Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments
The tumor immune microenvironment of thyroid cancer is the heterogeneous histological space in which tumor cells coexist with host cells. Published data from this review were identified by search and selection database of Pubmed, Elsevier, and Science Direct. Searching was made in two steps using di...
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| Veröffentlicht in: | Head & neck 2024-06, Vol.46 (6), p.1486-1499 |
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| creator | Febrero, Beatriz Ruiz‐Manzanera, Juan José Ros‐Madrid, Inmaculada Hernández, Antonio Miguel Orenes‐Piñero, Esteban Rodríguez, José Manuel |
| description | The tumor immune microenvironment of thyroid cancer is the heterogeneous histological space in which tumor cells coexist with host cells. Published data from this review were identified by search and selection database of Pubmed, Elsevier, and Science Direct. Searching was made in two steps using different keywords. In thyroid pathology, the inflammatory response is very important, and might have a key role finding new diagnostic and therapeutic methods, particularly in thyroid cancer. Different immune cells may be more or less present in different types of thyroid cancer and may even have different functions, hence the importance of knowing their presence in different thyroid tumor pathologies. Cancer‐related inflammation could be a useful target for new diagnostic and therapeutic strategies by analyzing peritumoral and intratumoral immune cells in different types of thyroid tumors. Moreover, novel strategies for thyroid cancer treatments, such as monoclonal antibodies targeting checkpoint inhibitors, are emerging as promising alternatives. |
| doi_str_mv | 10.1002/hed.27695 |
| format | Article |
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| subjects | anaplastic thyroid carcinoma Cancer therapies Humans immune cells Immune checkpoint inhibitors Immune Checkpoint Inhibitors - therapeutic use immune checkpoints Inflammation medullary thyroid carcinoma Monoclonal antibodies papillary thyroid carcinoma Thyroid cancer Thyroid Neoplasms - immunology Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Tumor cells Tumor microenvironment Tumor Microenvironment - immunology Tumors |
| title | Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments |
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