Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis
Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate rel...
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Veröffentlicht in: | Journal of reproductive immunology 2024-06, Vol.163, p.104215, Article 104215 |
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creator | Bahreiny, Seyed Sobhan Ahangarpour, Akram Amraei, Mahdi Mansouri, Zahra Pirsadeghi, Ali Kazemzadeh, Razieh Javidan, Moslem Karamali, Negin Bastani, Mohammad-Navid Dabbagh, Mohammad Reza |
description | Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate relationship between PCOS and AIT.
A systematic literature search for relevant observational studies was conducted in electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus until March 2023. All Statistical analyses were performed using CMA Software v3.7 in a random-effects network meta-analysis. In addition, sensitivity and meta-regression analyses were conducted to identify sources of Heterogeneity based on related risk factors. Our meta-analysis included eighteen studies with 3657 participants, which revealed significant differences between PCOS patients and control groups. In particular, a considerable association was detected between PCOS and the presence of AIT (OR = 2.38; 95% CI: 1.63–3.49; P< 0.001) and elevated levels of TSH (SMD = 0.24; 95% CI: 0.06–0.42; P= 0.01), anti-TPO (SMD = 0.36; 95% CI: 0.19–0.53; P< 0.001), anti-TG (SMD = 1.24; 95% CI: 0.37–2.10; P< 0.001), and other positive serum antibodies compared to the control groups. The findings from this meta-analysis may contribute to enhanced diagnostic strategies like complete thyroid function tests, more targeted interventions, and improved patient care for individuals presenting with both PCOS and AIT. Additionally, identifying commonalities between these conditions may pave the way for future research directions, guiding the development of novel therapeutic approaches that address the interconnected nature of PCOS and AIT. |
doi_str_mv | 10.1016/j.jri.2024.104215 |
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A systematic literature search for relevant observational studies was conducted in electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus until March 2023. All Statistical analyses were performed using CMA Software v3.7 in a random-effects network meta-analysis. In addition, sensitivity and meta-regression analyses were conducted to identify sources of Heterogeneity based on related risk factors. Our meta-analysis included eighteen studies with 3657 participants, which revealed significant differences between PCOS patients and control groups. In particular, a considerable association was detected between PCOS and the presence of AIT (OR = 2.38; 95% CI: 1.63–3.49; P< 0.001) and elevated levels of TSH (SMD = 0.24; 95% CI: 0.06–0.42; P= 0.01), anti-TPO (SMD = 0.36; 95% CI: 0.19–0.53; P< 0.001), anti-TG (SMD = 1.24; 95% CI: 0.37–2.10; P< 0.001), and other positive serum antibodies compared to the control groups. The findings from this meta-analysis may contribute to enhanced diagnostic strategies like complete thyroid function tests, more targeted interventions, and improved patient care for individuals presenting with both PCOS and AIT. Additionally, identifying commonalities between these conditions may pave the way for future research directions, guiding the development of novel therapeutic approaches that address the interconnected nature of PCOS and AIT.</description><identifier>ISSN: 0165-0378</identifier><identifier>ISSN: 1872-7603</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/j.jri.2024.104215</identifier><identifier>PMID: 38402811</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Autoantibodies - blood ; Autoantibodies - immunology ; Autoimmune thyroid disease ; Female ; Humans ; Hypothyroidism systematic review ; Meta-analysis ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnosis ; Polycystic Ovary Syndrome - epidemiology ; Polycystic Ovary Syndrome - immunology ; Thyroiditis, Autoimmune - blood ; Thyroiditis, Autoimmune - epidemiology ; Thyroiditis, Autoimmune - immunology ; Thyrotropin - blood</subject><ispartof>Journal of reproductive immunology, 2024-06, Vol.163, p.104215, Article 104215</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-f93d011e7fa95f5a68d1d4d3052cc7cccf19668a7c0222b647a0fc5ec76e30683</citedby><cites>FETCH-LOGICAL-c353t-f93d011e7fa95f5a68d1d4d3052cc7cccf19668a7c0222b647a0fc5ec76e30683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jri.2024.104215$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38402811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahreiny, Seyed Sobhan</creatorcontrib><creatorcontrib>Ahangarpour, Akram</creatorcontrib><creatorcontrib>Amraei, Mahdi</creatorcontrib><creatorcontrib>Mansouri, Zahra</creatorcontrib><creatorcontrib>Pirsadeghi, Ali</creatorcontrib><creatorcontrib>Kazemzadeh, Razieh</creatorcontrib><creatorcontrib>Javidan, Moslem</creatorcontrib><creatorcontrib>Karamali, Negin</creatorcontrib><creatorcontrib>Bastani, Mohammad-Navid</creatorcontrib><creatorcontrib>Dabbagh, Mohammad Reza</creatorcontrib><title>Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate relationship between PCOS and AIT.
A systematic literature search for relevant observational studies was conducted in electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus until March 2023. All Statistical analyses were performed using CMA Software v3.7 in a random-effects network meta-analysis. In addition, sensitivity and meta-regression analyses were conducted to identify sources of Heterogeneity based on related risk factors. Our meta-analysis included eighteen studies with 3657 participants, which revealed significant differences between PCOS patients and control groups. In particular, a considerable association was detected between PCOS and the presence of AIT (OR = 2.38; 95% CI: 1.63–3.49; P< 0.001) and elevated levels of TSH (SMD = 0.24; 95% CI: 0.06–0.42; P= 0.01), anti-TPO (SMD = 0.36; 95% CI: 0.19–0.53; P< 0.001), anti-TG (SMD = 1.24; 95% CI: 0.37–2.10; P< 0.001), and other positive serum antibodies compared to the control groups. The findings from this meta-analysis may contribute to enhanced diagnostic strategies like complete thyroid function tests, more targeted interventions, and improved patient care for individuals presenting with both PCOS and AIT. Additionally, identifying commonalities between these conditions may pave the way for future research directions, guiding the development of novel therapeutic approaches that address the interconnected nature of PCOS and AIT.</description><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune thyroid disease</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism systematic review</subject><subject>Meta-analysis</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - diagnosis</subject><subject>Polycystic Ovary Syndrome - epidemiology</subject><subject>Polycystic Ovary Syndrome - immunology</subject><subject>Thyroiditis, Autoimmune - blood</subject><subject>Thyroiditis, Autoimmune - epidemiology</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyrotropin - blood</subject><issn>0165-0378</issn><issn>1872-7603</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi3Uqiy0P4BLlSOXLB47sZNyQogvCakXerbMeALeJvHWTqjy7-tlgWNPo9E87yvNw9gJ8DVwUGeb9Sb6teCiynsloD5gK2i0KLXi8hNbZaYuudTNITtKacM5aN7CF3Yom4qLBmDF5ot5Cn4Y5pGK6XmJwbvC-RSio5gKO7piG_oFlzR5LMKLjUuRltHFMNCP4iFa9ONT0fvxd8rxGOan53xPEw12F4j04unva81Aky3taPsl-fSVfe5sn-jb2zxmv66vHi5vy_ufN3eXF_clylpOZddKxwFId7atu9qqxoGrnOS1QNSI2EGrVGM1ciHEo6q05R3WhFqR5KqRx-x037uN4c9MaTKDT0h9b0cKczKilYJDU4HKKOxRjCGlSJ3ZRj_kfw1ws7NtNibbNjvbZm87Z76_1c-PA7mPxLveDJzvAcpPZhXRJPQ0IjkfCSfjgv9P_T9EvJKQ</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Bahreiny, Seyed Sobhan</creator><creator>Ahangarpour, Akram</creator><creator>Amraei, Mahdi</creator><creator>Mansouri, Zahra</creator><creator>Pirsadeghi, Ali</creator><creator>Kazemzadeh, Razieh</creator><creator>Javidan, Moslem</creator><creator>Karamali, Negin</creator><creator>Bastani, Mohammad-Navid</creator><creator>Dabbagh, Mohammad Reza</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202406</creationdate><title>Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis</title><author>Bahreiny, Seyed Sobhan ; Ahangarpour, Akram ; Amraei, Mahdi ; Mansouri, Zahra ; Pirsadeghi, Ali ; Kazemzadeh, Razieh ; Javidan, Moslem ; Karamali, Negin ; Bastani, Mohammad-Navid ; Dabbagh, Mohammad Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-f93d011e7fa95f5a68d1d4d3052cc7cccf19668a7c0222b647a0fc5ec76e30683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmune thyroid disease</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism systematic review</topic><topic>Meta-analysis</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - diagnosis</topic><topic>Polycystic Ovary Syndrome - epidemiology</topic><topic>Polycystic Ovary Syndrome - immunology</topic><topic>Thyroiditis, Autoimmune - blood</topic><topic>Thyroiditis, Autoimmune - epidemiology</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyrotropin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahreiny, Seyed Sobhan</creatorcontrib><creatorcontrib>Ahangarpour, Akram</creatorcontrib><creatorcontrib>Amraei, Mahdi</creatorcontrib><creatorcontrib>Mansouri, Zahra</creatorcontrib><creatorcontrib>Pirsadeghi, Ali</creatorcontrib><creatorcontrib>Kazemzadeh, Razieh</creatorcontrib><creatorcontrib>Javidan, Moslem</creatorcontrib><creatorcontrib>Karamali, Negin</creatorcontrib><creatorcontrib>Bastani, Mohammad-Navid</creatorcontrib><creatorcontrib>Dabbagh, Mohammad Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahreiny, Seyed Sobhan</au><au>Ahangarpour, Akram</au><au>Amraei, Mahdi</au><au>Mansouri, Zahra</au><au>Pirsadeghi, Ali</au><au>Kazemzadeh, Razieh</au><au>Javidan, Moslem</au><au>Karamali, Negin</au><au>Bastani, Mohammad-Navid</au><au>Dabbagh, Mohammad Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2024-06</date><risdate>2024</risdate><volume>163</volume><spage>104215</spage><pages>104215-</pages><artnum>104215</artnum><issn>0165-0378</issn><issn>1872-7603</issn><eissn>1872-7603</eissn><abstract>Polycystic Ovary Syndrome (PCOS) and Autoimmune Thyroiditis (AIT) are two prevalent endocrine disorders affecting women, often coexisting within the same patient population. This meta-analysis aims to systematically assess and synthesize the existing body of literature to elucidate the intricate relationship between PCOS and AIT.
A systematic literature search for relevant observational studies was conducted in electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus until March 2023. All Statistical analyses were performed using CMA Software v3.7 in a random-effects network meta-analysis. In addition, sensitivity and meta-regression analyses were conducted to identify sources of Heterogeneity based on related risk factors. Our meta-analysis included eighteen studies with 3657 participants, which revealed significant differences between PCOS patients and control groups. In particular, a considerable association was detected between PCOS and the presence of AIT (OR = 2.38; 95% CI: 1.63–3.49; P< 0.001) and elevated levels of TSH (SMD = 0.24; 95% CI: 0.06–0.42; P= 0.01), anti-TPO (SMD = 0.36; 95% CI: 0.19–0.53; P< 0.001), anti-TG (SMD = 1.24; 95% CI: 0.37–2.10; P< 0.001), and other positive serum antibodies compared to the control groups. The findings from this meta-analysis may contribute to enhanced diagnostic strategies like complete thyroid function tests, more targeted interventions, and improved patient care for individuals presenting with both PCOS and AIT. Additionally, identifying commonalities between these conditions may pave the way for future research directions, guiding the development of novel therapeutic approaches that address the interconnected nature of PCOS and AIT.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>38402811</pmid><doi>10.1016/j.jri.2024.104215</doi></addata></record> |
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subjects | Autoantibodies - blood Autoantibodies - immunology Autoimmune thyroid disease Female Humans Hypothyroidism systematic review Meta-analysis Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - epidemiology Polycystic Ovary Syndrome - immunology Thyroiditis, Autoimmune - blood Thyroiditis, Autoimmune - epidemiology Thyroiditis, Autoimmune - immunology Thyrotropin - blood |
title | Autoimmune thyroid disorders and polycystic ovary syndrome: Tracing links through systematic review and meta-analysis |
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