Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma
The value of platelet characteristics as a prognostic factor in patients with pancreatic adenocarcinoma (PDAC) remains unclear. We assessed the prognostic ability of post-splenectomy thrombocytosis in patients who underwent left pancreatectomy for PDAC. Perioperative platelet count ratio (PPR), defi...
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| Veröffentlicht in: | Journal of clinical medicine 2024-02, Vol.13 (4), p.1050 |
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| creator | Nachmany, Ido Gudmundsdottir, Hallbera Meiri, Hila Eidelman, Pavel Ziv, Ofir Bear, Lior Nevo, Nadav Jacoby, Harel Eshkenazy, Rony Pery, Ron Pencovich, Niv |
| description | The value of platelet characteristics as a prognostic factor in patients with pancreatic adenocarcinoma (PDAC) remains unclear.
We assessed the prognostic ability of post-splenectomy thrombocytosis in patients who underwent left pancreatectomy for PDAC. Perioperative platelet count ratio (PPR), defined as the ratio between the maximum platelet count during the first five days following surgery and the preoperative level, was assessed in relation to long-term outcomes in patients who underwent left pancreatectomy for PDAC between November 2008 and October 2022.
A comparative cohort of 245 patients who underwent pancreaticoduodenectomy for PDAC was also evaluated. The median PPR among 106 patients who underwent left pancreatectomy was 1.4 (IQR1.1, 1.8). Forty-six had a PPR ≥ 1.5 (median 1.9, IQR1.7, 2.4) and 60 had a PPR < 1.5 (median 1.2, IQR1.0, 1.3). Patients with a PPR ≥ 1.5 had increased median overall survival (OS) compared to patients with a PPR < 1.5 (40 months vs. 20 months,
< 0.001). In multivariate analysis, PPR < 1.5 remained a strong predictor of worse OS (HR 2.24,
= 0.008). Among patients who underwent pancreaticoduodenectomy, the median PPR was 1.1 (IQR1.0, 1.3), which was significantly lower compared to patients who underwent left pancreatectomy (
> 0.001) and did not predict OS.
PPR is a biomarker for OS after left pancreatectomy for PDAC. Further studies are warranted to consolidate these findings. |
| doi_str_mv | 10.3390/jcm13041050 |
| format | Article |
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We assessed the prognostic ability of post-splenectomy thrombocytosis in patients who underwent left pancreatectomy for PDAC. Perioperative platelet count ratio (PPR), defined as the ratio between the maximum platelet count during the first five days following surgery and the preoperative level, was assessed in relation to long-term outcomes in patients who underwent left pancreatectomy for PDAC between November 2008 and October 2022.
A comparative cohort of 245 patients who underwent pancreaticoduodenectomy for PDAC was also evaluated. The median PPR among 106 patients who underwent left pancreatectomy was 1.4 (IQR1.1, 1.8). Forty-six had a PPR ≥ 1.5 (median 1.9, IQR1.7, 2.4) and 60 had a PPR < 1.5 (median 1.2, IQR1.0, 1.3). Patients with a PPR ≥ 1.5 had increased median overall survival (OS) compared to patients with a PPR < 1.5 (40 months vs. 20 months,
< 0.001). In multivariate analysis, PPR < 1.5 remained a strong predictor of worse OS (HR 2.24,
= 0.008). Among patients who underwent pancreaticoduodenectomy, the median PPR was 1.1 (IQR1.0, 1.3), which was significantly lower compared to patients who underwent left pancreatectomy (
> 0.001) and did not predict OS.
PPR is a biomarker for OS after left pancreatectomy for PDAC. Further studies are warranted to consolidate these findings.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13041050</identifier><identifier>PMID: 38398363</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Blood ; Blood cell count ; Blood platelets ; Cancer therapies ; Care and treatment ; Lymphatic system ; Lymphocytes ; Medical prognosis ; Methods ; Missing data ; Neutrophils ; Pancreatectomy ; Pancreatic cancer ; Pancreaticoduodenectomy ; Patient outcomes ; Patients ; Perioperative care ; Prognosis ; Splenectomy ; Surgery ; Surgical outcomes ; Survival analysis ; Variables</subject><ispartof>Journal of clinical medicine, 2024-02, Vol.13 (4), p.1050</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-33efd05667db59c0f8c3a9609fb1e026fbf35672df87573ef51ecf9f3f4a06423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38398363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nachmany, Ido</creatorcontrib><creatorcontrib>Gudmundsdottir, Hallbera</creatorcontrib><creatorcontrib>Meiri, Hila</creatorcontrib><creatorcontrib>Eidelman, Pavel</creatorcontrib><creatorcontrib>Ziv, Ofir</creatorcontrib><creatorcontrib>Bear, Lior</creatorcontrib><creatorcontrib>Nevo, Nadav</creatorcontrib><creatorcontrib>Jacoby, Harel</creatorcontrib><creatorcontrib>Eshkenazy, Rony</creatorcontrib><creatorcontrib>Pery, Ron</creatorcontrib><creatorcontrib>Pencovich, Niv</creatorcontrib><title>Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The value of platelet characteristics as a prognostic factor in patients with pancreatic adenocarcinoma (PDAC) remains unclear.
We assessed the prognostic ability of post-splenectomy thrombocytosis in patients who underwent left pancreatectomy for PDAC. Perioperative platelet count ratio (PPR), defined as the ratio between the maximum platelet count during the first five days following surgery and the preoperative level, was assessed in relation to long-term outcomes in patients who underwent left pancreatectomy for PDAC between November 2008 and October 2022.
A comparative cohort of 245 patients who underwent pancreaticoduodenectomy for PDAC was also evaluated. The median PPR among 106 patients who underwent left pancreatectomy was 1.4 (IQR1.1, 1.8). Forty-six had a PPR ≥ 1.5 (median 1.9, IQR1.7, 2.4) and 60 had a PPR < 1.5 (median 1.2, IQR1.0, 1.3). Patients with a PPR ≥ 1.5 had increased median overall survival (OS) compared to patients with a PPR < 1.5 (40 months vs. 20 months,
< 0.001). In multivariate analysis, PPR < 1.5 remained a strong predictor of worse OS (HR 2.24,
= 0.008). Among patients who underwent pancreaticoduodenectomy, the median PPR was 1.1 (IQR1.0, 1.3), which was significantly lower compared to patients who underwent left pancreatectomy (
> 0.001) and did not predict OS.
PPR is a biomarker for OS after left pancreatectomy for PDAC. Further studies are warranted to consolidate these findings.</description><subject>Blood</subject><subject>Blood cell count</subject><subject>Blood platelets</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Methods</subject><subject>Missing data</subject><subject>Neutrophils</subject><subject>Pancreatectomy</subject><subject>Pancreatic cancer</subject><subject>Pancreaticoduodenectomy</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Perioperative care</subject><subject>Prognosis</subject><subject>Splenectomy</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Survival analysis</subject><subject>Variables</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkU1r3DAQhkVpaUKSU-9F0EuhOBl7bMs6Lkv6AQtd8nE2WnkUtNjSVpIX8gf6u6sl2zQtlQ4avTzvMMzL2LsSLhElXG31VCLUJTTwip1WIEQB2OHrF_UJu4hxC_l0XV2V4i07yarssMVT9nNNwfodBZXsnvh6VIlGSnzpZ5f4TVY9XwcarE6Rr7x7KO4oTPx2Dnu7VyNXJlHgKzKJr5XTgbJfJz89cuUGfrsbyR3_xodnxGq-GMh5rYK2zk_qnL0xaox0cXzP2P3n67vl12L1_cu35WJVaBQyFYhkBmjaVgybRmownUYlW5BmUxJUrdkYbFpRDaYTjchwU5I20qCpFbR1hWfs41PfXfA_Zoqpn2zUNI7KkZ9jX0msaqybDjL64R906-fg8nQHCmRb5cX_oR7USL11xqeg9KFpvxBdDTVIeaAu_0PlO9BktXdkbNb_Mnx6MujgYwxk-l2wkwqPfQn9Ifj-RfCZfn8cdd5MNDyzv2PGX055qGc</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Nachmany, Ido</creator><creator>Gudmundsdottir, Hallbera</creator><creator>Meiri, Hila</creator><creator>Eidelman, Pavel</creator><creator>Ziv, Ofir</creator><creator>Bear, Lior</creator><creator>Nevo, Nadav</creator><creator>Jacoby, Harel</creator><creator>Eshkenazy, Rony</creator><creator>Pery, Ron</creator><creator>Pencovich, Niv</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20240201</creationdate><title>Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma</title><author>Nachmany, Ido ; Gudmundsdottir, Hallbera ; Meiri, Hila ; Eidelman, Pavel ; Ziv, Ofir ; Bear, Lior ; Nevo, Nadav ; Jacoby, Harel ; Eshkenazy, Rony ; Pery, Ron ; Pencovich, Niv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-33efd05667db59c0f8c3a9609fb1e026fbf35672df87573ef51ecf9f3f4a06423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood</topic><topic>Blood cell count</topic><topic>Blood platelets</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Methods</topic><topic>Missing data</topic><topic>Neutrophils</topic><topic>Pancreatectomy</topic><topic>Pancreatic cancer</topic><topic>Pancreaticoduodenectomy</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Perioperative care</topic><topic>Prognosis</topic><topic>Splenectomy</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Survival analysis</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nachmany, Ido</creatorcontrib><creatorcontrib>Gudmundsdottir, Hallbera</creatorcontrib><creatorcontrib>Meiri, Hila</creatorcontrib><creatorcontrib>Eidelman, Pavel</creatorcontrib><creatorcontrib>Ziv, Ofir</creatorcontrib><creatorcontrib>Bear, Lior</creatorcontrib><creatorcontrib>Nevo, Nadav</creatorcontrib><creatorcontrib>Jacoby, Harel</creatorcontrib><creatorcontrib>Eshkenazy, Rony</creatorcontrib><creatorcontrib>Pery, Ron</creatorcontrib><creatorcontrib>Pencovich, Niv</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nachmany, Ido</au><au>Gudmundsdottir, Hallbera</au><au>Meiri, Hila</au><au>Eidelman, Pavel</au><au>Ziv, Ofir</au><au>Bear, Lior</au><au>Nevo, Nadav</au><au>Jacoby, Harel</au><au>Eshkenazy, Rony</au><au>Pery, Ron</au><au>Pencovich, Niv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>13</volume><issue>4</issue><spage>1050</spage><pages>1050-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The value of platelet characteristics as a prognostic factor in patients with pancreatic adenocarcinoma (PDAC) remains unclear.
We assessed the prognostic ability of post-splenectomy thrombocytosis in patients who underwent left pancreatectomy for PDAC. Perioperative platelet count ratio (PPR), defined as the ratio between the maximum platelet count during the first five days following surgery and the preoperative level, was assessed in relation to long-term outcomes in patients who underwent left pancreatectomy for PDAC between November 2008 and October 2022.
A comparative cohort of 245 patients who underwent pancreaticoduodenectomy for PDAC was also evaluated. The median PPR among 106 patients who underwent left pancreatectomy was 1.4 (IQR1.1, 1.8). Forty-six had a PPR ≥ 1.5 (median 1.9, IQR1.7, 2.4) and 60 had a PPR < 1.5 (median 1.2, IQR1.0, 1.3). Patients with a PPR ≥ 1.5 had increased median overall survival (OS) compared to patients with a PPR < 1.5 (40 months vs. 20 months,
< 0.001). In multivariate analysis, PPR < 1.5 remained a strong predictor of worse OS (HR 2.24,
= 0.008). Among patients who underwent pancreaticoduodenectomy, the median PPR was 1.1 (IQR1.0, 1.3), which was significantly lower compared to patients who underwent left pancreatectomy (
> 0.001) and did not predict OS.
PPR is a biomarker for OS after left pancreatectomy for PDAC. Further studies are warranted to consolidate these findings.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38398363</pmid><doi>10.3390/jcm13041050</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Blood Blood cell count Blood platelets Cancer therapies Care and treatment Lymphatic system Lymphocytes Medical prognosis Methods Missing data Neutrophils Pancreatectomy Pancreatic cancer Pancreaticoduodenectomy Patient outcomes Patients Perioperative care Prognosis Splenectomy Surgery Surgical outcomes Survival analysis Variables |
| title | Perioperative Platelet Count Ratio Predicts Long-Term Survival after Left Pancreatectomy and Splenectomy for Pancreatic Adenocarcinoma |
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