KAT8/SIRT7‐mediated Fascin‐K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma

Fascin actin‐bundling protein 1 (Fascin) is highly expressed in a variety of cancers, including esophageal squamous cell carcinoma (ESCC), working as an important oncogenic protein and promoting the migration and invasion of cancer cells by bundling F‐actin to facilitate the formation of filopodia a...

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Veröffentlicht in:	The Journal of pathology 2024-05, Vol.263 (1), p.74-88
Hauptverfasser:	Li, Da‐Jia, Cheng, Yin‐Wei, Pan, Jin‐Mei, Guo, Zhen‐Chang, Wang, Shao‐Hong, Huang, Qing‐Feng, Nie, Ping‐Juan, Shi, Wen‐Qi, Xu, Xiu‐E, Wen, Bing, Zhong, Jin‐Ling, Zhang, Zhi‐Da, Wu, Zhi‐Yong, Zhao, Hui, Liao, Lian‐Di, Wu, Jian‐Yi, Zhang, Kai, Dong, Geng, Li, En‐Min, Xu, Li‐Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Actin Actins - metabolism Carrier Proteins Cell Line, Tumor Deacetylation Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Fascin Filopodia F‐actin Histone acetyltransferase Histone Acetyltransferases - metabolism Humans invadopodia KAT8 Lymph nodes Lymphatic Metastasis Lymphatic system Metastases Metastasis Microfilament Proteins Proteins SIRT7 Sirtuins - metabolism Squamous cell carcinoma tumor metastasis
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