Mitochondrial derived vesicles‐ Quo Vadis?
Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released...
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description | Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from the mitochondrial sub‐compartments into the cytosol, in response to various triggers. MDVs interact with other organelles such as lysosomes and peroxisomes or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse protein and lipid cargoes and are involved in various functions such as mitochondrial quality control, immunomodulation, energy complementation, and compartmentalization and transport. This review aims to provide a summary of the current knowledge of MDVs biogenesis, release, cargoes, and roles.
Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from mitochondrial sub‐compartments in response to various triggers. MDVs interact with other organelles or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse cargoes and are involved in various functions including mitochondrial quality control, immunomodulation, energy complementation, compartmentalization, and transport. This review summarizes the current knowledge of MDVs formation, cargoes, and roles. |
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Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from mitochondrial sub‐compartments in response to various triggers. MDVs interact with other organelles or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse cargoes and are involved in various functions including mitochondrial quality control, immunomodulation, energy complementation, compartmentalization, and transport. This review summarizes the current knowledge of MDVs formation, cargoes, and roles.</description><identifier>ISSN: 1742-464X</identifier><identifier>ISSN: 1742-4658</identifier><identifier>EISSN: 1742-4658</identifier><identifier>DOI: 10.1111/febs.17103</identifier><identifier>PMID: 38414203</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological Transport ; Cellular manufacture ; Complementation ; Cytosol ; Energy metabolism ; Extracellular Vesicles - genetics ; Extracellular Vesicles - metabolism ; Humans ; Immunomodulation ; Lipids ; Lysosomes ; Lysosomes - metabolism ; membrane ; Mitochondria ; Mitochondria - genetics ; Mitochondria - metabolism ; mitochondrial‐derived vesicles ; Organelles ; Prokaryotes ; Protein transport ; Quality control ; Vesicles</subject><ispartof>The FEBS journal, 2024-11, Vol.291 (21), p.4660-4669</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.</rights><rights>2024 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3933-c5bfd382abd0aabec5a60081c8de5d50efc8d7e2e011bbb251e9a91078e511ce3</citedby><cites>FETCH-LOGICAL-c3933-c5bfd382abd0aabec5a60081c8de5d50efc8d7e2e011bbb251e9a91078e511ce3</cites><orcidid>0000-0003-2951-0656</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ffebs.17103$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ffebs.17103$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38414203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hazan (Ben‐Menachem), Reut</creatorcontrib><creatorcontrib>Pines, Ophry</creatorcontrib><creatorcontrib>Saada, Ann</creatorcontrib><title>Mitochondrial derived vesicles‐ Quo Vadis?</title><title>The FEBS journal</title><addtitle>FEBS J</addtitle><description>Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from the mitochondrial sub‐compartments into the cytosol, in response to various triggers. MDVs interact with other organelles such as lysosomes and peroxisomes or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse protein and lipid cargoes and are involved in various functions such as mitochondrial quality control, immunomodulation, energy complementation, and compartmentalization and transport. This review aims to provide a summary of the current knowledge of MDVs biogenesis, release, cargoes, and roles.
Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from mitochondrial sub‐compartments in response to various triggers. MDVs interact with other organelles or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse cargoes and are involved in various functions including mitochondrial quality control, immunomodulation, energy complementation, compartmentalization, and transport. This review summarizes the current knowledge of MDVs formation, cargoes, and roles.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Cellular manufacture</subject><subject>Complementation</subject><subject>Cytosol</subject><subject>Energy metabolism</subject><subject>Extracellular Vesicles - genetics</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Humans</subject><subject>Immunomodulation</subject><subject>Lipids</subject><subject>Lysosomes</subject><subject>Lysosomes - metabolism</subject><subject>membrane</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>mitochondrial‐derived vesicles</subject><subject>Organelles</subject><subject>Prokaryotes</subject><subject>Protein transport</subject><subject>Quality control</subject><subject>Vesicles</subject><issn>1742-464X</issn><issn>1742-4658</issn><issn>1742-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp90MtKw0AUBuBBFKvVjQ8gATcips7JZJpkJVpaFSoiXnA3zOUEU9KmzjSV7nwEn9EncWpqFy4cDsxZfPwcfkIOgHbAv7McletAApRtkB1I4iiMuzzdXO_xS4vsOjeilPE4y7ZJi6UxxBFlO-T0tphV-rWaGFvIMjBoizmaYI6u0CW6r4_P4L6ugmdpCne-R7ZyWTrcX_1t8jToP_auw-Hd1U3vYhhqljEWaq5yw9JIKkOlVKi57FKagk4NcsMp5n5LMEIKoJSKOGAmM6BJihxAI2uT4yZ3aqu3Gt1MjAunsSzlBKvaiShjfpIUuKdHf-ioqu3EXycYRIzGni3VSaO0rZyzmIupLcbSLgRQsexQLDsUPx16fLiKrNUYzZr-luYBNOC9KHHxT5QY9C8fmtBvjOh7fQ</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Hazan (Ben‐Menachem), Reut</creator><creator>Pines, Ophry</creator><creator>Saada, Ann</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2951-0656</orcidid></search><sort><creationdate>202411</creationdate><title>Mitochondrial derived vesicles‐ Quo Vadis?</title><author>Hazan (Ben‐Menachem), Reut ; 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Mitochondrial‐derived vesicles (MDVs) are single or double membrane‐enclosed vesicles, formed and released from mitochondrial sub‐compartments in response to various triggers. MDVs interact with other organelles or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse cargoes and are involved in various functions including mitochondrial quality control, immunomodulation, energy complementation, compartmentalization, and transport. This review summarizes the current knowledge of MDVs formation, cargoes, and roles.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>38414203</pmid><doi>10.1111/febs.17103</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2951-0656</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biological Transport Cellular manufacture Complementation Cytosol Energy metabolism Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Humans Immunomodulation Lipids Lysosomes Lysosomes - metabolism membrane Mitochondria Mitochondria - genetics Mitochondria - metabolism mitochondrial‐derived vesicles Organelles Prokaryotes Protein transport Quality control Vesicles |
title | Mitochondrial derived vesicles‐ Quo Vadis? |
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