Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study
Purpose To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC). Methods Between July 2010 and December 2022, 146 patients were recruited. Sarcopenia was assessed using the psoas muscle index. Preoperativ...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2024-06, Vol.55 (2), p.888-899 |
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| creator | Utsumi, Masashi Inagaki, Masaru Kitada, Koji Tokunaga, Naoyuki Yonoki, Kosuke Sakurai, Yuya Okabayashi, Hiroki Hamano, Ryosuke Miyasou, Hideaki Tsunemitsu, Yousuke Otsuka, Shinya |
| description | Purpose
To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC).
Methods
Between July 2010 and December 2022, 146 patients were recruited. Sarcopenia was assessed using the psoas muscle index. Preoperative inflammatory markers were used to calculate the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Cox regression analysis was performed to determine prognostic factors for overall survival (OS) and recurrence-free survival (RFS).
P
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| doi_str_mv | 10.1007/s12029-024-01034-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2932025777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2932025777</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-c185632871afab6c2a08ddb3155dc87af9c06db0ed26b9f44e3c13b25d2712b23</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EglL4AwzII0vAH4mTsJWKLwkEojBbju0Ul8QutoPUgf-OodCRySffc6_uHgCOMDrFCJVnARNE6gyRPEMY0TxjW2CE6xxnjFG2valJtQf2Q1ggxPIC412wR6sc0RLnI_D56N3cuhCNhDMzt6Y1UlipoWvhTHjpltoaAYVVcLYKUfeJu7VtJ_peROdX8F74N-0DNBZemM6I9PXshYxw-h3jz-EEPunoXVhqGc2HhlP36nyEszio1QHYaUUX9OHvOwYvV5fP05vs7uH6djq5yySpq5hJXBWMkqrEohUNk0SgSqmG4qJQsipFW0vEVIO0Iqyp2zzXVGLakEKREpOG0DE4WecuvXsfdIi8N0HqrhNWuyFwUtOksijLMqFkjcq0c_C65Utv-nQWx4h_a-dr7Txp5z_aOUtDx7_5Q9NrtRn585wAugZCatm59nzhBm_Tzf_FfgEHSo8r</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2932025777</pqid></control><display><type>article</type><title>Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study</title><source>SpringerLink Journals</source><creator>Utsumi, Masashi ; Inagaki, Masaru ; Kitada, Koji ; Tokunaga, Naoyuki ; Yonoki, Kosuke ; Sakurai, Yuya ; Okabayashi, Hiroki ; Hamano, Ryosuke ; Miyasou, Hideaki ; Tsunemitsu, Yousuke ; Otsuka, Shinya</creator><creatorcontrib>Utsumi, Masashi ; Inagaki, Masaru ; Kitada, Koji ; Tokunaga, Naoyuki ; Yonoki, Kosuke ; Sakurai, Yuya ; Okabayashi, Hiroki ; Hamano, Ryosuke ; Miyasou, Hideaki ; Tsunemitsu, Yousuke ; Otsuka, Shinya</creatorcontrib><description><![CDATA[Purpose
To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC).
Methods
Between July 2010 and December 2022, 146 patients were recruited. Sarcopenia was assessed using the psoas muscle index. Preoperative inflammatory markers were used to calculate the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Cox regression analysis was performed to determine prognostic factors for overall survival (OS) and recurrence-free survival (RFS).
P
< 0.05 was considered statistically significant.
Results
Sixty-four patients had sarcopenia. Sarcopenia was associated with body mass index (< 22 kg/m
2
), lymph node metastasis, and low PNI (< 42). R1/R2 resection (
P
= 0.02), sarcopenia (
P
< 0.001), lymph node metastasis (
P
= 0.007), intrahepatic cholangiocarcinoma (
P
< 0.001), and low PNI (
P
= 0.01) were independent predictors of OS, while male sex (
P
= 0.04), R1/R2 resection (
P
< 0.001), lymph node metastasis (
P
= 0.005), intrahepatic cholangiocarcinoma (
P
< 0.001), tumor differentiation (other than well;
P
= 0.003), and low PNI (
P
= 0.03) were independent predictors of RFS. Patients were stratified into no sarcopenia and high PNI (≥ 42; A), sarcopenia or low PNI (B), and sarcopenia and low PNI (C) groups. Group C had worse OS than the other two groups (
P
< 0.001 and
P
= 0.02, respectively).
Conclusion
Sarcopenia is associated with the PNI. Sarcopenia and the PNI are independent prognostic factors among patients with resected BTC. Sarcopenia may have better prognostic value when combined with the PNI.]]></description><identifier>ISSN: 1941-6628</identifier><identifier>ISSN: 1941-6636</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-024-01034-6</identifier><identifier>PMID: 38403714</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2024-06, Vol.55 (2), p.888-899</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-c185632871afab6c2a08ddb3155dc87af9c06db0ed26b9f44e3c13b25d2712b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-024-01034-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-024-01034-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38403714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Utsumi, Masashi</creatorcontrib><creatorcontrib>Inagaki, Masaru</creatorcontrib><creatorcontrib>Kitada, Koji</creatorcontrib><creatorcontrib>Tokunaga, Naoyuki</creatorcontrib><creatorcontrib>Yonoki, Kosuke</creatorcontrib><creatorcontrib>Sakurai, Yuya</creatorcontrib><creatorcontrib>Okabayashi, Hiroki</creatorcontrib><creatorcontrib>Hamano, Ryosuke</creatorcontrib><creatorcontrib>Miyasou, Hideaki</creatorcontrib><creatorcontrib>Tsunemitsu, Yousuke</creatorcontrib><creatorcontrib>Otsuka, Shinya</creatorcontrib><title>Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description><![CDATA[Purpose
To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC).
Methods
Between July 2010 and December 2022, 146 patients were recruited. Sarcopenia was assessed using the psoas muscle index. Preoperative inflammatory markers were used to calculate the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Cox regression analysis was performed to determine prognostic factors for overall survival (OS) and recurrence-free survival (RFS).
P
< 0.05 was considered statistically significant.
Results
Sixty-four patients had sarcopenia. Sarcopenia was associated with body mass index (< 22 kg/m
2
), lymph node metastasis, and low PNI (< 42). R1/R2 resection (
P
= 0.02), sarcopenia (
P
< 0.001), lymph node metastasis (
P
= 0.007), intrahepatic cholangiocarcinoma (
P
< 0.001), and low PNI (
P
= 0.01) were independent predictors of OS, while male sex (
P
= 0.04), R1/R2 resection (
P
< 0.001), lymph node metastasis (
P
= 0.005), intrahepatic cholangiocarcinoma (
P
< 0.001), tumor differentiation (other than well;
P
= 0.003), and low PNI (
P
= 0.03) were independent predictors of RFS. Patients were stratified into no sarcopenia and high PNI (≥ 42; A), sarcopenia or low PNI (B), and sarcopenia and low PNI (C) groups. Group C had worse OS than the other two groups (
P
< 0.001 and
P
= 0.02, respectively).
Conclusion
Sarcopenia is associated with the PNI. Sarcopenia and the PNI are independent prognostic factors among patients with resected BTC. Sarcopenia may have better prognostic value when combined with the PNI.]]></description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EglL4AwzII0vAH4mTsJWKLwkEojBbju0Ul8QutoPUgf-OodCRySffc6_uHgCOMDrFCJVnARNE6gyRPEMY0TxjW2CE6xxnjFG2valJtQf2Q1ggxPIC412wR6sc0RLnI_D56N3cuhCNhDMzt6Y1UlipoWvhTHjpltoaAYVVcLYKUfeJu7VtJ_peROdX8F74N-0DNBZemM6I9PXshYxw-h3jz-EEPunoXVhqGc2HhlP36nyEszio1QHYaUUX9OHvOwYvV5fP05vs7uH6djq5yySpq5hJXBWMkqrEohUNk0SgSqmG4qJQsipFW0vEVIO0Iqyp2zzXVGLakEKREpOG0DE4WecuvXsfdIi8N0HqrhNWuyFwUtOksijLMqFkjcq0c_C65Utv-nQWx4h_a-dr7Txp5z_aOUtDx7_5Q9NrtRn585wAugZCatm59nzhBm_Tzf_FfgEHSo8r</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Utsumi, Masashi</creator><creator>Inagaki, Masaru</creator><creator>Kitada, Koji</creator><creator>Tokunaga, Naoyuki</creator><creator>Yonoki, Kosuke</creator><creator>Sakurai, Yuya</creator><creator>Okabayashi, Hiroki</creator><creator>Hamano, Ryosuke</creator><creator>Miyasou, Hideaki</creator><creator>Tsunemitsu, Yousuke</creator><creator>Otsuka, Shinya</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study</title><author>Utsumi, Masashi ; Inagaki, Masaru ; Kitada, Koji ; Tokunaga, Naoyuki ; Yonoki, Kosuke ; Sakurai, Yuya ; Okabayashi, Hiroki ; Hamano, Ryosuke ; Miyasou, Hideaki ; Tsunemitsu, Yousuke ; Otsuka, Shinya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-c185632871afab6c2a08ddb3155dc87af9c06db0ed26b9f44e3c13b25d2712b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Utsumi, Masashi</creatorcontrib><creatorcontrib>Inagaki, Masaru</creatorcontrib><creatorcontrib>Kitada, Koji</creatorcontrib><creatorcontrib>Tokunaga, Naoyuki</creatorcontrib><creatorcontrib>Yonoki, Kosuke</creatorcontrib><creatorcontrib>Sakurai, Yuya</creatorcontrib><creatorcontrib>Okabayashi, Hiroki</creatorcontrib><creatorcontrib>Hamano, Ryosuke</creatorcontrib><creatorcontrib>Miyasou, Hideaki</creatorcontrib><creatorcontrib>Tsunemitsu, Yousuke</creatorcontrib><creatorcontrib>Otsuka, Shinya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Utsumi, Masashi</au><au>Inagaki, Masaru</au><au>Kitada, Koji</au><au>Tokunaga, Naoyuki</au><au>Yonoki, Kosuke</au><au>Sakurai, Yuya</au><au>Okabayashi, Hiroki</au><au>Hamano, Ryosuke</au><au>Miyasou, Hideaki</au><au>Tsunemitsu, Yousuke</au><au>Otsuka, Shinya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>55</volume><issue>2</issue><spage>888</spage><epage>899</epage><pages>888-899</pages><issn>1941-6628</issn><issn>1941-6636</issn><eissn>1941-6636</eissn><abstract><![CDATA[Purpose
To evaluate the prognostic significance of sarcopenia and systemic inflammatory markers in patients with surgically resected biliary tract cancer (BTC).
Methods
Between July 2010 and December 2022, 146 patients were recruited. Sarcopenia was assessed using the psoas muscle index. Preoperative inflammatory markers were used to calculate the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Cox regression analysis was performed to determine prognostic factors for overall survival (OS) and recurrence-free survival (RFS).
P
< 0.05 was considered statistically significant.
Results
Sixty-four patients had sarcopenia. Sarcopenia was associated with body mass index (< 22 kg/m
2
), lymph node metastasis, and low PNI (< 42). R1/R2 resection (
P
= 0.02), sarcopenia (
P
< 0.001), lymph node metastasis (
P
= 0.007), intrahepatic cholangiocarcinoma (
P
< 0.001), and low PNI (
P
= 0.01) were independent predictors of OS, while male sex (
P
= 0.04), R1/R2 resection (
P
< 0.001), lymph node metastasis (
P
= 0.005), intrahepatic cholangiocarcinoma (
P
< 0.001), tumor differentiation (other than well;
P
= 0.003), and low PNI (
P
= 0.03) were independent predictors of RFS. Patients were stratified into no sarcopenia and high PNI (≥ 42; A), sarcopenia or low PNI (B), and sarcopenia and low PNI (C) groups. Group C had worse OS than the other two groups (
P
< 0.001 and
P
= 0.02, respectively).
Conclusion
Sarcopenia is associated with the PNI. Sarcopenia and the PNI are independent prognostic factors among patients with resected BTC. Sarcopenia may have better prognostic value when combined with the PNI.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>38403714</pmid><doi>10.1007/s12029-024-01034-6</doi><tpages>12</tpages></addata></record> |
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| subjects | Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Radiotherapy |
| title | Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study |
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