Intergenerational inheritance induced by a high-fat diet causes hyperphagia and reduced hypothalamic sensitivity to insulin and leptin in the second-generation of rats

•A high-fat diet causes hyperphagia in second-generation offspring.•A high-fat diet induced intergenerational inheritance in second-generation offspring.•A high-fat diet reduced hypothalamic sensitivity to insulin and leptin of second-generation offspring. The aim was to investigate the intergenerat...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2024-04, Vol.120, p.112333-112333, Article 112333
Hauptverfasser:	Maia, Rosana da Conceição Araújo, Lima, Taynara Carolina, Barbosa, Claudiane Maria, Barbosa, Maria Andréa, de Queiroz, Karina Barbosa, Alzamora, Andréia Carvalho
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adipose tissue Agouti-related protein Agouti-Related Protein - metabolism AKT protein Angiotensin Angiotensin II Angiotensins - metabolism Animals Appetite Beta cells Blood pressure Body fat Body mass Carbohydrates Carbonyl compounds Carbonyls Deoxyribonucleic acid Diet Diet, High-Fat - adverse effects DNA DNA methylation DNA methyltransferase DNA Methyltransferase 3A DNA methyltransferase enzymes Enzymes Epigenetics Females Food Food intake Gene expression Glucose Heredity High fat diet Homeostasis Hyperphagia Hyperphagia - complications Hypothalamus Hypothalamus - metabolism Insulin Insulin - metabolism Insulin and leptin sensitivity Insulin Receptor Substrate Proteins - metabolism Insulin receptors Insulin Resistance Intergenerational inheritance Kinases Leptin - metabolism Metabolism NAD(P)H oxidase NADPH oxidase NADPH-diaphorase Neuropeptides Neuropeptides - metabolism Nicotinamide Nicotinamide adenine dinucleotide Nutrition research Obesity - genetics Obesity - metabolism Offspring Peptidyl-dipeptidase A Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proteins Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 2 - metabolism Receptor, Insulin - genetics Receptor, Insulin - metabolism Receptors Receptors, Leptin - genetics Satiety Sensitivity Signal transduction Substrates Superoxide dismutase Superoxide Dismutase - metabolism Weaning
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