Case report: Intraneural perineurioma in dogs: a case series and brief literature review

Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural peri...

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Veröffentlicht in:Frontiers in veterinary science 2023, Vol.10, p.1233230-1233230
Hauptverfasser: Yin, Ji-Hang, Sexton, Brittani, Jukier, Tom, Yanke, Amy B, Holland, Merrilee, Miller, Andrew D, Stranahan, Lauren, Hoffmann, Aline Rodrigues, Sandey, Maninder
Format: Report
Sprache:eng
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Zusammenfassung:Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma.
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2023.1233230