Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest

•CuB impeded HCC growth through inducing DNA damage dependent cell cycle arrest.•CuB did not trigger directly HCC cell death such as necrosis and apoptosis.•CuB functioned through ATM-dependent p53-p21-CDK1 and CHK1-CDC25C pathways. The mortality rate of liver cancer ranks third in the world, and he...

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