ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported into the cytosol to exert multiple regulatory effects in macrophages. However, the mechanism by which itaconate exits from macrophages remains unknown. Using a genetic screen, we reveal that itaconate is ex...

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Veröffentlicht in:	Cell metabolism 2024-03, Vol.36 (3), p.498-510.e11
Hauptverfasser:	Chen, Chao, Zhang, Zhenxing, Liu, Caiyun, Sun, Pengkai, Liu, Ping, Li, Xinjian
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Animals Anti-Bacterial Agents ATP Binding Cassette Transporter, Subfamily G, Member 2 Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism exporter Humans Immunity, Innate innate immunity itaconate lysosomal biogenesis Lysosomes - metabolism macrophages Mice Neoplasm Proteins - metabolism Succinates - metabolism Succinates - pharmacology TFEB
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