Uncovering the Mechanism of Chinese Hawthorn Leaf on Myocardial Ischemia Based on Network Pharmacology, Molecular Docking Verification, and In Vitro Studies

Hawthorn leaf has shown therapeutic effects in the patients with myocardial ischemia. Our study combines network pharmacology, molecular docking techniques, and in vitro experiment with the aim of revealing the mechanism of hawthorn leaves in the treatment of myocardial ischemia. The active ingredie...

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Veröffentlicht in:	Cardiovascular toxicology 2024-02, Vol.24 (2), p.171-183
Hauptverfasser:	Gao, Jingyun, Wang, Yueyue, Xiong, Hui, Zhao, Shengnan, He, Mingmei, He, Meiting, Pan, Haifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein AKT1 protein BAX protein Bcl-2 protein Bioinformatics Biomedical and Life Sciences Biomedicine Cardiology Coronary Artery Disease Crataegus Databases, Genetic Drug therapy Drugs, Chinese Herbal - pharmacology Encyclopedias Estrogens Genes Genomes Health aspects Herbal medicine Humans Ingredients Ischemia Kaempferol Leaves Medical research Medicine, Chinese Medicine, Experimental Molecular docking Molecular Docking Simulation Myocardial ischemia Myocardial Ischemia - drug therapy Myocardial Ischemia - genetics Network analysis Network Pharmacology Pharmacology Pharmacology/Toxicology Phosphatidylinositol 3-Kinases Protein-protein interactions Proteins Proto-Oncogene Proteins c-akt Quercetin Quercetin - pharmacology Software Therapeutic targets Traditional Chinese medicine Trimetazidine Verification
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