Inflammation as an aetiological trigger for depressive symptoms in a prospective cohort of patients with inflammatory bowel disease
Inflammatory bowel disease (IBD) is often comorbid with mood disorders and depressive symptoms. The aetiology of depressive symptoms in IBD, however, remains largely unknown. Consistent with the inflammatory hypothesis of depression, the aim of this study was to explore the prospective associations...
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| Veröffentlicht in: | Journal of psychosomatic research 2024-02, Vol.177, p.111592, Article 111592 |
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| creator | Ballesio, Andrea Micheli, Federica Baccini, Flavia Zagaria, Andrea Del Forno, Alessandro Fiori, Valeria Palombelli, Gloria Scalamonti, Silvia Ruffa, Andrea Magiotta, Ambra Di Nardo, Giovanni Lombardo, Caterina |
| description | Inflammatory bowel disease (IBD) is often comorbid with mood disorders and depressive symptoms. The aetiology of depressive symptoms in IBD, however, remains largely unknown. Consistent with the inflammatory hypothesis of depression, the aim of this study was to explore the prospective associations between inflammatory biomarkers and depressive symptoms in a cohort of IBD patients with and without a previous clinical diagnosis of mood disorder.
IBD clinical activity was determined using the Harvey-Bradshaw Index for CD and the Partial Mayo score for UC; serum C-reactive protein (CRP) and faecal calprotectin (fCAL) were used as biomarkers of systemic and intestinal inflammation, respectively. Participants were administered the Hospital Anxiety and Depression Scale-depression (HADS-D) at baseline and 1-year follow-up.
Eighty-four participants (50 ± 16 years; 75% UC and 25% CD) were included in the main analyses. Longitudinal moderated regression models showed that baseline CRP significantly predicted follow-up HADS-D scores among individuals with a previous mood disorder diagnosis (β = 0.843, p |
| doi_str_mv | 10.1016/j.jpsychores.2024.111592 |
| format | Article |
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IBD clinical activity was determined using the Harvey-Bradshaw Index for CD and the Partial Mayo score for UC; serum C-reactive protein (CRP) and faecal calprotectin (fCAL) were used as biomarkers of systemic and intestinal inflammation, respectively. Participants were administered the Hospital Anxiety and Depression Scale-depression (HADS-D) at baseline and 1-year follow-up.
Eighty-four participants (50 ± 16 years; 75% UC and 25% CD) were included in the main analyses. Longitudinal moderated regression models showed that baseline CRP significantly predicted follow-up HADS-D scores among individuals with a previous mood disorder diagnosis (β = 0.843, p < .001), but not among individuals without (β = −0.013, p = .896), after controlling for baseline HADS-D scores, body mass index, IBD phenotype, sex, and perceived stress. Likely due to lower power, results on FCAL (n = 31) were not statistically significant.
This study suggests that IBD patients with previous diagnosis of mood disorder may be at higher risk of inflammation-related depressive symptoms.
•The aetiology of depressive symptoms in IBD remains elusive.•Enhanced innate immune response may drive depressive symptoms in IBD.•CRP longitudinally predicted depression only in those with a previous mood disorder.•Results on faecal calprotectin were underpowered and non-significant.</description><identifier>ISSN: 0022-3999</identifier><identifier>ISSN: 1879-1360</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2024.111592</identifier><identifier>PMID: 38217896</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Biomarkers ; C-Reactive Protein - metabolism ; Colitis, Ulcerative ; Crohn Disease ; Crohn's disease ; CRP ; Depression ; Depression - complications ; Humans ; IBD ; Inflammation ; Inflammation - complications ; Inflammatory Bowel Diseases - complications ; Severity of Illness Index ; Ulcerative colitis</subject><ispartof>Journal of psychosomatic research, 2024-02, Vol.177, p.111592, Article 111592</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-bc1395ac1139396b0e83a5f3d1ec1953671c4cb45620fe8de6473ba4638c73613</citedby><cites>FETCH-LOGICAL-c424t-bc1395ac1139396b0e83a5f3d1ec1953671c4cb45620fe8de6473ba4638c73613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychores.2024.111592$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38217896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ballesio, Andrea</creatorcontrib><creatorcontrib>Micheli, Federica</creatorcontrib><creatorcontrib>Baccini, Flavia</creatorcontrib><creatorcontrib>Zagaria, Andrea</creatorcontrib><creatorcontrib>Del Forno, Alessandro</creatorcontrib><creatorcontrib>Fiori, Valeria</creatorcontrib><creatorcontrib>Palombelli, Gloria</creatorcontrib><creatorcontrib>Scalamonti, Silvia</creatorcontrib><creatorcontrib>Ruffa, Andrea</creatorcontrib><creatorcontrib>Magiotta, Ambra</creatorcontrib><creatorcontrib>Di Nardo, Giovanni</creatorcontrib><creatorcontrib>Lombardo, Caterina</creatorcontrib><title>Inflammation as an aetiological trigger for depressive symptoms in a prospective cohort of patients with inflammatory bowel disease</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>Inflammatory bowel disease (IBD) is often comorbid with mood disorders and depressive symptoms. The aetiology of depressive symptoms in IBD, however, remains largely unknown. Consistent with the inflammatory hypothesis of depression, the aim of this study was to explore the prospective associations between inflammatory biomarkers and depressive symptoms in a cohort of IBD patients with and without a previous clinical diagnosis of mood disorder.
IBD clinical activity was determined using the Harvey-Bradshaw Index for CD and the Partial Mayo score for UC; serum C-reactive protein (CRP) and faecal calprotectin (fCAL) were used as biomarkers of systemic and intestinal inflammation, respectively. Participants were administered the Hospital Anxiety and Depression Scale-depression (HADS-D) at baseline and 1-year follow-up.
Eighty-four participants (50 ± 16 years; 75% UC and 25% CD) were included in the main analyses. Longitudinal moderated regression models showed that baseline CRP significantly predicted follow-up HADS-D scores among individuals with a previous mood disorder diagnosis (β = 0.843, p < .001), but not among individuals without (β = −0.013, p = .896), after controlling for baseline HADS-D scores, body mass index, IBD phenotype, sex, and perceived stress. Likely due to lower power, results on FCAL (n = 31) were not statistically significant.
This study suggests that IBD patients with previous diagnosis of mood disorder may be at higher risk of inflammation-related depressive symptoms.
•The aetiology of depressive symptoms in IBD remains elusive.•Enhanced innate immune response may drive depressive symptoms in IBD.•CRP longitudinally predicted depression only in those with a previous mood disorder.•Results on faecal calprotectin were underpowered and non-significant.</description><subject>Biomarkers</subject><subject>C-Reactive Protein - metabolism</subject><subject>Colitis, Ulcerative</subject><subject>Crohn Disease</subject><subject>Crohn's disease</subject><subject>CRP</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Humans</subject><subject>IBD</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Severity of Illness Index</subject><subject>Ulcerative colitis</subject><issn>0022-3999</issn><issn>1879-1360</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v2zAMhoVhxZKm-wuDjr041YctW8ctWLsCAXbZzoIs04kCO_JEJUXO_eNTkGw99iJC4EO-JF9CKGdLzrh62C13E57cNkTApWCiXHLOKy0-kDlval1wqdhHMmdMiEJqrWfkFnHHGFNaVJ_ITDaC141Wc_L6vO8HO442-bCnFqnNL-TPEDbe2YGm6DcbiLQPkXYwZUH0R6B4GqcURqQ-83SKASdw6ZxxIY-VaOjplJvCPiF98WmbwatQiCfahhcYaOcRLMIduentgPD5Ghfk9-P3X6sfxfrn0_Pq67pwpShT0ToudWUdz0Fq1TJopK162XFwXFdS1dyVri0rJVgPTQeqrGVrSyUbV0vF5YLcX_rmcf8cAJMZPToYBruHcEAjtNBMSibOaHNBXd4MI_Rmin608WQ4M2cLzM68WWDOFpiLBbn0y1Xl0I7Q_S_8d_MMfLsAkHc9eogGXb6Tg87HfEPTBf--yl_EPaAe</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Ballesio, Andrea</creator><creator>Micheli, Federica</creator><creator>Baccini, Flavia</creator><creator>Zagaria, Andrea</creator><creator>Del Forno, Alessandro</creator><creator>Fiori, Valeria</creator><creator>Palombelli, Gloria</creator><creator>Scalamonti, Silvia</creator><creator>Ruffa, Andrea</creator><creator>Magiotta, Ambra</creator><creator>Di Nardo, Giovanni</creator><creator>Lombardo, Caterina</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202402</creationdate><title>Inflammation as an aetiological trigger for depressive symptoms in a prospective cohort of patients with inflammatory bowel disease</title><author>Ballesio, Andrea ; Micheli, Federica ; Baccini, Flavia ; Zagaria, Andrea ; Del Forno, Alessandro ; Fiori, Valeria ; Palombelli, Gloria ; Scalamonti, Silvia ; Ruffa, Andrea ; Magiotta, Ambra ; Di Nardo, Giovanni ; Lombardo, Caterina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-bc1395ac1139396b0e83a5f3d1ec1953671c4cb45620fe8de6473ba4638c73613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers</topic><topic>C-Reactive Protein - metabolism</topic><topic>Colitis, Ulcerative</topic><topic>Crohn Disease</topic><topic>Crohn's disease</topic><topic>CRP</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Humans</topic><topic>IBD</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Severity of Illness Index</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ballesio, Andrea</creatorcontrib><creatorcontrib>Micheli, Federica</creatorcontrib><creatorcontrib>Baccini, Flavia</creatorcontrib><creatorcontrib>Zagaria, Andrea</creatorcontrib><creatorcontrib>Del Forno, Alessandro</creatorcontrib><creatorcontrib>Fiori, Valeria</creatorcontrib><creatorcontrib>Palombelli, Gloria</creatorcontrib><creatorcontrib>Scalamonti, Silvia</creatorcontrib><creatorcontrib>Ruffa, Andrea</creatorcontrib><creatorcontrib>Magiotta, Ambra</creatorcontrib><creatorcontrib>Di Nardo, Giovanni</creatorcontrib><creatorcontrib>Lombardo, Caterina</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ballesio, Andrea</au><au>Micheli, Federica</au><au>Baccini, Flavia</au><au>Zagaria, Andrea</au><au>Del Forno, Alessandro</au><au>Fiori, Valeria</au><au>Palombelli, Gloria</au><au>Scalamonti, Silvia</au><au>Ruffa, Andrea</au><au>Magiotta, Ambra</au><au>Di Nardo, Giovanni</au><au>Lombardo, Caterina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation as an aetiological trigger for depressive symptoms in a prospective cohort of patients with inflammatory bowel disease</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>2024-02</date><risdate>2024</risdate><volume>177</volume><spage>111592</spage><pages>111592-</pages><artnum>111592</artnum><issn>0022-3999</issn><issn>1879-1360</issn><eissn>1879-1360</eissn><abstract>Inflammatory bowel disease (IBD) is often comorbid with mood disorders and depressive symptoms. The aetiology of depressive symptoms in IBD, however, remains largely unknown. Consistent with the inflammatory hypothesis of depression, the aim of this study was to explore the prospective associations between inflammatory biomarkers and depressive symptoms in a cohort of IBD patients with and without a previous clinical diagnosis of mood disorder.
IBD clinical activity was determined using the Harvey-Bradshaw Index for CD and the Partial Mayo score for UC; serum C-reactive protein (CRP) and faecal calprotectin (fCAL) were used as biomarkers of systemic and intestinal inflammation, respectively. Participants were administered the Hospital Anxiety and Depression Scale-depression (HADS-D) at baseline and 1-year follow-up.
Eighty-four participants (50 ± 16 years; 75% UC and 25% CD) were included in the main analyses. Longitudinal moderated regression models showed that baseline CRP significantly predicted follow-up HADS-D scores among individuals with a previous mood disorder diagnosis (β = 0.843, p < .001), but not among individuals without (β = −0.013, p = .896), after controlling for baseline HADS-D scores, body mass index, IBD phenotype, sex, and perceived stress. Likely due to lower power, results on FCAL (n = 31) were not statistically significant.
This study suggests that IBD patients with previous diagnosis of mood disorder may be at higher risk of inflammation-related depressive symptoms.
•The aetiology of depressive symptoms in IBD remains elusive.•Enhanced innate immune response may drive depressive symptoms in IBD.•CRP longitudinally predicted depression only in those with a previous mood disorder.•Results on faecal calprotectin were underpowered and non-significant.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>38217896</pmid><doi>10.1016/j.jpsychores.2024.111592</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of psychosomatic research, 2024-02, Vol.177, p.111592, Article 111592 |
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| subjects | Biomarkers C-Reactive Protein - metabolism Colitis, Ulcerative Crohn Disease Crohn's disease CRP Depression Depression - complications Humans IBD Inflammation Inflammation - complications Inflammatory Bowel Diseases - complications Severity of Illness Index Ulcerative colitis |
| title | Inflammation as an aetiological trigger for depressive symptoms in a prospective cohort of patients with inflammatory bowel disease |
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