Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models
Objectives Skin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflamma...
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| Veröffentlicht in: | Skin research and technology 2024-03, Vol.30 (3), p.e13615-n/a |
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| creator | Park, Kyung Duck Kwack, Mi Hee Yoon, Hyo Jin Lee, Weon Ju |
| description | Objectives
Skin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflammation. Thus, addressing this problem is urgent.
Methods
Skin barrier‐disrupted mouse models were induced by two methods using acetone application or tape‐stripping. This study investigated the antioxidative and anti‐inflammatory properties of the Siegesbeckia herba extract (SHE) on PM‐induced changes in skin barrier‐disrupted mouse models. To examine changes in skin water content, inflammatory cytokines, and keratinocyte differentiation markers, mouse models were treated with vehicle 100 μL, PM10 100 μL (100 μg/mL), SHE 100 μL, or PM10 100 μL (100 μg/mL) plus SHE 100 μL.
Results
SHE preserved skin hydration in the skin barrier‐disrupted mouse models regardless of the presence of PM10. SHE also inhibited the upregulation of inflammatory cytokines such as interleukin (IL)‐1β, IL‐4, IL‐6, IL‐8, and tumor necrosis factor‐α and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier‐disrupted mouse models.
Conclusions
This study elucidated the therapeutic effects of SHE against PM10 in skin barrier‐disrupted mouse models. |
| doi_str_mv | 10.1111/srt.13615 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2932023727</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2987176222</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3885-6e5d97728a1435c9feeb3a59201ab0fe0a4306b4312a1e1cda6cffa1fbb278293</originalsourceid><addsrcrecordid>eNp10c9OFTEUBvCGaOCKLngB08QNLAbOae_8WxoCaoLRACbuJqedUyzM3Lm0nSA7H8Fn9EmsXnBhQhft5tcvJ-cTYg_hEPM5iiEdoq6w3BILrAAKaJbVM7GAFtqiLtXXHfEixmsAKFvU22JHN7pFUOVCxBPn2KYoJycvPF9xNGxvPMlvHAxJ_p4C2STpivwqJrmmkLydB0osR0qJg0SQ-58_IhxIv5LxJl-GQvAcfv342fsY5nXiXo7THPOXqechvhTPHQ2RXz28u-LL6cnl8fvi7NO7D8dvzwqrm6YsKi77tq5VQ7jUpW0ds9FUtgqQDDgGWmqozFKjImS0PVXWOUJnjKob1epdsb_JXYfpduaYutFHy8NAK87jdJkoULpWdaZv_qPX0xxWebqsmhrrSimV1cFG2TDFGNh16-BHCvcdQveniS430f1tItvXD4mzGbn_Jx9Xn8HRBtz5ge-fTuouzi83kb8Bmd6TZQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2987176222</pqid></control><display><type>article</type><title>Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Park, Kyung Duck ; Kwack, Mi Hee ; Yoon, Hyo Jin ; Lee, Weon Ju</creator><creatorcontrib>Park, Kyung Duck ; Kwack, Mi Hee ; Yoon, Hyo Jin ; Lee, Weon Ju</creatorcontrib><description>Objectives
Skin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflammation. Thus, addressing this problem is urgent.
Methods
Skin barrier‐disrupted mouse models were induced by two methods using acetone application or tape‐stripping. This study investigated the antioxidative and anti‐inflammatory properties of the Siegesbeckia herba extract (SHE) on PM‐induced changes in skin barrier‐disrupted mouse models. To examine changes in skin water content, inflammatory cytokines, and keratinocyte differentiation markers, mouse models were treated with vehicle 100 μL, PM10 100 μL (100 μg/mL), SHE 100 μL, or PM10 100 μL (100 μg/mL) plus SHE 100 μL.
Results
SHE preserved skin hydration in the skin barrier‐disrupted mouse models regardless of the presence of PM10. SHE also inhibited the upregulation of inflammatory cytokines such as interleukin (IL)‐1β, IL‐4, IL‐6, IL‐8, and tumor necrosis factor‐α and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier‐disrupted mouse models.
Conclusions
This study elucidated the therapeutic effects of SHE against PM10 in skin barrier‐disrupted mouse models.</description><identifier>ISSN: 0909-752X</identifier><identifier>ISSN: 1600-0846</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.13615</identifier><identifier>PMID: 38391025</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animal models ; Animals ; Antigens, Differentiation ; Cytokines ; Differentiation ; Hydration ; Inflammation ; Mice ; Moisture content ; Particulate emissions ; Particulate matter ; Particulate Matter - toxicity ; Siegesbeckia herba extract ; Sigesbeckia ; Skin ; Skin barrier disruption ; Water ; Water content ; Water loss ; Xerosis</subject><ispartof>Skin research and technology, 2024-03, Vol.30 (3), p.e13615-n/a</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2024 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-6e5d97728a1435c9feeb3a59201ab0fe0a4306b4312a1e1cda6cffa1fbb278293</citedby><cites>FETCH-LOGICAL-c3885-6e5d97728a1435c9feeb3a59201ab0fe0a4306b4312a1e1cda6cffa1fbb278293</cites><orcidid>0000-0002-7381-6532 ; 0000-0001-5708-1305 ; 0000-0002-6067-7262 ; 0009-0006-4142-8275</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsrt.13615$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsrt.13615$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,11542,27903,27904,45553,45554,46031,46455</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38391025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Kyung Duck</creatorcontrib><creatorcontrib>Kwack, Mi Hee</creatorcontrib><creatorcontrib>Yoon, Hyo Jin</creatorcontrib><creatorcontrib>Lee, Weon Ju</creatorcontrib><title>Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Objectives
Skin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflammation. Thus, addressing this problem is urgent.
Methods
Skin barrier‐disrupted mouse models were induced by two methods using acetone application or tape‐stripping. This study investigated the antioxidative and anti‐inflammatory properties of the Siegesbeckia herba extract (SHE) on PM‐induced changes in skin barrier‐disrupted mouse models. To examine changes in skin water content, inflammatory cytokines, and keratinocyte differentiation markers, mouse models were treated with vehicle 100 μL, PM10 100 μL (100 μg/mL), SHE 100 μL, or PM10 100 μL (100 μg/mL) plus SHE 100 μL.
Results
SHE preserved skin hydration in the skin barrier‐disrupted mouse models regardless of the presence of PM10. SHE also inhibited the upregulation of inflammatory cytokines such as interleukin (IL)‐1β, IL‐4, IL‐6, IL‐8, and tumor necrosis factor‐α and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier‐disrupted mouse models.
Conclusions
This study elucidated the therapeutic effects of SHE against PM10 in skin barrier‐disrupted mouse models.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antigens, Differentiation</subject><subject>Cytokines</subject><subject>Differentiation</subject><subject>Hydration</subject><subject>Inflammation</subject><subject>Mice</subject><subject>Moisture content</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - toxicity</subject><subject>Siegesbeckia herba extract</subject><subject>Sigesbeckia</subject><subject>Skin</subject><subject>Skin barrier disruption</subject><subject>Water</subject><subject>Water content</subject><subject>Water loss</subject><subject>Xerosis</subject><issn>0909-752X</issn><issn>1600-0846</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp10c9OFTEUBvCGaOCKLngB08QNLAbOae_8WxoCaoLRACbuJqedUyzM3Lm0nSA7H8Fn9EmsXnBhQhft5tcvJ-cTYg_hEPM5iiEdoq6w3BILrAAKaJbVM7GAFtqiLtXXHfEixmsAKFvU22JHN7pFUOVCxBPn2KYoJycvPF9xNGxvPMlvHAxJ_p4C2STpivwqJrmmkLydB0osR0qJg0SQ-58_IhxIv5LxJl-GQvAcfv342fsY5nXiXo7THPOXqechvhTPHQ2RXz28u-LL6cnl8fvi7NO7D8dvzwqrm6YsKi77tq5VQ7jUpW0ds9FUtgqQDDgGWmqozFKjImS0PVXWOUJnjKob1epdsb_JXYfpduaYutFHy8NAK87jdJkoULpWdaZv_qPX0xxWebqsmhrrSimV1cFG2TDFGNh16-BHCvcdQveniS430f1tItvXD4mzGbn_Jx9Xn8HRBtz5ge-fTuouzi83kb8Bmd6TZQ</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Park, Kyung Duck</creator><creator>Kwack, Mi Hee</creator><creator>Yoon, Hyo Jin</creator><creator>Lee, Weon Ju</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7381-6532</orcidid><orcidid>https://orcid.org/0000-0001-5708-1305</orcidid><orcidid>https://orcid.org/0000-0002-6067-7262</orcidid><orcidid>https://orcid.org/0009-0006-4142-8275</orcidid></search><sort><creationdate>202403</creationdate><title>Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models</title><author>Park, Kyung Duck ; Kwack, Mi Hee ; Yoon, Hyo Jin ; Lee, Weon Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-6e5d97728a1435c9feeb3a59201ab0fe0a4306b4312a1e1cda6cffa1fbb278293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antigens, Differentiation</topic><topic>Cytokines</topic><topic>Differentiation</topic><topic>Hydration</topic><topic>Inflammation</topic><topic>Mice</topic><topic>Moisture content</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - toxicity</topic><topic>Siegesbeckia herba extract</topic><topic>Sigesbeckia</topic><topic>Skin</topic><topic>Skin barrier disruption</topic><topic>Water</topic><topic>Water content</topic><topic>Water loss</topic><topic>Xerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Kyung Duck</creatorcontrib><creatorcontrib>Kwack, Mi Hee</creatorcontrib><creatorcontrib>Yoon, Hyo Jin</creatorcontrib><creatorcontrib>Lee, Weon Ju</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Kyung Duck</au><au>Kwack, Mi Hee</au><au>Yoon, Hyo Jin</au><au>Lee, Weon Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2024-03</date><risdate>2024</risdate><volume>30</volume><issue>3</issue><spage>e13615</spage><epage>n/a</epage><pages>e13615-n/a</pages><issn>0909-752X</issn><issn>1600-0846</issn><eissn>1600-0846</eissn><abstract>Objectives
Skin barrier disruption is a significant problem of the older population in an aging society. It is characterized by increased transepidermal water loss and decreased skin water content, and particulate matter (PM) is a social issue that can contribute to the exacerbation of skin inflammation. Thus, addressing this problem is urgent.
Methods
Skin barrier‐disrupted mouse models were induced by two methods using acetone application or tape‐stripping. This study investigated the antioxidative and anti‐inflammatory properties of the Siegesbeckia herba extract (SHE) on PM‐induced changes in skin barrier‐disrupted mouse models. To examine changes in skin water content, inflammatory cytokines, and keratinocyte differentiation markers, mouse models were treated with vehicle 100 μL, PM10 100 μL (100 μg/mL), SHE 100 μL, or PM10 100 μL (100 μg/mL) plus SHE 100 μL.
Results
SHE preserved skin hydration in the skin barrier‐disrupted mouse models regardless of the presence of PM10. SHE also inhibited the upregulation of inflammatory cytokines such as interleukin (IL)‐1β, IL‐4, IL‐6, IL‐8, and tumor necrosis factor‐α and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier‐disrupted mouse models.
Conclusions
This study elucidated the therapeutic effects of SHE against PM10 in skin barrier‐disrupted mouse models.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38391025</pmid><doi>10.1111/srt.13615</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7381-6532</orcidid><orcidid>https://orcid.org/0000-0001-5708-1305</orcidid><orcidid>https://orcid.org/0000-0002-6067-7262</orcidid><orcidid>https://orcid.org/0009-0006-4142-8275</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal models Animals Antigens, Differentiation Cytokines Differentiation Hydration Inflammation Mice Moisture content Particulate emissions Particulate matter Particulate Matter - toxicity Siegesbeckia herba extract Sigesbeckia Skin Skin barrier disruption Water Water content Water loss Xerosis |
| title | Effects of Siegesbeckia herba extract against particulate matter 10 (PM10) in skin barrier‐disrupted mouse models |
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