Ophthalmic acid is a glutathione regulating tripeptide

Since its discovery in 1958 in the lens of cows, ophthalmic acid (OPH) has stood in the shadow of its anti‐oxidant analog: glutathione (GSH). Lacking the thiol group that gives GSH many of its important properties, ophthalmic acid's function has remained elusive, and it has been widely presumed...

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Veröffentlicht in:	The FEBS journal 2024-08, Vol.291 (15), p.3317-3330
Hauptverfasser:	Schomakers, Bauke V., Jillings, Sonia L., Weeghel, Michel, Vaz, Frédéric M., Salomons, Gajja S., Janssens, Georges E., Houtkooper, Riekelt H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cellular metabolism diabetes Efflux Glutathione Glutathione - metabolism Humans Metabolites metabolomics Oligopeptides - metabolism ophthalmate ophthalmic acid Oxidants Oxidative metabolism Oxidative Stress Oxidizing agents Pyrrolidonecarboxylic Acid - analogs & derivatives Pyrrolidonecarboxylic Acid - metabolism
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