antibiotic resistance Antibiotics Bacteria California mastitis test Cattle Cell Count - veterinary Cephalexin Chi-square test Composition Dairy cattle Dairy farming Dairy farms Data analysis Female Gram-positive bacteria Humans Laboratories Lactation Lactose Mammary Glands, Animal - microbiology Mastitis Mastitis, Bovine - microbiology Microorganisms Milk Milk - chemistry Neomycin Ozone Ozone - analysis Ozone - therapeutic use Prednisolone Variables Variance analysis |
| title | Ozone use in the treatment of subclinical mastitis in dairy cows |
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