Biochemical and Structural Studies of the Carminomycin 4‑O‑Methyltransferase DnrK

Structural and functional studies of the carminomycin 4-O-methyltransferase DnrK are described, with an emphasis on interrogating the acceptor substrate scope of DnrK. Specifically, the evaluation of 100 structurally and functionally diverse natural products and natural product mimetics revealed an...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2024-04, Vol.87 (4), p.798-809
Hauptverfasser:	Jalali, Elnaz, Wang, Fengbin, Overbay, Brooke R., Miller, Mitchell D., Shaaban, Khaled A., Ponomareva, Larissa V., Ye, Qing, Saghaeiannejad-Esfahani, Hoda, Bhardwaj, Minakshi, Steele, Andrew D., Teijaro, Christiana N., Shen, Ben, Van Lanen, Steven G., She, Qing-Bai, Voss, S. Randal, Phillips, George N., Thorson, Jon S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines - chemistry Anthracyclines - pharmacology Biological Products - chemistry Biological Products - pharmacology Humans Methyltransferases - chemistry Methyltransferases - metabolism Molecular Structure Substrate Specificity
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