Iodine-Mediated δ‑Amination of sp3 C–H Bonds

Iodine-Mediated δ‑Amination of sp3 C–H Bonds

We present a direct δ-amination reaction of sp3 C–H bonds, employing molecular iodine (I2) as the sole oxidant under transition-metal-free conditions. This remote C–H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic der...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2024-03, Vol.89 (5), p.3481-3490
Hauptverfasser: Ye, Wenjun, Xiong, Hanyu, Wang, Manman, Chang, Junbiao, Yu, Wenquan
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We present a direct δ-amination reaction of sp3 C–H bonds, employing molecular iodine (I2) as the sole oxidant under transition-metal-free conditions. This remote C–H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic derivatives from readily accessible substrates.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02901