Dichloroacetate ameliorates apoptosis, EMT and oxidative stress in diabetic cataract via inhibiting the IDO1-dependent p38 MAPK pathway

As an oral antidiabetic agent, dichloroacetate (DCA) has been proven to improve diabetes and related complications. However, its functional role in diabetic cataract (DC) remains to be elucidated. This study was to define the role of DCA and its underlying molecular mechanism in DC in vitro and in v...

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Veröffentlicht in:	Molecular and cellular endocrinology 2024-05, Vol.586, p.112174-112174, Article 112174
Hauptverfasser:	Liu, Guang-ming, Shao, Mengting, Liu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Diabetic cataract Dichloroacetate Epithelial-mesenchymal transition IDO1 Oxidative stress p38 MAPK
Online-Zugang:	Volltext
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