RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

Ischemic stroke is a major cause of death and disability in adults. Hypothermic treatment is successful in treating neonatal cerebral ischemia, but its application is restricted in adult patients due to complex management strategies and severe adverse effects. Two homologous RNA-binding proteins, RB...

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Veröffentlicht in:	Molecular neurobiology 2024-10, Vol.61 (10), p.7384-7402
Hauptverfasser:	Zhao, Junyi, Liu, Siyu, Li, Kunyu, Yang, Yulu, Zhao, Yue, Zhu, Xinzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Brain Ischemia - metabolism Brain Ischemia - pathology Cell Biology Cell culture Cell Survival - drug effects Humans Hypothermia Inflammation Inflammation - metabolism Inflammation - pathology Ischemia Ischemic Stroke - metabolism Ischemic Stroke - pathology Male Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Neonates Neurobiology Neurology Neurons - metabolism Neurons - pathology Neuroprotection Neuroprotection - drug effects Neuroprotective Agents - pharmacology Neurosciences Original Article Proteins RNA-binding protein RNA-Binding Proteins - metabolism Stroke Therapeutic targets
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