A molecular arm: the molecular bending–unbending mechanism of integrin

The balance of integrin activation and deactivation regulates its function and mediates cell behaviors. Mechanical force triggers the unbending and activation of integrin. However, how an activated and extended integrin spontaneously bends back is unclear. I performed all-atom molecular dynamics sim...

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Veröffentlicht in:	Biomechanics and modeling in mechanobiology 2024-06, Vol.23 (3), p.781-792
1. Verfasser:	Li, Zhenhai
Format:	Artikel
Sprache:	eng
Schlagworte:	Bending Bends Biological and Medical Physics Biomechanical Phenomena Biomedical Engineering and Bioengineering Biophysics Bones Cytoskeleton Energy Engineering Extracellular matrix Humans Integrins - metabolism Leg Leukocytes Ligands Mechanical properties Mechanics Molecular dynamics Molecular Dynamics Simulation Original Paper Proteins Simulation Theoretical and Applied Mechanics
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