Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis

Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate rel...

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Veröffentlicht in:Journal of reproductive immunology 2024-06, Vol.163, p.104215, Article 104215
Hauptverfasser: Bahreiny, Seyed Sobhan, Ahangarpour, Akram, Amraei, Mahdi, Mansouri, Zahra, Pirsadeghi, Ali, Kazemzadeh, Razieh, Javidan, Moslem, Karamali, Negin, Bastani, Mohammad-Navid, Dabbagh, Mohammad Reza
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container_title Journal of reproductive immunology
container_volume 163
creator Bahreiny, Seyed Sobhan
Ahangarpour, Akram
Amraei, Mahdi
Mansouri, Zahra
Pirsadeghi, Ali
Kazemzadeh, Razieh
Javidan, Moslem
Karamali, Negin
Bastani, Mohammad-Navid
Dabbagh, Mohammad Reza
description Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate relationship between PCOS and AIT. A systematic literature search for relevant observational studies was conducted in electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus until March 2023. All Statistical analyses were performed using CMA Software v3.7 in a random-effects network meta-analysis. In addition, sensitivity and meta-regression analyses were conducted to identify sources of Heterogeneity based on related risk factors. Our meta-analysis included eighteen studies with 3657 participants, which revealed significant differences between PCOS patients and control groups. In particular, a considerable association was detected between PCOS and the presence of AIT (OR = 2.38; 95% CI: 1.63–3.49; P< 0.001) and elevated levels of TSH (SMD = 0.24; 95% CI: 0.06–0.42; P= 0.01), anti-TPO (SMD = 0.36; 95% CI: 0.19–0.53; P< 0.001), anti-TG (SMD = 1.24; 95% CI: 0.37–2.10; P< 0.001), and other positive serum antibodies compared to the control groups. The findings from this meta-analysis may contribute to enhanced diagnostic strategies like complete thyroid function tests, more targeted interventions, and improved patient care for individuals presenting with both PCOS and AIT. Additionally, identifying commonalities between these conditions may pave the way for future research directions, guiding the development of novel therapeutic approaches that address the interconnected nature of PCOS and AIT.
doi_str_mv 10.1016/j.jri.2024.104215
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subjects Autoantibodies - blood
Autoantibodies - immunology
Autoimmune thyroid disease
Female
Humans
Hypothyroidism systematic review
Meta-analysis
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diagnosis
Polycystic Ovary Syndrome - epidemiology
Polycystic Ovary Syndrome - immunology
Thyroiditis, Autoimmune - blood
Thyroiditis, Autoimmune - epidemiology
Thyroiditis, Autoimmune - immunology
Thyrotropin - blood
title Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis
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