Integrated proteogenomic characterization of glioblastoma evolution

The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic analysis of 123 longitudinal glioblastoma pairs and identify a highly proliferative cellular state at diagnosis and repl...

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Veröffentlicht in:	Cancer cell 2024-03, Vol.42 (3), p.358-377.e8
Hauptverfasser:	Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, Park, Jong Bae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BRAF Brain Neoplasms - genetics Cell Line, Tumor Disease Models, Animal Drug Resistance, Neoplasm Glioblastoma - genetics Humans longitudinal glioblastoma Neoplasm Recurrence, Local neuronal Proteogenomics Proteomics Proto-Oncogene Proteins B-raf recurrence synapse Xenograft Model Antitumor Assays
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