Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer

Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer

Abstract OBJECTIVES The timing of preoperative imaging in patients with lung cancer is a debated topic, as there are limited data on cancer progression during the interval between clinical staging by imaging and pathological staging after resection. We quantified disease progression during this inte...

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Veröffentlicht in:European journal of cardio-thoracic surgery 2024-02, Vol.65 (2)
Hauptverfasser: Barcelos, Rafael R, Sugarbaker, Evert, Kennedy, Kelvin F, McAllister, Miles, Kim, Sangmin, Herrera-Zamora, Julio, Leo, Rachel, Swanson, Scott, Ugalde Figueroa, Paula
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container_title European journal of cardio-thoracic surgery
container_volume 65
creator Barcelos, Rafael R
Sugarbaker, Evert
Kennedy, Kelvin F
McAllister, Miles
Kim, Sangmin
Herrera-Zamora, Julio
Leo, Rachel
Swanson, Scott
Ugalde Figueroa, Paula
description Abstract OBJECTIVES The timing of preoperative imaging in patients with lung cancer is a debated topic, as there are limited data on cancer progression during the interval between clinical staging by imaging and pathological staging after resection. We quantified disease progression during this interval in patients with early stage non-small-cell lung cancer (NSCLC) to better understand if its length impacts upstaging. METHODS We retrospectively reviewed our institutional database to identify patients who underwent surgery for clinically staged T1N0M0 NSCLC from January 2015 through September 2022. Tumour upstaging between chest computed tomography (CT) and surgery were analysed as a function of time (
doi_str_mv 10.1093/ejcts/ezae057
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We quantified disease progression during this interval in patients with early stage non-small-cell lung cancer (NSCLC) to better understand if its length impacts upstaging. METHODS We retrospectively reviewed our institutional database to identify patients who underwent surgery for clinically staged T1N0M0 NSCLC from January 2015 through September 2022. Tumour upstaging between chest computed tomography (CT) and surgery were analysed as a function of time (&lt;30, 30–59, ≥60 days) for different nodule subtypes. We analysed data across 3 timeframes using Pearson’s chi-squared and analysis of variance tests. RESULTS During the study period, 622 patients underwent surgery for clinically staged T1N0M0 NSCLC. CT-to-surgery interval was &lt;30 days in 228 (36.7%), 30–59 days in 242 (38.9%) and ≥60 days in 152 (24.4%) with no differences in patient or nodule characteristics observed between these groups. T-stage increased in 346 patients (55.6%) between CT imaging and surgery. Among these patients, 126 (36.4%) had ground-glass nodules, 147 (42.5%) had part-solid nodules and 73 (21.1%) had solid nodules. CT-to-surgery interval length was not associated with upstaging of any nodule subtype (full-cohort, P = 0.903; ground-glass, P = 0.880; part-solid, P = 0.858; solid, P = 0.959). CONCLUSIONS This single-centre experience suggests no significant association between tumour upstaging and time from imaging to lung resection in patients with clinical stage IA NSCLC. Further studies are needed to better understand the risk factors for upstaging. Lung cancer is the second most common cancer in both men and women in the USA (excluding non-melanoma skin cancer) and the most lethal neoplasm [1].</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezae057</identifier><identifier>PMID: 38407382</identifier><language>eng</language><publisher>Germany: Oxford University Press</publisher><ispartof>European journal of cardio-thoracic surgery, 2024-02, Vol.65 (2)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4284-444X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38407382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barcelos, Rafael R</creatorcontrib><creatorcontrib>Sugarbaker, Evert</creatorcontrib><creatorcontrib>Kennedy, Kelvin F</creatorcontrib><creatorcontrib>McAllister, Miles</creatorcontrib><creatorcontrib>Kim, Sangmin</creatorcontrib><creatorcontrib>Herrera-Zamora, Julio</creatorcontrib><creatorcontrib>Leo, Rachel</creatorcontrib><creatorcontrib>Swanson, Scott</creatorcontrib><creatorcontrib>Ugalde Figueroa, Paula</creatorcontrib><title>Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><description>Abstract OBJECTIVES The timing of preoperative imaging in patients with lung cancer is a debated topic, as there are limited data on cancer progression during the interval between clinical staging by imaging and pathological staging after resection. We quantified disease progression during this interval in patients with early stage non-small-cell lung cancer (NSCLC) to better understand if its length impacts upstaging. METHODS We retrospectively reviewed our institutional database to identify patients who underwent surgery for clinically staged T1N0M0 NSCLC from January 2015 through September 2022. Tumour upstaging between chest computed tomography (CT) and surgery were analysed as a function of time (&lt;30, 30–59, ≥60 days) for different nodule subtypes. We analysed data across 3 timeframes using Pearson’s chi-squared and analysis of variance tests. RESULTS During the study period, 622 patients underwent surgery for clinically staged T1N0M0 NSCLC. CT-to-surgery interval was &lt;30 days in 228 (36.7%), 30–59 days in 242 (38.9%) and ≥60 days in 152 (24.4%) with no differences in patient or nodule characteristics observed between these groups. T-stage increased in 346 patients (55.6%) between CT imaging and surgery. Among these patients, 126 (36.4%) had ground-glass nodules, 147 (42.5%) had part-solid nodules and 73 (21.1%) had solid nodules. CT-to-surgery interval length was not associated with upstaging of any nodule subtype (full-cohort, P = 0.903; ground-glass, P = 0.880; part-solid, P = 0.858; solid, P = 0.959). CONCLUSIONS This single-centre experience suggests no significant association between tumour upstaging and time from imaging to lung resection in patients with clinical stage IA NSCLC. Further studies are needed to better understand the risk factors for upstaging. Lung cancer is the second most common cancer in both men and women in the USA (excluding non-melanoma skin cancer) and the most lethal neoplasm [1].</description><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFUU1PwzAMjRCIjcGRK8qRS1nSNE16nCY-JiFxGRK3Kk3dKSNNS9IKjV9PxgYcLFv289OzH0LXlNxRUrA5bPUQ5vClgHBxgqZUCpYIlr2dxppQkogiIxN0EcKWEJKzVJyjCZMZEUymUxTWpgVcwfAJ4LBp1ca4DVauxmH0G_A7bAJ23YAV9ia840bpofO4iTH2YTjAuwZra5zRyuJ9D_BqEZdcElplbaLBWmzHCNTKafCX6KxRNsDVMc_Q68P9evmUPL88rpaL56SjIhuSushzzjVJJUS1igsugTU5TwlwWhOd03ix4KxgjCsmdZVVDWhVSK21lCJnM3R74O199zFCGMrWhL0Y5aAbQ5kWLCUpoUxE6M0ROlYt1GXv4yv8rvx91D9XN_Z_U0rKvQfljwfl0QP2DccNeSQ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Barcelos, Rafael R</creator><creator>Sugarbaker, Evert</creator><creator>Kennedy, Kelvin F</creator><creator>McAllister, Miles</creator><creator>Kim, Sangmin</creator><creator>Herrera-Zamora, Julio</creator><creator>Leo, Rachel</creator><creator>Swanson, Scott</creator><creator>Ugalde Figueroa, Paula</creator><general>Oxford University Press</general><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4284-444X</orcidid></search><sort><creationdate>20240201</creationdate><title>Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer</title><author>Barcelos, Rafael R ; Sugarbaker, Evert ; Kennedy, Kelvin F ; McAllister, Miles ; Kim, Sangmin ; Herrera-Zamora, Julio ; Leo, Rachel ; Swanson, Scott ; Ugalde Figueroa, Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o174t-d96655c028e407a5758e3f6520e51d0c610577539335a38cb4bfeca98ccc88763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barcelos, Rafael R</creatorcontrib><creatorcontrib>Sugarbaker, Evert</creatorcontrib><creatorcontrib>Kennedy, Kelvin F</creatorcontrib><creatorcontrib>McAllister, Miles</creatorcontrib><creatorcontrib>Kim, Sangmin</creatorcontrib><creatorcontrib>Herrera-Zamora, Julio</creatorcontrib><creatorcontrib>Leo, Rachel</creatorcontrib><creatorcontrib>Swanson, Scott</creatorcontrib><creatorcontrib>Ugalde Figueroa, Paula</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barcelos, Rafael R</au><au>Sugarbaker, Evert</au><au>Kennedy, Kelvin F</au><au>McAllister, Miles</au><au>Kim, Sangmin</au><au>Herrera-Zamora, Julio</au><au>Leo, Rachel</au><au>Swanson, Scott</au><au>Ugalde Figueroa, Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>65</volume><issue>2</issue><issn>1010-7940</issn><eissn>1873-734X</eissn><abstract>Abstract OBJECTIVES The timing of preoperative imaging in patients with lung cancer is a debated topic, as there are limited data on cancer progression during the interval between clinical staging by imaging and pathological staging after resection. We quantified disease progression during this interval in patients with early stage non-small-cell lung cancer (NSCLC) to better understand if its length impacts upstaging. METHODS We retrospectively reviewed our institutional database to identify patients who underwent surgery for clinically staged T1N0M0 NSCLC from January 2015 through September 2022. Tumour upstaging between chest computed tomography (CT) and surgery were analysed as a function of time (&lt;30, 30–59, ≥60 days) for different nodule subtypes. We analysed data across 3 timeframes using Pearson’s chi-squared and analysis of variance tests. RESULTS During the study period, 622 patients underwent surgery for clinically staged T1N0M0 NSCLC. CT-to-surgery interval was &lt;30 days in 228 (36.7%), 30–59 days in 242 (38.9%) and ≥60 days in 152 (24.4%) with no differences in patient or nodule characteristics observed between these groups. T-stage increased in 346 patients (55.6%) between CT imaging and surgery. Among these patients, 126 (36.4%) had ground-glass nodules, 147 (42.5%) had part-solid nodules and 73 (21.1%) had solid nodules. CT-to-surgery interval length was not associated with upstaging of any nodule subtype (full-cohort, P = 0.903; ground-glass, P = 0.880; part-solid, P = 0.858; solid, P = 0.959). CONCLUSIONS This single-centre experience suggests no significant association between tumour upstaging and time from imaging to lung resection in patients with clinical stage IA NSCLC. Further studies are needed to better understand the risk factors for upstaging. Lung cancer is the second most common cancer in both men and women in the USA (excluding non-melanoma skin cancer) and the most lethal neoplasm [1].</abstract><cop>Germany</cop><pub>Oxford University Press</pub><pmid>38407382</pmid><doi>10.1093/ejcts/ezae057</doi><orcidid>https://orcid.org/0000-0003-4284-444X</orcidid></addata></record>
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title Time between imaging and surgery is not a risk factor for upstaging of clinical stage IA non-small-cell lung cancer
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