Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension
Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular mortality and morbidity in patients with hypertension. However, the effect of age on LVH regression or persistence and its differential prognostic value remain unclear. Therefore, we investigated the clinical implicat...
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| Veröffentlicht in: | Hypertension research 2024-05, Vol.47 (5), p.1144-1156 |
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| container_title | Hypertension research |
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| creator | Chu, Hyun-Wook Hwang, In-Chang Kim, Hyue Mee Park, Jiesuck Choi, Hyejung Choi, Hong-Mi Yoon, Yeonyee E Cho, Goo-Yeong |
| description | Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular mortality and morbidity in patients with hypertension. However, the effect of age on LVH regression or persistence and its differential prognostic value remain unclear. Therefore, we investigated the clinical implications of LVH regression in 1847 patients with hypertension and echocardiography data (at baseline and during antihypertensive treatment at an interval of 6-18 months) according to age. LVH was defined as a left ventricular mass index (LVMI) > 115 g/m
and >95 g/m
in men and women, respectively. LVH prevalence at baseline was not different according to age (age < 65 years: 42.6%; age ≥65 years: 45.7%; p = 0.187), but LVH regression was more frequently observed in the younger group (36.4% vs. 27.5%; p = 0.008). Spline curves and multiple linear regression analysis showed a significant relationship between reductions in systolic blood pressure and LVMI in the younger group (β = 0.425; p |
| doi_str_mv | 10.1038/s41440-023-01571-w |
| format | Article |
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and >95 g/m
in men and women, respectively. LVH prevalence at baseline was not different according to age (age < 65 years: 42.6%; age ≥65 years: 45.7%; p = 0.187), but LVH regression was more frequently observed in the younger group (36.4% vs. 27.5%; p = 0.008). Spline curves and multiple linear regression analysis showed a significant relationship between reductions in systolic blood pressure and LVMI in the younger group (β = 0.425; p < 0.001), but not the elderly group (β = 0.044; p = 0.308). LVH regression was associated with a lower risk of the study outcome (composite of cardiovascular death and hospitalization for heart failure) regardless of age. In conclusion, the association between the reduction in blood pressure and LVH regression was prominent in patients with age < 65 years, but not in those with age ≥65 years. However, an association between LVH regression and lower risk of cardiovascular death and hospitalization for heart failure was observed regardless of patient age, suggesting the prognostic value of the LVH regression not only in the younger patients but also in elderly patients.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-023-01571-w</identifier><identifier>PMID: 38238511</identifier><language>eng</language><publisher>England</publisher><ispartof>Hypertension research, 2024-05, Vol.47 (5), p.1144-1156</ispartof><rights>2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-c4956431b7dab8c78bd8f65dc64750953d3f4f28e95787d4f67be888b3ba12723</citedby><cites>FETCH-LOGICAL-c303t-c4956431b7dab8c78bd8f65dc64750953d3f4f28e95787d4f67be888b3ba12723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38238511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chu, Hyun-Wook</creatorcontrib><creatorcontrib>Hwang, In-Chang</creatorcontrib><creatorcontrib>Kim, Hyue Mee</creatorcontrib><creatorcontrib>Park, Jiesuck</creatorcontrib><creatorcontrib>Choi, Hyejung</creatorcontrib><creatorcontrib>Choi, Hong-Mi</creatorcontrib><creatorcontrib>Yoon, Yeonyee E</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><title>Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular mortality and morbidity in patients with hypertension. However, the effect of age on LVH regression or persistence and its differential prognostic value remain unclear. Therefore, we investigated the clinical implications of LVH regression in 1847 patients with hypertension and echocardiography data (at baseline and during antihypertensive treatment at an interval of 6-18 months) according to age. LVH was defined as a left ventricular mass index (LVMI) > 115 g/m
and >95 g/m
in men and women, respectively. LVH prevalence at baseline was not different according to age (age < 65 years: 42.6%; age ≥65 years: 45.7%; p = 0.187), but LVH regression was more frequently observed in the younger group (36.4% vs. 27.5%; p = 0.008). Spline curves and multiple linear regression analysis showed a significant relationship between reductions in systolic blood pressure and LVMI in the younger group (β = 0.425; p < 0.001), but not the elderly group (β = 0.044; p = 0.308). LVH regression was associated with a lower risk of the study outcome (composite of cardiovascular death and hospitalization for heart failure) regardless of age. In conclusion, the association between the reduction in blood pressure and LVH regression was prominent in patients with age < 65 years, but not in those with age ≥65 years. However, an association between LVH regression and lower risk of cardiovascular death and hospitalization for heart failure was observed regardless of patient age, suggesting the prognostic value of the LVH regression not only in the younger patients but also in elderly patients.</description><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kDtPwzAYRS0EoqXwBxiQRxaDX4ntsUK8pEosMFuJ87k1ygs7oeq_J6WF6Q733DschK4ZvWNU6PskmZSUUC4IZZliZHuC5kxITSRn8hTNqWE5MbnIZ-gipU9Kuc4MO0czobnQGWNz5JZrIBX00FbQDjg0fR1cMYSuTbjzuAY_4O-picGNdRHxZtdDHGLXb3Y4wjpCShOLQ4v7aTWBCW_DsDly0O7bS3TmizrB1TEX6OPp8f3hhazenl8fliviBBUDcdJkuRSsVFVRaqd0WWmfZ5XLpcqoyUQlvPRcg8mUVpX0uSpBa12KsmBccbFAt4ffPnZfI6TBNiE5qOuihW5Mlhtu6CRAsgnlB9TFLqUI3vYxNEXcWUbtXq49yLWTXPsr126n0c3xfywbqP4nfzbFD-rNd5Q</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Chu, Hyun-Wook</creator><creator>Hwang, In-Chang</creator><creator>Kim, Hyue Mee</creator><creator>Park, Jiesuck</creator><creator>Choi, Hyejung</creator><creator>Choi, Hong-Mi</creator><creator>Yoon, Yeonyee E</creator><creator>Cho, Goo-Yeong</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240501</creationdate><title>Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension</title><author>Chu, Hyun-Wook ; Hwang, In-Chang ; Kim, Hyue Mee ; Park, Jiesuck ; Choi, Hyejung ; Choi, Hong-Mi ; Yoon, Yeonyee E ; Cho, Goo-Yeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-c4956431b7dab8c78bd8f65dc64750953d3f4f28e95787d4f67be888b3ba12723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chu, Hyun-Wook</creatorcontrib><creatorcontrib>Hwang, In-Chang</creatorcontrib><creatorcontrib>Kim, Hyue Mee</creatorcontrib><creatorcontrib>Park, Jiesuck</creatorcontrib><creatorcontrib>Choi, Hyejung</creatorcontrib><creatorcontrib>Choi, Hong-Mi</creatorcontrib><creatorcontrib>Yoon, Yeonyee E</creatorcontrib><creatorcontrib>Cho, Goo-Yeong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Hyun-Wook</au><au>Hwang, In-Chang</au><au>Kim, Hyue Mee</au><au>Park, Jiesuck</au><au>Choi, Hyejung</au><au>Choi, Hong-Mi</au><au>Yoon, Yeonyee E</au><au>Cho, Goo-Yeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>47</volume><issue>5</issue><spage>1144</spage><epage>1156</epage><pages>1144-1156</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular mortality and morbidity in patients with hypertension. However, the effect of age on LVH regression or persistence and its differential prognostic value remain unclear. Therefore, we investigated the clinical implications of LVH regression in 1847 patients with hypertension and echocardiography data (at baseline and during antihypertensive treatment at an interval of 6-18 months) according to age. LVH was defined as a left ventricular mass index (LVMI) > 115 g/m
and >95 g/m
in men and women, respectively. LVH prevalence at baseline was not different according to age (age < 65 years: 42.6%; age ≥65 years: 45.7%; p = 0.187), but LVH regression was more frequently observed in the younger group (36.4% vs. 27.5%; p = 0.008). Spline curves and multiple linear regression analysis showed a significant relationship between reductions in systolic blood pressure and LVMI in the younger group (β = 0.425; p < 0.001), but not the elderly group (β = 0.044; p = 0.308). LVH regression was associated with a lower risk of the study outcome (composite of cardiovascular death and hospitalization for heart failure) regardless of age. In conclusion, the association between the reduction in blood pressure and LVH regression was prominent in patients with age < 65 years, but not in those with age ≥65 years. However, an association between LVH regression and lower risk of cardiovascular death and hospitalization for heart failure was observed regardless of patient age, suggesting the prognostic value of the LVH regression not only in the younger patients but also in elderly patients.</abstract><cop>England</cop><pmid>38238511</pmid><doi>10.1038/s41440-023-01571-w</doi><tpages>13</tpages></addata></record> |
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| title | Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension |
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