A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission
Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific salivary components facilitating viral transmission and their mechanisms of action remain largely unknown. Here, we show that a female mos...
Gespeichert in:
| Veröffentlicht in: | The EMBO journal 2024-05, Vol.43 (9), p.1690-1721 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1721 |
|---|---|
| container_issue | 9 |
| container_start_page | 1690 |
| container_title | The EMBO journal |
| container_volume | 43 |
| creator | Wang, Zhaoyang Nie, Kaixiao Liang, Yan Niu, Jichen Yu, Xi Zhang, Oujia Liu, Long Shi, Xiaolu Wang, Yibaina Feng, Xuechun Zhu, Yibin Wang, Penghua Cheng, Gong |
| description | Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific salivary components facilitating viral transmission and their mechanisms of action remain largely unknown. Here, we show that a female mosquito salivary gland-specific protein, here named
A. aegypti
Neutrophil Recruitment Protein (
Aa
NRP), facilitates the transmission of Zika and dengue viruses.
Aa
NRP promotes a rapid influx of neutrophils, followed by virus-susceptible myeloid cells toward mosquito bite sites, which facilitates establishment of local infection and systemic dissemination. Mechanistically,
Aa
NRP engages TLR1 and TLR4 of skin-resident macrophages and activates MyD88-dependent NF-κB signaling to induce the expression of neutrophil chemoattractants. Inhibition of MyD88-NF-κB signaling with the dietary phytochemical resveratrol reduces
Aa
NRP-mediated enhancement of flavivirus transmission by mosquitoes. These findings exemplify how salivary components can aid viral transmission, and suggest a potential prophylactic target.
Synopsis
Mosquito saliva contains factors that promote flavivirus infection in the animal host. This study reveals that the mosquito salivary protein
Aa
NRP mediates cutaneous recruitment of flavivirus-susceptible myeloid cells to mosquito bite sites, thus aiding flavivirus transmission.
Aa
NRP is a female-mosquito-specific salivary protein.
Aa
NRP stimulates skin-resident macrophages via TLR1/4-MyD88-NF-κB signaling to release chemoattractants for neutrophils.
The
Aa
NRP-induced influx of myeloid cells promotes flaviviral cutaneous infection.
Dietary supplementation with resveratrol suppresses
Aa
NRP-promoted flavivirus transmission by mosquitoes.
Aa
NRP is a female-specific mosquito salivary protein that promotes Zika and dengue virus infection by stimulating skin macrophage-dependent neutrophil recruitment. |
| doi_str_mv | 10.1038/s44318-024-00056-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2929538151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2929538151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-6860483b7d41ff5bf43a22ef1bcc9ecf60b7ec5fb91bd9da64666cb15e3519583</originalsourceid><addsrcrecordid>eNp9kE9PwyAYh4nRuDn9Ah4MRy9VKIXS47L4L1niRa8SSsGw0LJB22zfXuam8eSJN-F5f_m9DwDXGN1hRPh9LAqCeYbyIkMIUZZtT8AUFwxlOSrp6Z95Ai5iXO0hXuJzMCGclJxXeAo-5rD1cTPY3sMonR1l2MF18L22XdYEO-oO2s64YQu9ge1OO28bqLRzERqprLO97HWanRztaMMQYR9kF1sbo_XdJTgz0kV9dXxn4P3x4W3xnC1fn14W82WmSIX7jHGGCk7qsimwMbQ2BZF5rg2ulaq0MgzVpVbU1BWum6qRrGCMqRpTTSiuKCczcHvITdU3g469SAX2LWWn_RBFXuUVJRxTnND8gKrgYwzaiHWwbTpbYCT2XsXBq0hexbdXsU1LN8f8oW5187vyIzIB5ADE9NV96iBWfghduvm_2C9T5Yaa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2929538151</pqid></control><display><type>article</type><title>A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Wang, Zhaoyang ; Nie, Kaixiao ; Liang, Yan ; Niu, Jichen ; Yu, Xi ; Zhang, Oujia ; Liu, Long ; Shi, Xiaolu ; Wang, Yibaina ; Feng, Xuechun ; Zhu, Yibin ; Wang, Penghua ; Cheng, Gong</creator><creatorcontrib>Wang, Zhaoyang ; Nie, Kaixiao ; Liang, Yan ; Niu, Jichen ; Yu, Xi ; Zhang, Oujia ; Liu, Long ; Shi, Xiaolu ; Wang, Yibaina ; Feng, Xuechun ; Zhu, Yibin ; Wang, Penghua ; Cheng, Gong</creatorcontrib><description>Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific salivary components facilitating viral transmission and their mechanisms of action remain largely unknown. Here, we show that a female mosquito salivary gland-specific protein, here named
A. aegypti
Neutrophil Recruitment Protein (
Aa
NRP), facilitates the transmission of Zika and dengue viruses.
Aa
NRP promotes a rapid influx of neutrophils, followed by virus-susceptible myeloid cells toward mosquito bite sites, which facilitates establishment of local infection and systemic dissemination. Mechanistically,
Aa
NRP engages TLR1 and TLR4 of skin-resident macrophages and activates MyD88-dependent NF-κB signaling to induce the expression of neutrophil chemoattractants. Inhibition of MyD88-NF-κB signaling with the dietary phytochemical resveratrol reduces
Aa
NRP-mediated enhancement of flavivirus transmission by mosquitoes. These findings exemplify how salivary components can aid viral transmission, and suggest a potential prophylactic target.
Synopsis
Mosquito saliva contains factors that promote flavivirus infection in the animal host. This study reveals that the mosquito salivary protein
Aa
NRP mediates cutaneous recruitment of flavivirus-susceptible myeloid cells to mosquito bite sites, thus aiding flavivirus transmission.
Aa
NRP is a female-mosquito-specific salivary protein.
Aa
NRP stimulates skin-resident macrophages via TLR1/4-MyD88-NF-κB signaling to release chemoattractants for neutrophils.
The
Aa
NRP-induced influx of myeloid cells promotes flaviviral cutaneous infection.
Dietary supplementation with resveratrol suppresses
Aa
NRP-promoted flavivirus transmission by mosquitoes.
Aa
NRP is a female-specific mosquito salivary protein that promotes Zika and dengue virus infection by stimulating skin macrophage-dependent neutrophil recruitment.</description><identifier>ISSN: 1460-2075</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1038/s44318-024-00056-x</identifier><identifier>PMID: 38378891</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aedes - metabolism ; Aedes - virology ; Animals ; Biomedical and Life Sciences ; Dengue - metabolism ; Dengue - transmission ; Dengue - virology ; Dengue Virus - physiology ; EMBO19 ; EMBO23 ; Female ; Insect Proteins - metabolism ; Life Sciences ; Mice ; Mosquito Vectors - virology ; Myeloid Cells - metabolism ; Myeloid Cells - virology ; Myeloid Differentiation Factor 88 - genetics ; Myeloid Differentiation Factor 88 - metabolism ; NF-kappa B - metabolism ; Salivary Proteins and Peptides - metabolism ; Signal Transduction ; Zika Virus - physiology ; Zika Virus Infection - metabolism ; Zika Virus Infection - transmission ; Zika Virus Infection - virology</subject><ispartof>The EMBO journal, 2024-05, Vol.43 (9), p.1690-1721</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-6860483b7d41ff5bf43a22ef1bcc9ecf60b7ec5fb91bd9da64666cb15e3519583</citedby><cites>FETCH-LOGICAL-c391t-6860483b7d41ff5bf43a22ef1bcc9ecf60b7ec5fb91bd9da64666cb15e3519583</cites><orcidid>0000-0002-7332-1871 ; 0000-0001-7447-5488 ; 0000-0003-2773-2474 ; 0000-0002-1265-7603</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s44318-024-00056-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://doi.org/10.1038/s44318-024-00056-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,27924,27925,41120,42189,51576</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38378891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhaoyang</creatorcontrib><creatorcontrib>Nie, Kaixiao</creatorcontrib><creatorcontrib>Liang, Yan</creatorcontrib><creatorcontrib>Niu, Jichen</creatorcontrib><creatorcontrib>Yu, Xi</creatorcontrib><creatorcontrib>Zhang, Oujia</creatorcontrib><creatorcontrib>Liu, Long</creatorcontrib><creatorcontrib>Shi, Xiaolu</creatorcontrib><creatorcontrib>Wang, Yibaina</creatorcontrib><creatorcontrib>Feng, Xuechun</creatorcontrib><creatorcontrib>Zhu, Yibin</creatorcontrib><creatorcontrib>Wang, Penghua</creatorcontrib><creatorcontrib>Cheng, Gong</creatorcontrib><title>A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><addtitle>EMBO J</addtitle><description>Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific salivary components facilitating viral transmission and their mechanisms of action remain largely unknown. Here, we show that a female mosquito salivary gland-specific protein, here named
A. aegypti
Neutrophil Recruitment Protein (
Aa
NRP), facilitates the transmission of Zika and dengue viruses.
Aa
NRP promotes a rapid influx of neutrophils, followed by virus-susceptible myeloid cells toward mosquito bite sites, which facilitates establishment of local infection and systemic dissemination. Mechanistically,
Aa
NRP engages TLR1 and TLR4 of skin-resident macrophages and activates MyD88-dependent NF-κB signaling to induce the expression of neutrophil chemoattractants. Inhibition of MyD88-NF-κB signaling with the dietary phytochemical resveratrol reduces
Aa
NRP-mediated enhancement of flavivirus transmission by mosquitoes. These findings exemplify how salivary components can aid viral transmission, and suggest a potential prophylactic target.
Synopsis
Mosquito saliva contains factors that promote flavivirus infection in the animal host. This study reveals that the mosquito salivary protein
Aa
NRP mediates cutaneous recruitment of flavivirus-susceptible myeloid cells to mosquito bite sites, thus aiding flavivirus transmission.
Aa
NRP is a female-mosquito-specific salivary protein.
Aa
NRP stimulates skin-resident macrophages via TLR1/4-MyD88-NF-κB signaling to release chemoattractants for neutrophils.
The
Aa
NRP-induced influx of myeloid cells promotes flaviviral cutaneous infection.
Dietary supplementation with resveratrol suppresses
Aa
NRP-promoted flavivirus transmission by mosquitoes.
Aa
NRP is a female-specific mosquito salivary protein that promotes Zika and dengue virus infection by stimulating skin macrophage-dependent neutrophil recruitment.</description><subject>Aedes - metabolism</subject><subject>Aedes - virology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Dengue - metabolism</subject><subject>Dengue - transmission</subject><subject>Dengue - virology</subject><subject>Dengue Virus - physiology</subject><subject>EMBO19</subject><subject>EMBO23</subject><subject>Female</subject><subject>Insect Proteins - metabolism</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mosquito Vectors - virology</subject><subject>Myeloid Cells - metabolism</subject><subject>Myeloid Cells - virology</subject><subject>Myeloid Differentiation Factor 88 - genetics</subject><subject>Myeloid Differentiation Factor 88 - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>Salivary Proteins and Peptides - metabolism</subject><subject>Signal Transduction</subject><subject>Zika Virus - physiology</subject><subject>Zika Virus Infection - metabolism</subject><subject>Zika Virus Infection - transmission</subject><subject>Zika Virus Infection - virology</subject><issn>1460-2075</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kE9PwyAYh4nRuDn9Ah4MRy9VKIXS47L4L1niRa8SSsGw0LJB22zfXuam8eSJN-F5f_m9DwDXGN1hRPh9LAqCeYbyIkMIUZZtT8AUFwxlOSrp6Z95Ai5iXO0hXuJzMCGclJxXeAo-5rD1cTPY3sMonR1l2MF18L22XdYEO-oO2s64YQu9ge1OO28bqLRzERqprLO97HWanRztaMMQYR9kF1sbo_XdJTgz0kV9dXxn4P3x4W3xnC1fn14W82WmSIX7jHGGCk7qsimwMbQ2BZF5rg2ulaq0MgzVpVbU1BWum6qRrGCMqRpTTSiuKCczcHvITdU3g469SAX2LWWn_RBFXuUVJRxTnND8gKrgYwzaiHWwbTpbYCT2XsXBq0hexbdXsU1LN8f8oW5187vyIzIB5ADE9NV96iBWfghduvm_2C9T5Yaa</recordid><startdate>20240502</startdate><enddate>20240502</enddate><creator>Wang, Zhaoyang</creator><creator>Nie, Kaixiao</creator><creator>Liang, Yan</creator><creator>Niu, Jichen</creator><creator>Yu, Xi</creator><creator>Zhang, Oujia</creator><creator>Liu, Long</creator><creator>Shi, Xiaolu</creator><creator>Wang, Yibaina</creator><creator>Feng, Xuechun</creator><creator>Zhu, Yibin</creator><creator>Wang, Penghua</creator><creator>Cheng, Gong</creator><general>Nature Publishing Group UK</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7332-1871</orcidid><orcidid>https://orcid.org/0000-0001-7447-5488</orcidid><orcidid>https://orcid.org/0000-0003-2773-2474</orcidid><orcidid>https://orcid.org/0000-0002-1265-7603</orcidid></search><sort><creationdate>20240502</creationdate><title>A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission</title><author>Wang, Zhaoyang ; Nie, Kaixiao ; Liang, Yan ; Niu, Jichen ; Yu, Xi ; Zhang, Oujia ; Liu, Long ; Shi, Xiaolu ; Wang, Yibaina ; Feng, Xuechun ; Zhu, Yibin ; Wang, Penghua ; Cheng, Gong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-6860483b7d41ff5bf43a22ef1bcc9ecf60b7ec5fb91bd9da64666cb15e3519583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aedes - metabolism</topic><topic>Aedes - virology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Dengue - metabolism</topic><topic>Dengue - transmission</topic><topic>Dengue - virology</topic><topic>Dengue Virus - physiology</topic><topic>EMBO19</topic><topic>EMBO23</topic><topic>Female</topic><topic>Insect Proteins - metabolism</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mosquito Vectors - virology</topic><topic>Myeloid Cells - metabolism</topic><topic>Myeloid Cells - virology</topic><topic>Myeloid Differentiation Factor 88 - genetics</topic><topic>Myeloid Differentiation Factor 88 - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>Salivary Proteins and Peptides - metabolism</topic><topic>Signal Transduction</topic><topic>Zika Virus - physiology</topic><topic>Zika Virus Infection - metabolism</topic><topic>Zika Virus Infection - transmission</topic><topic>Zika Virus Infection - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhaoyang</creatorcontrib><creatorcontrib>Nie, Kaixiao</creatorcontrib><creatorcontrib>Liang, Yan</creatorcontrib><creatorcontrib>Niu, Jichen</creatorcontrib><creatorcontrib>Yu, Xi</creatorcontrib><creatorcontrib>Zhang, Oujia</creatorcontrib><creatorcontrib>Liu, Long</creatorcontrib><creatorcontrib>Shi, Xiaolu</creatorcontrib><creatorcontrib>Wang, Yibaina</creatorcontrib><creatorcontrib>Feng, Xuechun</creatorcontrib><creatorcontrib>Zhu, Yibin</creatorcontrib><creatorcontrib>Wang, Penghua</creatorcontrib><creatorcontrib>Cheng, Gong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhaoyang</au><au>Nie, Kaixiao</au><au>Liang, Yan</au><au>Niu, Jichen</au><au>Yu, Xi</au><au>Zhang, Oujia</au><au>Liu, Long</au><au>Shi, Xiaolu</au><au>Wang, Yibaina</au><au>Feng, Xuechun</au><au>Zhu, Yibin</au><au>Wang, Penghua</au><au>Cheng, Gong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>2024-05-02</date><risdate>2024</risdate><volume>43</volume><issue>9</issue><spage>1690</spage><epage>1721</epage><pages>1690-1721</pages><issn>1460-2075</issn><eissn>1460-2075</eissn><abstract>Mosquitoes transmit many disease-relevant flaviviruses. Efficient viral transmission to mammalian hosts requires mosquito salivary factors. However, the specific salivary components facilitating viral transmission and their mechanisms of action remain largely unknown. Here, we show that a female mosquito salivary gland-specific protein, here named
A. aegypti
Neutrophil Recruitment Protein (
Aa
NRP), facilitates the transmission of Zika and dengue viruses.
Aa
NRP promotes a rapid influx of neutrophils, followed by virus-susceptible myeloid cells toward mosquito bite sites, which facilitates establishment of local infection and systemic dissemination. Mechanistically,
Aa
NRP engages TLR1 and TLR4 of skin-resident macrophages and activates MyD88-dependent NF-κB signaling to induce the expression of neutrophil chemoattractants. Inhibition of MyD88-NF-κB signaling with the dietary phytochemical resveratrol reduces
Aa
NRP-mediated enhancement of flavivirus transmission by mosquitoes. These findings exemplify how salivary components can aid viral transmission, and suggest a potential prophylactic target.
Synopsis
Mosquito saliva contains factors that promote flavivirus infection in the animal host. This study reveals that the mosquito salivary protein
Aa
NRP mediates cutaneous recruitment of flavivirus-susceptible myeloid cells to mosquito bite sites, thus aiding flavivirus transmission.
Aa
NRP is a female-mosquito-specific salivary protein.
Aa
NRP stimulates skin-resident macrophages via TLR1/4-MyD88-NF-κB signaling to release chemoattractants for neutrophils.
The
Aa
NRP-induced influx of myeloid cells promotes flaviviral cutaneous infection.
Dietary supplementation with resveratrol suppresses
Aa
NRP-promoted flavivirus transmission by mosquitoes.
Aa
NRP is a female-specific mosquito salivary protein that promotes Zika and dengue virus infection by stimulating skin macrophage-dependent neutrophil recruitment.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38378891</pmid><doi>10.1038/s44318-024-00056-x</doi><tpages>32</tpages><orcidid>https://orcid.org/0000-0002-7332-1871</orcidid><orcidid>https://orcid.org/0000-0001-7447-5488</orcidid><orcidid>https://orcid.org/0000-0003-2773-2474</orcidid><orcidid>https://orcid.org/0000-0002-1265-7603</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1460-2075 |
| ispartof | The EMBO journal, 2024-05, Vol.43 (9), p.1690-1721 |
| issn | 1460-2075 1460-2075 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2929538151 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Aedes - metabolism Aedes - virology Animals Biomedical and Life Sciences Dengue - metabolism Dengue - transmission Dengue - virology Dengue Virus - physiology EMBO19 EMBO23 Female Insect Proteins - metabolism Life Sciences Mice Mosquito Vectors - virology Myeloid Cells - metabolism Myeloid Cells - virology Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism Salivary Proteins and Peptides - metabolism Signal Transduction Zika Virus - physiology Zika Virus Infection - metabolism Zika Virus Infection - transmission Zika Virus Infection - virology |
| title | A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T22%3A47%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20mosquito%20salivary%20protein-driven%20influx%20of%20myeloid%20cells%20facilitates%20flavivirus%20transmission&rft.jtitle=The%20EMBO%20journal&rft.au=Wang,%20Zhaoyang&rft.date=2024-05-02&rft.volume=43&rft.issue=9&rft.spage=1690&rft.epage=1721&rft.pages=1690-1721&rft.issn=1460-2075&rft.eissn=1460-2075&rft_id=info:doi/10.1038/s44318-024-00056-x&rft_dat=%3Cproquest_cross%3E2929538151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2929538151&rft_id=info:pmid/38378891&rfr_iscdi=true |