Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity
[Display omitted] •OL extracts presented anti-inflammatory, anti-cholinergic, and antioxidant activities.•Anti-cholinesterase activity of OL extracts was affected by flavonoids content.•COX-2 inhibitory activity was affected by secoiridoids.•Secoiridoid compounds and flavonoids equally affected to t...
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| Veröffentlicht in: | Food chemistry 2024-06, Vol.444, p.138516-138516, Article 138516 |
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| creator | Romero-Márquez, Jose M. Navarro-Hortal, María D. Forbes-Hernández, Tamara Y. Varela-López, Alfonso Puentes, Juan G. Sánchez-González, Cristina Sumalla-Cano, Sandra Battino, Maurizio García-Ruiz, Roberto Sánchez, Sebastián Quiles, José L. |
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•OL extracts presented anti-inflammatory, anti-cholinergic, and antioxidant activities.•Anti-cholinesterase activity of OL extracts was affected by flavonoids content.•COX-2 inhibitory activity was affected by secoiridoids.•Secoiridoid compounds and flavonoids equally affected to the antioxidant effects.
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects. |
| doi_str_mv | 10.1016/j.foodchem.2024.138516 |
| format | Article |
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•OL extracts presented anti-inflammatory, anti-cholinergic, and antioxidant activities.•Anti-cholinesterase activity of OL extracts was affected by flavonoids content.•COX-2 inhibitory activity was affected by secoiridoids.•Secoiridoid compounds and flavonoids equally affected to the antioxidant effects.
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2024.138516</identifier><identifier>PMID: 38306771</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acetylcholinesterase ; AChE ; Anti-Inflammatory Agents - analysis ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - chemistry ; Cholinergic ; Cholinergic Antagonists - analysis ; COX ; Cyclooxygenase 2 ; Inflammation ; Iridoid Glucosides ; Iridoids - analysis ; Iron ; Leaves ; Olea - chemistry ; Olive ; Oxidative stress ; Phenylethyl Alcohol - analogs & derivatives ; Phytochemicals - analysis ; Plant Extracts - chemistry ; Plant Leaves - chemistry</subject><ispartof>Food chemistry, 2024-06, Vol.444, p.138516-138516, Article 138516</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-1d924343c35fe5a81ddf471c053e6b25df325f137b49d7081e42d97365d938b73</citedby><cites>FETCH-LOGICAL-c416t-1d924343c35fe5a81ddf471c053e6b25df325f137b49d7081e42d97365d938b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2024.138516$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38306771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romero-Márquez, Jose M.</creatorcontrib><creatorcontrib>Navarro-Hortal, María D.</creatorcontrib><creatorcontrib>Forbes-Hernández, Tamara Y.</creatorcontrib><creatorcontrib>Varela-López, Alfonso</creatorcontrib><creatorcontrib>Puentes, Juan G.</creatorcontrib><creatorcontrib>Sánchez-González, Cristina</creatorcontrib><creatorcontrib>Sumalla-Cano, Sandra</creatorcontrib><creatorcontrib>Battino, Maurizio</creatorcontrib><creatorcontrib>García-Ruiz, Roberto</creatorcontrib><creatorcontrib>Sánchez, Sebastián</creatorcontrib><creatorcontrib>Quiles, José L.</creatorcontrib><title>Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>[Display omitted]
•OL extracts presented anti-inflammatory, anti-cholinergic, and antioxidant activities.•Anti-cholinesterase activity of OL extracts was affected by flavonoids content.•COX-2 inhibitory activity was affected by secoiridoids.•Secoiridoid compounds and flavonoids equally affected to the antioxidant effects.
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.</description><subject>Acetylcholinesterase</subject><subject>AChE</subject><subject>Anti-Inflammatory Agents - analysis</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - chemistry</subject><subject>Cholinergic</subject><subject>Cholinergic Antagonists - analysis</subject><subject>COX</subject><subject>Cyclooxygenase 2</subject><subject>Inflammation</subject><subject>Iridoid Glucosides</subject><subject>Iridoids - analysis</subject><subject>Iron</subject><subject>Leaves</subject><subject>Olea - chemistry</subject><subject>Olive</subject><subject>Oxidative stress</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phytochemicals - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves - chemistry</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQhlHVqNkm_QsRxx7qLV82-NYqSj-kSL00Z8QOQ5aV12zBG8X3_PCycdJrTyMNz8wLPIRccbbmjHefd-uQkoct7teCCbXm0rS8e0NW3GjZaKbFW7JikpnGcNWdk_el7BhjgnHzjpxLI1mnNV-Rp5sQECaaAk1DfEA6oAv0sJ2ndFoewQ2FppFOW6RunGLjAKd5gG2lRywTZlfw03IEMwwpPc73ONZmI2rX04A5R6AZ_RHieP9Mpsfoa6XgDg7iNF-Ss1Bz8MNLvSB3325-X_9obn99_3n99bYBxbup4b4XSioJsg3YOsO9D0pzYK3EbiNaH6RoA5d6o3qvmeGohO-17FrfS7PR8oJ8XPYecvpzrLe3-1gAh8GNmI7Fil70XBglT2i3oJBTKRmDPeS4d3m2nNmTAbuzrwbsyYBdDNTBq5eM42aP_t_Y65dX4MsCYH3pQ8RsC0QcAX3M1YT1Kf4v4y-1eZzE</recordid><startdate>20240630</startdate><enddate>20240630</enddate><creator>Romero-Márquez, Jose M.</creator><creator>Navarro-Hortal, María D.</creator><creator>Forbes-Hernández, Tamara Y.</creator><creator>Varela-López, Alfonso</creator><creator>Puentes, Juan G.</creator><creator>Sánchez-González, Cristina</creator><creator>Sumalla-Cano, Sandra</creator><creator>Battino, Maurizio</creator><creator>García-Ruiz, Roberto</creator><creator>Sánchez, Sebastián</creator><creator>Quiles, José L.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240630</creationdate><title>Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity</title><author>Romero-Márquez, Jose M. ; Navarro-Hortal, María D. ; Forbes-Hernández, Tamara Y. ; Varela-López, Alfonso ; Puentes, Juan G. ; Sánchez-González, Cristina ; Sumalla-Cano, Sandra ; Battino, Maurizio ; García-Ruiz, Roberto ; Sánchez, Sebastián ; Quiles, José L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-1d924343c35fe5a81ddf471c053e6b25df325f137b49d7081e42d97365d938b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acetylcholinesterase</topic><topic>AChE</topic><topic>Anti-Inflammatory Agents - analysis</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - chemistry</topic><topic>Cholinergic</topic><topic>Cholinergic Antagonists - analysis</topic><topic>COX</topic><topic>Cyclooxygenase 2</topic><topic>Inflammation</topic><topic>Iridoid Glucosides</topic><topic>Iridoids - analysis</topic><topic>Iron</topic><topic>Leaves</topic><topic>Olea - chemistry</topic><topic>Olive</topic><topic>Oxidative stress</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phytochemicals - analysis</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romero-Márquez, Jose M.</creatorcontrib><creatorcontrib>Navarro-Hortal, María D.</creatorcontrib><creatorcontrib>Forbes-Hernández, Tamara Y.</creatorcontrib><creatorcontrib>Varela-López, Alfonso</creatorcontrib><creatorcontrib>Puentes, Juan G.</creatorcontrib><creatorcontrib>Sánchez-González, Cristina</creatorcontrib><creatorcontrib>Sumalla-Cano, Sandra</creatorcontrib><creatorcontrib>Battino, Maurizio</creatorcontrib><creatorcontrib>García-Ruiz, Roberto</creatorcontrib><creatorcontrib>Sánchez, Sebastián</creatorcontrib><creatorcontrib>Quiles, José L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romero-Márquez, Jose M.</au><au>Navarro-Hortal, María D.</au><au>Forbes-Hernández, Tamara Y.</au><au>Varela-López, Alfonso</au><au>Puentes, Juan G.</au><au>Sánchez-González, Cristina</au><au>Sumalla-Cano, Sandra</au><au>Battino, Maurizio</au><au>García-Ruiz, Roberto</au><au>Sánchez, Sebastián</au><au>Quiles, José L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2024-06-30</date><risdate>2024</risdate><volume>444</volume><spage>138516</spage><epage>138516</epage><pages>138516-138516</pages><artnum>138516</artnum><issn>0308-8146</issn><eissn>1873-7072</eissn><abstract>[Display omitted]
•OL extracts presented anti-inflammatory, anti-cholinergic, and antioxidant activities.•Anti-cholinesterase activity of OL extracts was affected by flavonoids content.•COX-2 inhibitory activity was affected by secoiridoids.•Secoiridoid compounds and flavonoids equally affected to the antioxidant effects.
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38306771</pmid><doi>10.1016/j.foodchem.2024.138516</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholinesterase AChE Anti-Inflammatory Agents - analysis Anti-Inflammatory Agents - pharmacology Antioxidants - chemistry Cholinergic Cholinergic Antagonists - analysis COX Cyclooxygenase 2 Inflammation Iridoid Glucosides Iridoids - analysis Iron Leaves Olea - chemistry Olive Oxidative stress Phenylethyl Alcohol - analogs & derivatives Phytochemicals - analysis Plant Extracts - chemistry Plant Leaves - chemistry |
| title | Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity |
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