Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis
We aimed to examine the association between baseline platelet count (PLT) and the prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH). Data from 292 patients with pretreatment platelet counts were retrospectively analysed from January 2016 to December 2020. We categorized platelet...
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| Veröffentlicht in: | Annals of hematology 2024-04, Vol.103 (4), p.1159-1166 |
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| creator | Cheng, Wanying Xu, Ji Shu, Yongqian Qiu, Hongxia Yin, Guangli |
| description | We aimed to examine the association between baseline platelet count (PLT) and the prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH). Data from 292 patients with pretreatment platelet counts were retrospectively analysed from January 2016 to December 2020. We categorized platelet count into quartiles. Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were used to evaluate the relationship between platelet count and mortality. During a median follow-up of 53 (interquartile ranges, 17-223) days, a total of 208 deaths occurred. After adjusting for multiple variables, a non-linear and inverse relationship was observed between platelet count and mortality in sHLH patient (
P
for nonlinearity=0.002). For non- lymphoma-associated haemophagocytic lymphohistiocytosis (non-LHLH), a similar curve was also observed (
P
for nonlinearity =0.028). Decreased PLT (PLT Q4) was associated with an increased risk of mortality (adjusted hazard ratio: 1.97; 95% confidence interval: 1.28-3.04;
P
trend
=0.005). Similar results were observed in the LHLH subgroup (adjusted hazard ratio: 1.84; 95% confidence interval: 1.05-3.24;
P
trend
=0.024) but not in the non-LHLH subgroup (
P
trend
=0.266). Baseline platelet count demonstrated a nonlinear and inverse association with an increased risk of mortality among adult sHLH patients. This method is used to identify sHLH patients with inferior overall survival due to its low cost and universal availability.
Graphical Abstract |
| doi_str_mv | 10.1007/s00277-024-05663-6 |
| format | Article |
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P
for nonlinearity=0.002). For non- lymphoma-associated haemophagocytic lymphohistiocytosis (non-LHLH), a similar curve was also observed (
P
for nonlinearity =0.028). Decreased PLT (PLT Q4) was associated with an increased risk of mortality (adjusted hazard ratio: 1.97; 95% confidence interval: 1.28-3.04;
P
trend
=0.005). Similar results were observed in the LHLH subgroup (adjusted hazard ratio: 1.84; 95% confidence interval: 1.05-3.24;
P
trend
=0.024) but not in the non-LHLH subgroup (
P
trend
=0.266). Baseline platelet count demonstrated a nonlinear and inverse association with an increased risk of mortality among adult sHLH patients. This method is used to identify sHLH patients with inferior overall survival due to its low cost and universal availability.
Graphical Abstract</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-024-05663-6</identifier><identifier>PMID: 38378930</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Hematology ; Humans ; Lymphohistiocytosis, Hemophagocytic - etiology ; Lymphoma - complications ; Medical prognosis ; Medicine ; Medicine & Public Health ; Mortality ; Oncology ; Original Article ; Platelet Count ; Prognosis ; Retrospective Studies</subject><ispartof>Annals of hematology, 2024-04, Vol.103 (4), p.1159-1166</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-6a682a820c15dce4d91dfcb2334aa34624c2135211ccf58a5b2b5d172fc7bf503</cites><orcidid>0000-0003-0400-7165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-024-05663-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-024-05663-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38378930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Wanying</creatorcontrib><creatorcontrib>Xu, Ji</creatorcontrib><creatorcontrib>Shu, Yongqian</creatorcontrib><creatorcontrib>Qiu, Hongxia</creatorcontrib><creatorcontrib>Yin, Guangli</creatorcontrib><title>Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>We aimed to examine the association between baseline platelet count (PLT) and the prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH). Data from 292 patients with pretreatment platelet counts were retrospectively analysed from January 2016 to December 2020. We categorized platelet count into quartiles. Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were used to evaluate the relationship between platelet count and mortality. During a median follow-up of 53 (interquartile ranges, 17-223) days, a total of 208 deaths occurred. After adjusting for multiple variables, a non-linear and inverse relationship was observed between platelet count and mortality in sHLH patient (
P
for nonlinearity=0.002). For non- lymphoma-associated haemophagocytic lymphohistiocytosis (non-LHLH), a similar curve was also observed (
P
for nonlinearity =0.028). Decreased PLT (PLT Q4) was associated with an increased risk of mortality (adjusted hazard ratio: 1.97; 95% confidence interval: 1.28-3.04;
P
trend
=0.005). Similar results were observed in the LHLH subgroup (adjusted hazard ratio: 1.84; 95% confidence interval: 1.05-3.24;
P
trend
=0.024) but not in the non-LHLH subgroup (
P
trend
=0.266). Baseline platelet count demonstrated a nonlinear and inverse association with an increased risk of mortality among adult sHLH patients. This method is used to identify sHLH patients with inferior overall survival due to its low cost and universal availability.
Graphical Abstract</description><subject>Adult</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymphohistiocytosis, Hemophagocytic - etiology</subject><subject>Lymphoma - complications</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUGP1SAUhYnROG-e_gEXhsSNmypcCm2Xk8mok0ziRteEAp0yaUvl0jFv50-XsaMmLmRD4H7nXLiHkFecveOMNe-RMWiaikFdMamUqNQTcuC1gHJs66fkwDrRVbKsM3KOeMcYh7aG5-RMtKJpO8EO5McFYrTB5BAXGgdqqPM2eYPe0XUy2U8-Uxu3JdPvIY90jTFR3NJ9uDcTDQtdi9QvGfeycduUKXobF2fSiY5-jutobqM95WDpdJrXMY4BS7tyEzHgC_JsMBP6l4_7kXz9cPXl8lN18_nj9eXFTWUFqFwpo1owLTDLpbO-dh13g-1BiNoYUSuoLXAhgXNrB9ka2UMvHW9gsE0_SCaO5O3uu6b4bfOY9RzQ-mkyi48bauigk2UuZX5H8uYf9C5uaSmvK5RUnZSCqULBTtkUEZMf9JrCXD6tOdMP-eg9H13y0b_y0Q-i14_WWz9790fyO5ACiB3AUlpuffrb-z-2PwF7-p4m</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Cheng, Wanying</creator><creator>Xu, Ji</creator><creator>Shu, Yongqian</creator><creator>Qiu, Hongxia</creator><creator>Yin, Guangli</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0400-7165</orcidid></search><sort><creationdate>20240401</creationdate><title>Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis</title><author>Cheng, Wanying ; Xu, Ji ; Shu, Yongqian ; Qiu, Hongxia ; Yin, Guangli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-6a682a820c15dce4d91dfcb2334aa34624c2135211ccf58a5b2b5d172fc7bf503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Hematology</topic><topic>Humans</topic><topic>Lymphohistiocytosis, Hemophagocytic - etiology</topic><topic>Lymphoma - complications</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Platelet Count</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Wanying</creatorcontrib><creatorcontrib>Xu, Ji</creatorcontrib><creatorcontrib>Shu, Yongqian</creatorcontrib><creatorcontrib>Qiu, Hongxia</creatorcontrib><creatorcontrib>Yin, Guangli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Wanying</au><au>Xu, Ji</au><au>Shu, Yongqian</au><au>Qiu, Hongxia</au><au>Yin, Guangli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>103</volume><issue>4</issue><spage>1159</spage><epage>1166</epage><pages>1159-1166</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>We aimed to examine the association between baseline platelet count (PLT) and the prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH). Data from 292 patients with pretreatment platelet counts were retrospectively analysed from January 2016 to December 2020. We categorized platelet count into quartiles. Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were used to evaluate the relationship between platelet count and mortality. During a median follow-up of 53 (interquartile ranges, 17-223) days, a total of 208 deaths occurred. After adjusting for multiple variables, a non-linear and inverse relationship was observed between platelet count and mortality in sHLH patient (
P
for nonlinearity=0.002). For non- lymphoma-associated haemophagocytic lymphohistiocytosis (non-LHLH), a similar curve was also observed (
P
for nonlinearity =0.028). Decreased PLT (PLT Q4) was associated with an increased risk of mortality (adjusted hazard ratio: 1.97; 95% confidence interval: 1.28-3.04;
P
trend
=0.005). Similar results were observed in the LHLH subgroup (adjusted hazard ratio: 1.84; 95% confidence interval: 1.05-3.24;
P
trend
=0.024) but not in the non-LHLH subgroup (
P
trend
=0.266). Baseline platelet count demonstrated a nonlinear and inverse association with an increased risk of mortality among adult sHLH patients. This method is used to identify sHLH patients with inferior overall survival due to its low cost and universal availability.
Graphical Abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38378930</pmid><doi>10.1007/s00277-024-05663-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0400-7165</orcidid></addata></record> |
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| subjects | Adult Hematology Humans Lymphohistiocytosis, Hemophagocytic - etiology Lymphoma - complications Medical prognosis Medicine Medicine & Public Health Mortality Oncology Original Article Platelet Count Prognosis Retrospective Studies |
| title | Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis |
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