Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health
Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. Substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for...
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| Veröffentlicht in: | International journal of molecular sciences 2024-02, Vol.25 (4), p.2324 |
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| creator | Mascarenhas, Caio Sousa, Ana C A Rato, Luís |
| description | Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. Substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for their ability to induce weight gain, often accompanied by hormonal alterations that can adversely impact male fertility. Indeed, research has supplied evidence underscoring the crucial role of obesogens and therapeutic agents in the normal functioning of the male reproductive system. Notably, sperm count and various semen parameters have been closely linked to a range of environmental and nutritional factors, including chemicals and pharmacological agents exhibiting obesogenic properties. This review aimed to explore studies focused on analyzing male fertility parameters, delving into the intricacies of sperm quality, and elucidating the direct and adverse effects that pharmacological agents may have on these aspects. |
| doi_str_mv | 10.3390/ijms25042324 |
| format | Article |
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| subjects | Alfuzosin Anticonvulsants Antihypertensive drugs Endocrine disruptors Endocrine Disruptors - toxicity Health aspects Humans Infertility, Male Insulin resistance Kinases Male Obesity Pharmaceutical Preparations Pharmaceuticals Reproductive Health Semen Spermatozoa Type 2 diabetes |
| title | Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health |
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