Interlinked bi‐stable switches govern the cell fate commitment of embryonic stem cells

The development of embryonic stem (ES) cells to extraembryonic trophectoderm and primitive endoderm lineages manifests distinct steady‐state expression patterns of two key transcription factors—Oct4 and Nanog. How dynamically such kind of steady‐state expressions are maintained remains elusive. Here...

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Veröffentlicht in:	FEBS letters 2024-04, Vol.598 (8), p.915-934
Hauptverfasser:	Giri, Amitava, Kar, Sandip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bifurcation theory Cell Differentiation Cell Lineage - genetics developmental dynamics Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism endoderm Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Models, Biological Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism network motifs Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism stem cells stochastic simulation therapeutics
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