Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism
Background Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA and the effect of continuous positive airway pressure (CPAP) treatment. Methods...
Gespeichert in:
| Veröffentlicht in: | Sleep & breathing 2024-06, Vol.28 (3), p.1231-1243 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1243 |
|---|---|
| container_issue | 3 |
| container_start_page | 1231 |
| container_title | Sleep & breathing |
| container_volume | 28 |
| creator | Shen, Chong Zong, Dandan Peng, Yating Zhou, Li Liu, Ting Ouyang, Ruoyun |
| description | Background
Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA and the effect of continuous positive airway pressure (CPAP) treatment.
Methods
OSA patients and healthy controls were recruited. OSA patients recommended for CPAP treatment were followed up for three months. Flow cytometry was employed to determine the proportion of Th17 and Treg cells. Real-time quantitative polymerase chain reaction (PCR) and western blotting were utilized to detect the mRNA and protein levels of receptor-related orphan receptor γt (RORγt) and forkhead/winged helix transcription factor (Foxp3), respectively, in peripheral blood mononuclear cells (PBMCs). Enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of interleukin-17 (IL-17), IL-6, transforming growth factor-β1 (TGF-β1), and hypoxia-induced factor-1α (HIF-1α).
Results
A total of 56 OSA patients and 40 healthy controls were recruited. The proportion of Th17 cells, Th17/Treg ratio, mRNA and protein levels of RORγt, and serum IL-17, IL-6, and HIF-1α levels were higher in OSA patients. Conversely, the proportion of Treg cells, mRNA and protein levels of Foxp3, and serum TGF-β1 levels were decreased in OSA patients. The proportion of Th17 and Treg cells in OSA can be predicted by the apnea hypopnea index (AHI), IL-6, TGF-β1 and, HIF-1α. 30 moderate-to-severe OSA patients were adherent to three-month CPAP treatment, with improved Th17/Treg imbalance, IL-17, IL-6, TGF-β1, and HIF-1α levels compared to pre-treatment values.
Conclusion
There was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF-β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients. |
| doi_str_mv | 10.1007/s11325-024-02997-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2929130351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3071653599</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-589ae4f941eadfbce417e1abfdef154aacffffc8bbfc0c988e2172d4405fef453</originalsourceid><addsrcrecordid>eNp9kc9qFTEUxoMotlZfwIUE3HQzNid_OpOllFqFQjfXdchkTnpTZjJjkrHct_FRzb23KrhoICRwft-Xc_IR8h7YJ2CsvcgAgquGcVm31m0jXpBTUJw30DL98nBnjVbAT8ibnB8YA9lpeE1ORCdY1yo4Jb-uvUdX6Oypm2MJcZ3XTJc5hxJ-IrUhPdodXRLmvCakJaEtE8YqiHSzhfZik_Cehqm3o40OaYh0sSVUItPHULZ07nNJqzu45RFxoXaJaKmNA7V74zFMIdq0o7msw27vG6p2Qre1MeTpLXnl7Zjx3dN5Rr5_ud5cfW1u726-XX2-bZzgl6VRnbYovZaAdvC9Qwktgu39gB6UtNb5ulzX994xp7sOObR8kJIpj14qcUbOj75Lmn-smIuZQnY41rGwfonhmmsQTCio6Mf_0Id5TbF2ZwRr4VIJpXWl-JFyac45oTdLClMd1AAz-_zMMT9T8zOH_Iyoog9P1ms_4fBX8iewCogjkGsp3mP69_Yztr8BbwuqrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3071653599</pqid></control><display><type>article</type><title>Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Shen, Chong ; Zong, Dandan ; Peng, Yating ; Zhou, Li ; Liu, Ting ; Ouyang, Ruoyun</creator><creatorcontrib>Shen, Chong ; Zong, Dandan ; Peng, Yating ; Zhou, Li ; Liu, Ting ; Ouyang, Ruoyun</creatorcontrib><description>Background
Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA and the effect of continuous positive airway pressure (CPAP) treatment.
Methods
OSA patients and healthy controls were recruited. OSA patients recommended for CPAP treatment were followed up for three months. Flow cytometry was employed to determine the proportion of Th17 and Treg cells. Real-time quantitative polymerase chain reaction (PCR) and western blotting were utilized to detect the mRNA and protein levels of receptor-related orphan receptor γt (RORγt) and forkhead/winged helix transcription factor (Foxp3), respectively, in peripheral blood mononuclear cells (PBMCs). Enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of interleukin-17 (IL-17), IL-6, transforming growth factor-β1 (TGF-β1), and hypoxia-induced factor-1α (HIF-1α).
Results
A total of 56 OSA patients and 40 healthy controls were recruited. The proportion of Th17 cells, Th17/Treg ratio, mRNA and protein levels of RORγt, and serum IL-17, IL-6, and HIF-1α levels were higher in OSA patients. Conversely, the proportion of Treg cells, mRNA and protein levels of Foxp3, and serum TGF-β1 levels were decreased in OSA patients. The proportion of Th17 and Treg cells in OSA can be predicted by the apnea hypopnea index (AHI), IL-6, TGF-β1 and, HIF-1α. 30 moderate-to-severe OSA patients were adherent to three-month CPAP treatment, with improved Th17/Treg imbalance, IL-17, IL-6, TGF-β1, and HIF-1α levels compared to pre-treatment values.
Conclusion
There was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF-β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients.</description><identifier>ISSN: 1520-9512</identifier><identifier>ISSN: 1522-1709</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-024-02997-3</identifier><identifier>PMID: 38308751</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Apnea ; Continuous Positive Airway Pressure ; Dentistry ; Enzyme-linked immunosorbent assay ; Female ; Flow cytometry ; Forkhead protein ; Forkhead Transcription Factors - blood ; Forkhead Transcription Factors - genetics ; Foxp3 protein ; Helper cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit - blood ; Hypoxia-Inducible Factor 1, alpha Subunit - genetics ; Hypoxia-inducible factor 1a ; Immune system ; Inflammatory diseases ; Interleukin 17 ; Interleukin 6 ; Interleukin-17 - blood ; Interleukin-6 - blood ; Internal Medicine ; Leukocytes (mononuclear) ; Lymphocytes T ; Male ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Nuclear Receptor Subfamily 1, Group F, Member 3 - blood ; Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics ; Otorhinolaryngology ; Pediatrics ; Peripheral blood mononuclear cells ; Pneumology/Respiratory System ; Polymerase chain reaction ; Proteins ; Respiratory tract ; Serum levels ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - immunology ; Sleep Apnea, Obstructive - therapy ; Sleep Breathing Physiology and Disorders • Original Article ; Sleep disorders ; T-Lymphocytes, Regulatory - immunology ; Th17 Cells - immunology ; Transforming Growth Factor beta1 - blood ; Transforming Growth Factor beta1 - genetics ; Transforming growth factor-b1 ; Western blotting</subject><ispartof>Sleep & breathing, 2024-06, Vol.28 (3), p.1231-1243</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-589ae4f941eadfbce417e1abfdef154aacffffc8bbfc0c988e2172d4405fef453</cites><orcidid>0000-0001-8997-9574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-024-02997-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-024-02997-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38308751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Chong</creatorcontrib><creatorcontrib>Zong, Dandan</creatorcontrib><creatorcontrib>Peng, Yating</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Liu, Ting</creatorcontrib><creatorcontrib>Ouyang, Ruoyun</creatorcontrib><title>Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Background
Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA and the effect of continuous positive airway pressure (CPAP) treatment.
Methods
OSA patients and healthy controls were recruited. OSA patients recommended for CPAP treatment were followed up for three months. Flow cytometry was employed to determine the proportion of Th17 and Treg cells. Real-time quantitative polymerase chain reaction (PCR) and western blotting were utilized to detect the mRNA and protein levels of receptor-related orphan receptor γt (RORγt) and forkhead/winged helix transcription factor (Foxp3), respectively, in peripheral blood mononuclear cells (PBMCs). Enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of interleukin-17 (IL-17), IL-6, transforming growth factor-β1 (TGF-β1), and hypoxia-induced factor-1α (HIF-1α).
Results
A total of 56 OSA patients and 40 healthy controls were recruited. The proportion of Th17 cells, Th17/Treg ratio, mRNA and protein levels of RORγt, and serum IL-17, IL-6, and HIF-1α levels were higher in OSA patients. Conversely, the proportion of Treg cells, mRNA and protein levels of Foxp3, and serum TGF-β1 levels were decreased in OSA patients. The proportion of Th17 and Treg cells in OSA can be predicted by the apnea hypopnea index (AHI), IL-6, TGF-β1 and, HIF-1α. 30 moderate-to-severe OSA patients were adherent to three-month CPAP treatment, with improved Th17/Treg imbalance, IL-17, IL-6, TGF-β1, and HIF-1α levels compared to pre-treatment values.
Conclusion
There was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF-β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients.</description><subject>Adult</subject><subject>Apnea</subject><subject>Continuous Positive Airway Pressure</subject><subject>Dentistry</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Forkhead protein</subject><subject>Forkhead Transcription Factors - blood</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Foxp3 protein</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - blood</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>Hypoxia-inducible factor 1a</subject><subject>Immune system</subject><subject>Inflammatory diseases</subject><subject>Interleukin 17</subject><subject>Interleukin 6</subject><subject>Interleukin-17 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Internal Medicine</subject><subject>Leukocytes (mononuclear)</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 3 - blood</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Peripheral blood mononuclear cells</subject><subject>Pneumology/Respiratory System</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Respiratory tract</subject><subject>Serum levels</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - immunology</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep Breathing Physiology and Disorders • Original Article</subject><subject>Sleep disorders</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Transforming Growth Factor beta1 - blood</subject><subject>Transforming Growth Factor beta1 - genetics</subject><subject>Transforming growth factor-b1</subject><subject>Western blotting</subject><issn>1520-9512</issn><issn>1522-1709</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9qFTEUxoMotlZfwIUE3HQzNid_OpOllFqFQjfXdchkTnpTZjJjkrHct_FRzb23KrhoICRwft-Xc_IR8h7YJ2CsvcgAgquGcVm31m0jXpBTUJw30DL98nBnjVbAT8ibnB8YA9lpeE1ORCdY1yo4Jb-uvUdX6Oypm2MJcZ3XTJc5hxJ-IrUhPdodXRLmvCakJaEtE8YqiHSzhfZik_Cehqm3o40OaYh0sSVUItPHULZ07nNJqzu45RFxoXaJaKmNA7V74zFMIdq0o7msw27vG6p2Qre1MeTpLXnl7Zjx3dN5Rr5_ud5cfW1u726-XX2-bZzgl6VRnbYovZaAdvC9Qwktgu39gB6UtNb5ulzX994xp7sOObR8kJIpj14qcUbOj75Lmn-smIuZQnY41rGwfonhmmsQTCio6Mf_0Id5TbF2ZwRr4VIJpXWl-JFyac45oTdLClMd1AAz-_zMMT9T8zOH_Iyoog9P1ms_4fBX8iewCogjkGsp3mP69_Yztr8BbwuqrQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Shen, Chong</creator><creator>Zong, Dandan</creator><creator>Peng, Yating</creator><creator>Zhou, Li</creator><creator>Liu, Ting</creator><creator>Ouyang, Ruoyun</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8997-9574</orcidid></search><sort><creationdate>20240601</creationdate><title>Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism</title><author>Shen, Chong ; Zong, Dandan ; Peng, Yating ; Zhou, Li ; Liu, Ting ; Ouyang, Ruoyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-589ae4f941eadfbce417e1abfdef154aacffffc8bbfc0c988e2172d4405fef453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Apnea</topic><topic>Continuous Positive Airway Pressure</topic><topic>Dentistry</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Forkhead protein</topic><topic>Forkhead Transcription Factors - blood</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Foxp3 protein</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - blood</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</topic><topic>Hypoxia-inducible factor 1a</topic><topic>Immune system</topic><topic>Inflammatory diseases</topic><topic>Interleukin 17</topic><topic>Interleukin 6</topic><topic>Interleukin-17 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Internal Medicine</topic><topic>Leukocytes (mononuclear)</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 3 - blood</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Peripheral blood mononuclear cells</topic><topic>Pneumology/Respiratory System</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>Respiratory tract</topic><topic>Serum levels</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - immunology</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep Breathing Physiology and Disorders • Original Article</topic><topic>Sleep disorders</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th17 Cells - immunology</topic><topic>Transforming Growth Factor beta1 - blood</topic><topic>Transforming Growth Factor beta1 - genetics</topic><topic>Transforming growth factor-b1</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Chong</creatorcontrib><creatorcontrib>Zong, Dandan</creatorcontrib><creatorcontrib>Peng, Yating</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Liu, Ting</creatorcontrib><creatorcontrib>Ouyang, Ruoyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Chong</au><au>Zong, Dandan</au><au>Peng, Yating</au><au>Zhou, Li</au><au>Liu, Ting</au><au>Ouyang, Ruoyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>28</volume><issue>3</issue><spage>1231</spage><epage>1243</epage><pages>1231-1243</pages><issn>1520-9512</issn><issn>1522-1709</issn><eissn>1522-1709</eissn><abstract>Background
Obstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune system. This study aims to assess the Th17/Treg pattern in patients with OSA and the effect of continuous positive airway pressure (CPAP) treatment.
Methods
OSA patients and healthy controls were recruited. OSA patients recommended for CPAP treatment were followed up for three months. Flow cytometry was employed to determine the proportion of Th17 and Treg cells. Real-time quantitative polymerase chain reaction (PCR) and western blotting were utilized to detect the mRNA and protein levels of receptor-related orphan receptor γt (RORγt) and forkhead/winged helix transcription factor (Foxp3), respectively, in peripheral blood mononuclear cells (PBMCs). Enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of interleukin-17 (IL-17), IL-6, transforming growth factor-β1 (TGF-β1), and hypoxia-induced factor-1α (HIF-1α).
Results
A total of 56 OSA patients and 40 healthy controls were recruited. The proportion of Th17 cells, Th17/Treg ratio, mRNA and protein levels of RORγt, and serum IL-17, IL-6, and HIF-1α levels were higher in OSA patients. Conversely, the proportion of Treg cells, mRNA and protein levels of Foxp3, and serum TGF-β1 levels were decreased in OSA patients. The proportion of Th17 and Treg cells in OSA can be predicted by the apnea hypopnea index (AHI), IL-6, TGF-β1 and, HIF-1α. 30 moderate-to-severe OSA patients were adherent to three-month CPAP treatment, with improved Th17/Treg imbalance, IL-17, IL-6, TGF-β1, and HIF-1α levels compared to pre-treatment values.
Conclusion
There was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF-β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38308751</pmid><doi>10.1007/s11325-024-02997-3</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8997-9574</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1520-9512 |
| ispartof | Sleep & breathing, 2024-06, Vol.28 (3), p.1231-1243 |
| issn | 1520-9512 1522-1709 1522-1709 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2929130351 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Apnea Continuous Positive Airway Pressure Dentistry Enzyme-linked immunosorbent assay Female Flow cytometry Forkhead protein Forkhead Transcription Factors - blood Forkhead Transcription Factors - genetics Foxp3 protein Helper cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - blood Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-inducible factor 1a Immune system Inflammatory diseases Interleukin 17 Interleukin 6 Interleukin-17 - blood Interleukin-6 - blood Internal Medicine Leukocytes (mononuclear) Lymphocytes T Male Mechanical ventilation Medicine Medicine & Public Health Middle Aged Neurology Nuclear Receptor Subfamily 1, Group F, Member 3 - blood Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Otorhinolaryngology Pediatrics Peripheral blood mononuclear cells Pneumology/Respiratory System Polymerase chain reaction Proteins Respiratory tract Serum levels Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - immunology Sleep Apnea, Obstructive - therapy Sleep Breathing Physiology and Disorders • Original Article Sleep disorders T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology Transforming Growth Factor beta1 - blood Transforming Growth Factor beta1 - genetics Transforming growth factor-b1 Western blotting |
| title | Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T17%3A52%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20continuous%20positive%20airway%20pressure%20treatment%20on%20Th17/Treg%20imbalance%20in%20patients%20with%20obstructive%20sleep%20apnea%20and%20a%20preliminary%20study%20on%20its%20mechanism&rft.jtitle=Sleep%20&%20breathing&rft.au=Shen,%20Chong&rft.date=2024-06-01&rft.volume=28&rft.issue=3&rft.spage=1231&rft.epage=1243&rft.pages=1231-1243&rft.issn=1520-9512&rft.eissn=1522-1709&rft_id=info:doi/10.1007/s11325-024-02997-3&rft_dat=%3Cproquest_cross%3E3071653599%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3071653599&rft_id=info:pmid/38308751&rfr_iscdi=true |