Biomanufacture of L-homoserine lactone building block: A strategy for preparing γ-substituted L-amino acids by modular reaction

A strain high-performance of esterase producing bacteria was screened from soil, which could selectively hydrolyze D-homoserine lactone from its racemate to achieve the resolution of L- homoserine lactone with more than 99% e.e. in 48% yield. L-homoserine lactone building block was then converted to...

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Veröffentlicht in:	Enzyme and microbial technology 2024-05, Vol.176, p.110411-110411, Article 110411
Hauptverfasser:	Wang, Yuguang, Wu, Mengjing, Zheng, Huifang, Wu, Dongmei, Yao, Panpan, Li, Wenjing, Jin, Kexin, Yu, Xinjun
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives Amino Acids Biocatalysis Biomanufacturing Building block L-homoserine lactone Lactones Modular reaction Serine
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