Self‐Assembled Oligopeptoplex‐Loaded Dissolving Microneedles for Adipocyte‐Targeted Anti‐Obesity Gene Therapy

Advancements in gene delivery systems are pivotal for gene‐based therapeutics in oncological, inflammatory, and infectious diseases. This study delineates the design of a self‐assembled oligopeptoplex (SA‐OP) optimized for shRNA delivery to adipocytes, targeting obesity and associated metabolic synd...

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Veröffentlicht in:	Advanced materials (Weinheim) 2024-04, Vol.36 (16), p.e2309920-n/a
Hauptverfasser:	Choi, Heekyung, Hong, Juhyeong, Seo, Yuha, Joo, Seung‐Hwan, Lim, Hanseok, Lahiji, Shayan Fakhraei, Kim, Yong‐Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte targeting anti‐obesity gene knockdown Adipose tissue Body weight dissolving microneedle dual shRNA Effectiveness Gene therapy Hyaluronic acid Infectious diseases Metabolic disorders Metabolism Needles Obesity oligopeptoplexes Self-assembly Storage stability
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