Association of metabolic health and obesity with coronary heart disease in adult cancer survivors
Background The metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate...
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| Veröffentlicht in: | European journal of clinical investigation 2024-05, Vol.54 (5), p.e14161-n/a |
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| creator | Kim, Kyuwoong Di Giovanna, Edvige Jung, Hyeyun Bethineedi, Lakshimi Deepak Jun, Tae Joon Kim, Young‐Hak |
| description | Background
The metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate the associations between different metabolic health and obesity phenotypes with incident CHD in adult cancer survivors.
Methods
We used National Health Insurance Service (NHIS) to identify a cohort of 173,951 adult cancer survivors aged more than 20 years free of cardiovascular complications. Metabolically healthy nonobese (MHN), MHO, metabolically unhealthy nonobese (MUN), metabolically unhealthy obese (MUO) phenotypes were created using as at least three out of five metabolic health criteria along with obesity (body mass index ≥ 25.0 kg/m2). We used Cox proportional hazards model to assess CHD risk in each metabolic health and obesity phenotypes.
Results
During 1,376,050 person‐years of follow‐up, adult cancer survivors with MHO phenotype had a significantly higher risk of CHD (hazard ratio [HR] = 1.52; 95% confidence intervals [CI]: 1.41 to 1.65) as compared to those without obesity and metabolic abnormalities. MUN (HR = 1.81; 95% CI: 1.59 to 2.06) and MUO (HR = 1.92; 95% CI: 1.72 to 2.15) phenotypes were also associated with an increased risk of CHD among adult cancer survivors.
Conclusions
Adult cancer survivors with MHO phenotype had a higher risk of CHD than those who are MHN. Metabolic health status and obesity were jointly associated with CHD risk in adult cancer survivors.
This study used data on 173,951 adult cancer survivors from the National Health Insurance Service database. During a follow‐up of more than 1.3 million person‐years, metabolically healthy obese individuals had a 52% higher risk of coronary heart disease (CHD) as compared to those without obesity and metabolic abnormalities. Metabolically unhealthy nonobese and metabolically unhealthy obese phenotypes were also significantly associated with an increased risk of CHD. Our findings underline the importance of managing obesity and metabolic health in cancer survivorship. |
| doi_str_mv | 10.1111/eci.14161 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2929059276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2929059276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3131-df97f0005d8adef523c33229a89bdf16d69446b679eb0b2a872d0995eaade5a53</originalsourceid><addsrcrecordid>eNp10MtKAzEUBuAgiq3VhS8gATe6mDaXuWUppWqh4EbXIZOcoSnTSU1mWvr2pra6EMzmQPj4OedH6JaSMY1vAtqOaUpzeoaGlOdZwnjOztGQEJomTBRsgK5CWBFCSsrZJRrwknFBymKI1FMITlvVWddiV-M1dKpyjdV4Carplli1BrsKgu32eGfjh3betcrvD8B32NgAKgC2LVambzqsVavB49D7rd06H67RRa2aADenOUIfz7P36WuyeHuZT58WieaU08TUoqjjhpkplYE6Y1xzzphQpahMTXOTizTNq7wQUJGKqbJghgiRgYo8UxkfoYdj7sa7zx5CJ9c2aGga1YLrg2SCCZIJVuSR3v-hK9f7Nm4nOeGCkpSIg3o8Ku1dCB5qufF2HS-XlMhD7zL2Lr97j_bulNhXazC_8qfoCCZHsLMN7P9PkrPp_Bj5BRUsjH8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3039104096</pqid></control><display><type>article</type><title>Association of metabolic health and obesity with coronary heart disease in adult cancer survivors</title><source>Wiley Online Library All Journals</source><creator>Kim, Kyuwoong ; Di Giovanna, Edvige ; Jung, Hyeyun ; Bethineedi, Lakshimi Deepak ; Jun, Tae Joon ; Kim, Young‐Hak</creator><creatorcontrib>Kim, Kyuwoong ; Di Giovanna, Edvige ; Jung, Hyeyun ; Bethineedi, Lakshimi Deepak ; Jun, Tae Joon ; Kim, Young‐Hak</creatorcontrib><description>Background
The metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate the associations between different metabolic health and obesity phenotypes with incident CHD in adult cancer survivors.
Methods
We used National Health Insurance Service (NHIS) to identify a cohort of 173,951 adult cancer survivors aged more than 20 years free of cardiovascular complications. Metabolically healthy nonobese (MHN), MHO, metabolically unhealthy nonobese (MUN), metabolically unhealthy obese (MUO) phenotypes were created using as at least three out of five metabolic health criteria along with obesity (body mass index ≥ 25.0 kg/m2). We used Cox proportional hazards model to assess CHD risk in each metabolic health and obesity phenotypes.
Results
During 1,376,050 person‐years of follow‐up, adult cancer survivors with MHO phenotype had a significantly higher risk of CHD (hazard ratio [HR] = 1.52; 95% confidence intervals [CI]: 1.41 to 1.65) as compared to those without obesity and metabolic abnormalities. MUN (HR = 1.81; 95% CI: 1.59 to 2.06) and MUO (HR = 1.92; 95% CI: 1.72 to 2.15) phenotypes were also associated with an increased risk of CHD among adult cancer survivors.
Conclusions
Adult cancer survivors with MHO phenotype had a higher risk of CHD than those who are MHN. Metabolic health status and obesity were jointly associated with CHD risk in adult cancer survivors.
This study used data on 173,951 adult cancer survivors from the National Health Insurance Service database. During a follow‐up of more than 1.3 million person‐years, metabolically healthy obese individuals had a 52% higher risk of coronary heart disease (CHD) as compared to those without obesity and metabolic abnormalities. Metabolically unhealthy nonobese and metabolically unhealthy obese phenotypes were also significantly associated with an increased risk of CHD. Our findings underline the importance of managing obesity and metabolic health in cancer survivorship.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.14161</identifier><identifier>PMID: 38239087</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Abnormalities ; Body mass index ; Body size ; Cancer ; cancer survivor ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery disease ; coronary heart disease ; Genotype & phenotype ; Hazard assessment ; Heart diseases ; Metabolism ; Obesity ; phenotype ; Phenotypes ; Statistical models ; Survival ; weight</subject><ispartof>European journal of clinical investigation, 2024-05, Vol.54 (5), p.e14161-n/a</ispartof><rights>2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><rights>2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3131-df97f0005d8adef523c33229a89bdf16d69446b679eb0b2a872d0995eaade5a53</cites><orcidid>0000-0002-2824-8441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.14161$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.14161$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38239087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Kyuwoong</creatorcontrib><creatorcontrib>Di Giovanna, Edvige</creatorcontrib><creatorcontrib>Jung, Hyeyun</creatorcontrib><creatorcontrib>Bethineedi, Lakshimi Deepak</creatorcontrib><creatorcontrib>Jun, Tae Joon</creatorcontrib><creatorcontrib>Kim, Young‐Hak</creatorcontrib><title>Association of metabolic health and obesity with coronary heart disease in adult cancer survivors</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
The metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate the associations between different metabolic health and obesity phenotypes with incident CHD in adult cancer survivors.
Methods
We used National Health Insurance Service (NHIS) to identify a cohort of 173,951 adult cancer survivors aged more than 20 years free of cardiovascular complications. Metabolically healthy nonobese (MHN), MHO, metabolically unhealthy nonobese (MUN), metabolically unhealthy obese (MUO) phenotypes were created using as at least three out of five metabolic health criteria along with obesity (body mass index ≥ 25.0 kg/m2). We used Cox proportional hazards model to assess CHD risk in each metabolic health and obesity phenotypes.
Results
During 1,376,050 person‐years of follow‐up, adult cancer survivors with MHO phenotype had a significantly higher risk of CHD (hazard ratio [HR] = 1.52; 95% confidence intervals [CI]: 1.41 to 1.65) as compared to those without obesity and metabolic abnormalities. MUN (HR = 1.81; 95% CI: 1.59 to 2.06) and MUO (HR = 1.92; 95% CI: 1.72 to 2.15) phenotypes were also associated with an increased risk of CHD among adult cancer survivors.
Conclusions
Adult cancer survivors with MHO phenotype had a higher risk of CHD than those who are MHN. Metabolic health status and obesity were jointly associated with CHD risk in adult cancer survivors.
This study used data on 173,951 adult cancer survivors from the National Health Insurance Service database. During a follow‐up of more than 1.3 million person‐years, metabolically healthy obese individuals had a 52% higher risk of coronary heart disease (CHD) as compared to those without obesity and metabolic abnormalities. Metabolically unhealthy nonobese and metabolically unhealthy obese phenotypes were also significantly associated with an increased risk of CHD. Our findings underline the importance of managing obesity and metabolic health in cancer survivorship.</description><subject>Abnormalities</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cancer</subject><subject>cancer survivor</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery disease</subject><subject>coronary heart disease</subject><subject>Genotype & phenotype</subject><subject>Hazard assessment</subject><subject>Heart diseases</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>phenotype</subject><subject>Phenotypes</subject><subject>Statistical models</subject><subject>Survival</subject><subject>weight</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp10MtKAzEUBuAgiq3VhS8gATe6mDaXuWUppWqh4EbXIZOcoSnTSU1mWvr2pra6EMzmQPj4OedH6JaSMY1vAtqOaUpzeoaGlOdZwnjOztGQEJomTBRsgK5CWBFCSsrZJRrwknFBymKI1FMITlvVWddiV-M1dKpyjdV4Carplli1BrsKgu32eGfjh3betcrvD8B32NgAKgC2LVambzqsVavB49D7rd06H67RRa2aADenOUIfz7P36WuyeHuZT58WieaU08TUoqjjhpkplYE6Y1xzzphQpahMTXOTizTNq7wQUJGKqbJghgiRgYo8UxkfoYdj7sa7zx5CJ9c2aGga1YLrg2SCCZIJVuSR3v-hK9f7Nm4nOeGCkpSIg3o8Ku1dCB5qufF2HS-XlMhD7zL2Lr97j_bulNhXazC_8qfoCCZHsLMN7P9PkrPp_Bj5BRUsjH8</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Kim, Kyuwoong</creator><creator>Di Giovanna, Edvige</creator><creator>Jung, Hyeyun</creator><creator>Bethineedi, Lakshimi Deepak</creator><creator>Jun, Tae Joon</creator><creator>Kim, Young‐Hak</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2824-8441</orcidid></search><sort><creationdate>202405</creationdate><title>Association of metabolic health and obesity with coronary heart disease in adult cancer survivors</title><author>Kim, Kyuwoong ; Di Giovanna, Edvige ; Jung, Hyeyun ; Bethineedi, Lakshimi Deepak ; Jun, Tae Joon ; Kim, Young‐Hak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3131-df97f0005d8adef523c33229a89bdf16d69446b679eb0b2a872d0995eaade5a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abnormalities</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cancer</topic><topic>cancer survivor</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coronary artery disease</topic><topic>coronary heart disease</topic><topic>Genotype & phenotype</topic><topic>Hazard assessment</topic><topic>Heart diseases</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>phenotype</topic><topic>Phenotypes</topic><topic>Statistical models</topic><topic>Survival</topic><topic>weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kyuwoong</creatorcontrib><creatorcontrib>Di Giovanna, Edvige</creatorcontrib><creatorcontrib>Jung, Hyeyun</creatorcontrib><creatorcontrib>Bethineedi, Lakshimi Deepak</creatorcontrib><creatorcontrib>Jun, Tae Joon</creatorcontrib><creatorcontrib>Kim, Young‐Hak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kyuwoong</au><au>Di Giovanna, Edvige</au><au>Jung, Hyeyun</au><au>Bethineedi, Lakshimi Deepak</au><au>Jun, Tae Joon</au><au>Kim, Young‐Hak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of metabolic health and obesity with coronary heart disease in adult cancer survivors</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2024-05</date><risdate>2024</risdate><volume>54</volume><issue>5</issue><spage>e14161</spage><epage>n/a</epage><pages>e14161-n/a</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
The metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate the associations between different metabolic health and obesity phenotypes with incident CHD in adult cancer survivors.
Methods
We used National Health Insurance Service (NHIS) to identify a cohort of 173,951 adult cancer survivors aged more than 20 years free of cardiovascular complications. Metabolically healthy nonobese (MHN), MHO, metabolically unhealthy nonobese (MUN), metabolically unhealthy obese (MUO) phenotypes were created using as at least three out of five metabolic health criteria along with obesity (body mass index ≥ 25.0 kg/m2). We used Cox proportional hazards model to assess CHD risk in each metabolic health and obesity phenotypes.
Results
During 1,376,050 person‐years of follow‐up, adult cancer survivors with MHO phenotype had a significantly higher risk of CHD (hazard ratio [HR] = 1.52; 95% confidence intervals [CI]: 1.41 to 1.65) as compared to those without obesity and metabolic abnormalities. MUN (HR = 1.81; 95% CI: 1.59 to 2.06) and MUO (HR = 1.92; 95% CI: 1.72 to 2.15) phenotypes were also associated with an increased risk of CHD among adult cancer survivors.
Conclusions
Adult cancer survivors with MHO phenotype had a higher risk of CHD than those who are MHN. Metabolic health status and obesity were jointly associated with CHD risk in adult cancer survivors.
This study used data on 173,951 adult cancer survivors from the National Health Insurance Service database. During a follow‐up of more than 1.3 million person‐years, metabolically healthy obese individuals had a 52% higher risk of coronary heart disease (CHD) as compared to those without obesity and metabolic abnormalities. Metabolically unhealthy nonobese and metabolically unhealthy obese phenotypes were also significantly associated with an increased risk of CHD. Our findings underline the importance of managing obesity and metabolic health in cancer survivorship.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>38239087</pmid><doi>10.1111/eci.14161</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-2824-8441</orcidid></addata></record> |
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| subjects | Abnormalities Body mass index Body size Cancer cancer survivor Cardiovascular disease Cardiovascular diseases Coronary artery disease coronary heart disease Genotype & phenotype Hazard assessment Heart diseases Metabolism Obesity phenotype Phenotypes Statistical models Survival weight |
| title | Association of metabolic health and obesity with coronary heart disease in adult cancer survivors |
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