Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line

A well-documented Achilles heel of current cancer immunotherapy approaches is T cell exhaustion within solid tumor tissues. The proinflammatory cytokine interleukin (IL)-23 has been utilized to augment chimeric antigen receptor (CAR) T cell survival and tumor immunity. However, in-depth interrogatio...

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Veröffentlicht in:	Journal of leukocyte biology 2024-05, Vol.115 (6), p.1108-1117
Hauptverfasser:	Sarah, Momtazkari, Anahita, Dev Choudhury, Zachary, Wei Ern Yong, Thanh, Dong Le, Hiep, Nguyen Canh, Kenichi, Harada, Hori, Toshiyuki, Motomi, Osato, Chiaki, Takahashi, Koh, Cai Ping, Dominic, Chih-Cheng Voon
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cell Line Cell Proliferation Cell Survival Humans Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-2 - pharmacology Interleukin-23 - immunology Interleukin-23 - metabolism Signal Transduction Th17 Cells - immunology
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