Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms
Objectives We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfact...
Gespeichert in:
| Veröffentlicht in: | HIV medicine 2024-05, Vol.25 (5), p.565-576 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 576 |
|---|---|
| container_issue | 5 |
| container_start_page | 565 |
| container_title | HIV medicine |
| container_volume | 25 |
| creator | Galindo Puerto, M. José Puig, J. Pérez‐Molina, J. A. Fuster‐Ruiz de Apodaca, M. J. |
| description | Objectives
We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfaction.
Methods
Ex post‐facto cross‐sectional surveys were administered to 502 people living with HIV and 101 HIV clinicians in Spain (18 sites).
Results
The median age of participants with HIV was 43.2 years, 74.5% were male, and 91.6% had an undetectable viral load. The mean time since initiation of ART was 10.2 years. Between 54% and 67% of people living with HIV reported experiencing nervousness or anxiety, sadness, fatigue, sleep problems, or muscle/joint pain during the preceding 4 weeks. However, only 22%–27% of specialists acknowledged the presence of these symptoms. The most bothersome symptoms were related to mental health or the central nervous system. There were significant differences between the burden of symptoms reported by people living with HIV and those acknowledged by specialists. The symptoms that more frequently caused ART discontinuation were depression, dizziness, and sleep problems. Both people living with HIV and specialists prioritized ART efficacy and low toxicity, but their importance ratings differed for 5 of the 11 ART characteristics assessed. People living with HIV rated their satisfaction with ART at a mean (± standard deviation) of 8.9 ± 1.5 out of 10, whereas HIV specialists rated it lower, at 8.3 ± 0.7 (p |
| doi_str_mv | 10.1111/hiv.13609 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2929030263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3051774323</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3139-cf49ef61e21b638a50d33eec53a59aba9df44403e98e59b53639cdc5112ed993</originalsourceid><addsrcrecordid>eNp1kc9KAzEQh4MoWqsHX0AWvOhhbZLJbjdHEbWFgh7Ea0izszRl_5mkLQUPPoLP6JO4ttWD4FxmDt98DPMj5IzRa9bVYGaX1wxSKvdIj4k0ixmXsL-ZRczTlB-RY-_nlLIhSHpIjiDjTAjIeuTtCZ1v0QS7RB81RdRi05YYrWyYRaPxS6TrfNNNaWtrrK47qo7MTDttAjrrgzWbRV0H6zC4ZmmdLqPgUIcK6_Bj-Hz_cFjqgHnk11UbmsqfkINClx5Pd71Pnu_vnm9H8eTxYXx7M4kNMJCxKYTEImXI2TSFTCc0B0A0CehE6qmWeSGEoIAyw0ROE0hBmtwkjHHMpYQ-udxqW9e8LtAHVVlvsCx1jc3CKy65pEB5Ch168QedNwtXd8cpoAkbDgXwb-pqSxnXeO-wUK2zlXZrxaj6TkR1iahNIh17vjMuphXmv-RPBB0w2AIrW-L6f5PqfrhVfgFRH5ch</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3051774323</pqid></control><display><type>article</type><title>Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Galindo Puerto, M. José ; Puig, J. ; Pérez‐Molina, J. A. ; Fuster‐Ruiz de Apodaca, M. J.</creator><creatorcontrib>Galindo Puerto, M. José ; Puig, J. ; Pérez‐Molina, J. A. ; Fuster‐Ruiz de Apodaca, M. J.</creatorcontrib><description>Objectives
We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfaction.
Methods
Ex post‐facto cross‐sectional surveys were administered to 502 people living with HIV and 101 HIV clinicians in Spain (18 sites).
Results
The median age of participants with HIV was 43.2 years, 74.5% were male, and 91.6% had an undetectable viral load. The mean time since initiation of ART was 10.2 years. Between 54% and 67% of people living with HIV reported experiencing nervousness or anxiety, sadness, fatigue, sleep problems, or muscle/joint pain during the preceding 4 weeks. However, only 22%–27% of specialists acknowledged the presence of these symptoms. The most bothersome symptoms were related to mental health or the central nervous system. There were significant differences between the burden of symptoms reported by people living with HIV and those acknowledged by specialists. The symptoms that more frequently caused ART discontinuation were depression, dizziness, and sleep problems. Both people living with HIV and specialists prioritized ART efficacy and low toxicity, but their importance ratings differed for 5 of the 11 ART characteristics assessed. People living with HIV rated their satisfaction with ART at a mean (± standard deviation) of 8.9 ± 1.5 out of 10, whereas HIV specialists rated it lower, at 8.3 ± 0.7 (p < 0.001).
Conclusions
Despite advances in HIV care and treatment, a large proportion of patients still experience symptoms. HIV specialists may not be fully aware of these. People living with HIV and HIV specialists are, overall, satisfied with ART. However, the importance they place on different ART characteristics may vary.</description><identifier>ISSN: 1464-2662</identifier><identifier>ISSN: 1468-1293</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/hiv.13609</identifier><identifier>PMID: 38214438</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Anti-HIV Agents - therapeutic use ; Anti-Retroviral Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral therapy ; anti‐retroviral agents ; Arthralgia ; Central nervous system ; Cross-Sectional Studies ; Female ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - psychology ; Human immunodeficiency virus ; Humans ; Male ; Mean ; Middle Aged ; Muscular fatigue ; patient preference ; Patient Satisfaction ; patient‐centered care ; physicians ; practice patterns ; quality of health care ; Sleep ; Sleep disorders ; Spain ; Surveys and Questionnaires ; Symptomology ; Symptoms ; Toxicity</subject><ispartof>HIV medicine, 2024-05, Vol.25 (5), p.565-576</ispartof><rights>2024 British HIV Association.</rights><rights>2024 British HIV Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3139-cf49ef61e21b638a50d33eec53a59aba9df44403e98e59b53639cdc5112ed993</cites><orcidid>0000-0002-4075-0346 ; 0000-0002-4911-4071 ; 0000-0001-8735-4124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhiv.13609$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhiv.13609$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38214438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galindo Puerto, M. José</creatorcontrib><creatorcontrib>Puig, J.</creatorcontrib><creatorcontrib>Pérez‐Molina, J. A.</creatorcontrib><creatorcontrib>Fuster‐Ruiz de Apodaca, M. J.</creatorcontrib><title>Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms</title><title>HIV medicine</title><addtitle>HIV Med</addtitle><description>Objectives
We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfaction.
Methods
Ex post‐facto cross‐sectional surveys were administered to 502 people living with HIV and 101 HIV clinicians in Spain (18 sites).
Results
The median age of participants with HIV was 43.2 years, 74.5% were male, and 91.6% had an undetectable viral load. The mean time since initiation of ART was 10.2 years. Between 54% and 67% of people living with HIV reported experiencing nervousness or anxiety, sadness, fatigue, sleep problems, or muscle/joint pain during the preceding 4 weeks. However, only 22%–27% of specialists acknowledged the presence of these symptoms. The most bothersome symptoms were related to mental health or the central nervous system. There were significant differences between the burden of symptoms reported by people living with HIV and those acknowledged by specialists. The symptoms that more frequently caused ART discontinuation were depression, dizziness, and sleep problems. Both people living with HIV and specialists prioritized ART efficacy and low toxicity, but their importance ratings differed for 5 of the 11 ART characteristics assessed. People living with HIV rated their satisfaction with ART at a mean (± standard deviation) of 8.9 ± 1.5 out of 10, whereas HIV specialists rated it lower, at 8.3 ± 0.7 (p < 0.001).
Conclusions
Despite advances in HIV care and treatment, a large proportion of patients still experience symptoms. HIV specialists may not be fully aware of these. People living with HIV and HIV specialists are, overall, satisfied with ART. However, the importance they place on different ART characteristics may vary.</description><subject>Adult</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>anti‐retroviral agents</subject><subject>Arthralgia</subject><subject>Central nervous system</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - psychology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Mean</subject><subject>Middle Aged</subject><subject>Muscular fatigue</subject><subject>patient preference</subject><subject>Patient Satisfaction</subject><subject>patient‐centered care</subject><subject>physicians</subject><subject>practice patterns</subject><subject>quality of health care</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Spain</subject><subject>Surveys and Questionnaires</subject><subject>Symptomology</subject><subject>Symptoms</subject><subject>Toxicity</subject><issn>1464-2662</issn><issn>1468-1293</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9KAzEQh4MoWqsHX0AWvOhhbZLJbjdHEbWFgh7Ea0izszRl_5mkLQUPPoLP6JO4ttWD4FxmDt98DPMj5IzRa9bVYGaX1wxSKvdIj4k0ixmXsL-ZRczTlB-RY-_nlLIhSHpIjiDjTAjIeuTtCZ1v0QS7RB81RdRi05YYrWyYRaPxS6TrfNNNaWtrrK47qo7MTDttAjrrgzWbRV0H6zC4ZmmdLqPgUIcK6_Bj-Hz_cFjqgHnk11UbmsqfkINClx5Pd71Pnu_vnm9H8eTxYXx7M4kNMJCxKYTEImXI2TSFTCc0B0A0CehE6qmWeSGEoIAyw0ROE0hBmtwkjHHMpYQ-udxqW9e8LtAHVVlvsCx1jc3CKy65pEB5Ch168QedNwtXd8cpoAkbDgXwb-pqSxnXeO-wUK2zlXZrxaj6TkR1iahNIh17vjMuphXmv-RPBB0w2AIrW-L6f5PqfrhVfgFRH5ch</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Galindo Puerto, M. José</creator><creator>Puig, J.</creator><creator>Pérez‐Molina, J. A.</creator><creator>Fuster‐Ruiz de Apodaca, M. J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4075-0346</orcidid><orcidid>https://orcid.org/0000-0002-4911-4071</orcidid><orcidid>https://orcid.org/0000-0001-8735-4124</orcidid></search><sort><creationdate>202405</creationdate><title>Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms</title><author>Galindo Puerto, M. José ; Puig, J. ; Pérez‐Molina, J. A. ; Fuster‐Ruiz de Apodaca, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3139-cf49ef61e21b638a50d33eec53a59aba9df44403e98e59b53639cdc5112ed993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral therapy</topic><topic>anti‐retroviral agents</topic><topic>Arthralgia</topic><topic>Central nervous system</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - psychology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Male</topic><topic>Mean</topic><topic>Middle Aged</topic><topic>Muscular fatigue</topic><topic>patient preference</topic><topic>Patient Satisfaction</topic><topic>patient‐centered care</topic><topic>physicians</topic><topic>practice patterns</topic><topic>quality of health care</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Spain</topic><topic>Surveys and Questionnaires</topic><topic>Symptomology</topic><topic>Symptoms</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galindo Puerto, M. José</creatorcontrib><creatorcontrib>Puig, J.</creatorcontrib><creatorcontrib>Pérez‐Molina, J. A.</creatorcontrib><creatorcontrib>Fuster‐Ruiz de Apodaca, M. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galindo Puerto, M. José</au><au>Puig, J.</au><au>Pérez‐Molina, J. A.</au><au>Fuster‐Ruiz de Apodaca, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2024-05</date><risdate>2024</risdate><volume>25</volume><issue>5</issue><spage>565</spage><epage>576</epage><pages>565-576</pages><issn>1464-2662</issn><issn>1468-1293</issn><eissn>1468-1293</eissn><abstract>Objectives
We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfaction.
Methods
Ex post‐facto cross‐sectional surveys were administered to 502 people living with HIV and 101 HIV clinicians in Spain (18 sites).
Results
The median age of participants with HIV was 43.2 years, 74.5% were male, and 91.6% had an undetectable viral load. The mean time since initiation of ART was 10.2 years. Between 54% and 67% of people living with HIV reported experiencing nervousness or anxiety, sadness, fatigue, sleep problems, or muscle/joint pain during the preceding 4 weeks. However, only 22%–27% of specialists acknowledged the presence of these symptoms. The most bothersome symptoms were related to mental health or the central nervous system. There were significant differences between the burden of symptoms reported by people living with HIV and those acknowledged by specialists. The symptoms that more frequently caused ART discontinuation were depression, dizziness, and sleep problems. Both people living with HIV and specialists prioritized ART efficacy and low toxicity, but their importance ratings differed for 5 of the 11 ART characteristics assessed. People living with HIV rated their satisfaction with ART at a mean (± standard deviation) of 8.9 ± 1.5 out of 10, whereas HIV specialists rated it lower, at 8.3 ± 0.7 (p < 0.001).
Conclusions
Despite advances in HIV care and treatment, a large proportion of patients still experience symptoms. HIV specialists may not be fully aware of these. People living with HIV and HIV specialists are, overall, satisfied with ART. However, the importance they place on different ART characteristics may vary.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38214438</pmid><doi>10.1111/hiv.13609</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4075-0346</orcidid><orcidid>https://orcid.org/0000-0002-4911-4071</orcidid><orcidid>https://orcid.org/0000-0001-8735-4124</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1464-2662 |
| ispartof | HIV medicine, 2024-05, Vol.25 (5), p.565-576 |
| issn | 1464-2662 1468-1293 1468-1293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2929030263 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Anti-HIV Agents - therapeutic use Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral therapy anti‐retroviral agents Arthralgia Central nervous system Cross-Sectional Studies Female HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - psychology Human immunodeficiency virus Humans Male Mean Middle Aged Muscular fatigue patient preference Patient Satisfaction patient‐centered care physicians practice patterns quality of health care Sleep Sleep disorders Spain Surveys and Questionnaires Symptomology Symptoms Toxicity |
| title | Perspectives of people with HIV and HIV clinicians on characteristics of antiretroviral treatment and HIV‐related symptoms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T20%3A59%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Perspectives%20of%20people%20with%20HIV%20and%20HIV%20clinicians%20on%20characteristics%20of%20antiretroviral%20treatment%20and%20HIV%E2%80%90related%20symptoms&rft.jtitle=HIV%20medicine&rft.au=Galindo%20Puerto,%20M.%20Jos%C3%A9&rft.date=2024-05&rft.volume=25&rft.issue=5&rft.spage=565&rft.epage=576&rft.pages=565-576&rft.issn=1464-2662&rft.eissn=1468-1293&rft_id=info:doi/10.1111/hiv.13609&rft_dat=%3Cproquest_cross%3E3051774323%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3051774323&rft_id=info:pmid/38214438&rfr_iscdi=true |