Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses

Abstract Chronic viral hepatitis is caused by hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). Despite different replication strategies, all of these viruses rely on secretion through the host endoplasmic reticulum–Golgi pathway, providing potential host targets for anti...

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Veröffentlicht in:	The Journal of infectious diseases 2024-10, Vol.230 (4), p.970-981
Hauptverfasser:	Tu, Thomas, Ajoyan, Harout, Nur Umami, Rifqiyah, Veeraraghavan, Vaishnavi, Boldbaatar, Delgerbat, Najim, Mustafa Ahmed M, Khan, Anis, Bayoumi, Ali, Ho, Vikki, Eslam, Mohammed, Berg, Thomas, Chan, Henry L Y, George, Jacob, Douglas, Mark W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Cell culture Endoplasmic reticulum Gene polymorphism Golgi apparatus Hepacivirus - genetics Hepacivirus - physiology Hepatitis B Hepatitis B - metabolism Hepatitis B - virology Hepatitis B virus - genetics Hepatitis B virus - physiology Hepatitis C Hepatitis Delta Virus - genetics Hepatitis Delta Virus - physiology Humans Male Membrane Proteins - genetics Membrane Proteins - metabolism Protein folding Secretion Secretory Pathway Virions Virus Release Virus Replication Viruses
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