Risk factors for anxiety in patients with epilepsy: A meta-analysis
•The first meta-analysis of risk factors for anxiety for PWE.•Identified several factors associated with an increased risk of anxiety in PWE.•Further prospective cohort studies are needed to investigate risk factors of anxiety in PWE to help improve quality of life. Epilepsy is a very common neurolo...
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| creator | Niu, Cailang Li, Penghong Du, Xueqing Zhao, Mina Wang, Haobo Yang, Debo Wu, Maolin Jing, Wei |
| description | •The first meta-analysis of risk factors for anxiety for PWE.•Identified several factors associated with an increased risk of anxiety in PWE.•Further prospective cohort studies are needed to investigate risk factors of anxiety in PWE to help improve quality of life.
Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This meta-analysis was performed to identify potential risk factors for anxiety in PWE with the aim of reducing the incidence of anxiety and improving the quality of life among the individuals.
The PubMed, Embase and Cochrane Library databases were systematically searched up to July 2023 to find eligible original English studies. All the search results were reviewed based on our inclusion and exclusion criteria. We calculated the combined odds ratios (ORs), standard mean differences (SMDs) and their corresponding 95% confidence intervals (CIs) to evaluate the effect of the included risk factors on anxiety in PWE.
Twenty-four studies involving 5,403 PWE were ultimately included. The pooled results of our meta-analysis showed that female sex (OR = 1.67; 95 % CI: 1.30,2.15; p |
| doi_str_mv | 10.1016/j.yebeh.2024.109665 |
| format | Article |
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Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This meta-analysis was performed to identify potential risk factors for anxiety in PWE with the aim of reducing the incidence of anxiety and improving the quality of life among the individuals.
The PubMed, Embase and Cochrane Library databases were systematically searched up to July 2023 to find eligible original English studies. All the search results were reviewed based on our inclusion and exclusion criteria. We calculated the combined odds ratios (ORs), standard mean differences (SMDs) and their corresponding 95% confidence intervals (CIs) to evaluate the effect of the included risk factors on anxiety in PWE.
Twenty-four studies involving 5,403 PWE were ultimately included. The pooled results of our meta-analysis showed that female sex (OR = 1.67; 95 % CI: 1.30,2.15; p < 0.001), unmarried/divorced/widowed (OR = 0.83; 95 % CI: 0.72,0.96; p = 0.011), low socioeconomic status (OR = 0.47; 95 % CI: 0.33,0.67; p < 0.001), education levels below high school (OR = 1.74; 95 % CI: 1.36,2.23; p < 0.001), a history of trauma (OR = 2.53; 95 % CI: 1.69,3.78; p < 0.001), monotherapy (OR = 0.49; 95 % CI: 0.39,0.62; p < 0.001), AED-induced psychiatric side effects (OR = 2.45; 95 % CI: 1.20,4.98); p = 0.014), depression (OR = 5.45 95 % CI: 2.49,11.94; p < 0.001), a history of suicide (OR = 3.56; 95 % CI: 1.72,7.38; p = 0.001), and illness-related shame (OR = 2.76; 95 % CI: 2.17,3.52; p < 0.001) were risk factors for anxiety.
This meta-analysis showed that female, unmarried, low socioeconomic status, education level below senior high school, a history of trauma, monotherapy, AED-induced psychiatric side effects, depression, a history of suicide, and shame were risk factors for anxiety in PWE. However, further research is needed to determine the effect of other potential risk factors on anxiety in PWE. In addition, most of the studies included in this meta-analysis were not uniform in scale, and the risk factors were not comprehensive; therefore, larger prospective studies in different countries are needed to further investigate these risk factors.]]></description><identifier>ISSN: 1525-5050</identifier><identifier>ISSN: 1525-5069</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2024.109665</identifier><identifier>PMID: 38368787</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anxiety ; Anxiety - epidemiology ; Anxiety - etiology ; Epilepsy ; Epilepsy - complications ; Epilepsy - epidemiology ; Epilepsy - psychology ; Humans ; Meta-analysis ; Quality of Life - psychology ; Risk Factors</subject><ispartof>Epilepsy & behavior, 2024-04, Vol.153, p.109665, Article 109665</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-3c91f3ec8bbdbaf8b0ddd191457edcbf0a554dcd0accf007fdbd1b389e6598ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525505024000465$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38368787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niu, Cailang</creatorcontrib><creatorcontrib>Li, Penghong</creatorcontrib><creatorcontrib>Du, Xueqing</creatorcontrib><creatorcontrib>Zhao, Mina</creatorcontrib><creatorcontrib>Wang, Haobo</creatorcontrib><creatorcontrib>Yang, Debo</creatorcontrib><creatorcontrib>Wu, Maolin</creatorcontrib><creatorcontrib>Jing, Wei</creatorcontrib><title>Risk factors for anxiety in patients with epilepsy: A meta-analysis</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description><![CDATA[•The first meta-analysis of risk factors for anxiety for PWE.•Identified several factors associated with an increased risk of anxiety in PWE.•Further prospective cohort studies are needed to investigate risk factors of anxiety in PWE to help improve quality of life.
Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This meta-analysis was performed to identify potential risk factors for anxiety in PWE with the aim of reducing the incidence of anxiety and improving the quality of life among the individuals.
The PubMed, Embase and Cochrane Library databases were systematically searched up to July 2023 to find eligible original English studies. All the search results were reviewed based on our inclusion and exclusion criteria. We calculated the combined odds ratios (ORs), standard mean differences (SMDs) and their corresponding 95% confidence intervals (CIs) to evaluate the effect of the included risk factors on anxiety in PWE.
Twenty-four studies involving 5,403 PWE were ultimately included. The pooled results of our meta-analysis showed that female sex (OR = 1.67; 95 % CI: 1.30,2.15; p < 0.001), unmarried/divorced/widowed (OR = 0.83; 95 % CI: 0.72,0.96; p = 0.011), low socioeconomic status (OR = 0.47; 95 % CI: 0.33,0.67; p < 0.001), education levels below high school (OR = 1.74; 95 % CI: 1.36,2.23; p < 0.001), a history of trauma (OR = 2.53; 95 % CI: 1.69,3.78; p < 0.001), monotherapy (OR = 0.49; 95 % CI: 0.39,0.62; p < 0.001), AED-induced psychiatric side effects (OR = 2.45; 95 % CI: 1.20,4.98); p = 0.014), depression (OR = 5.45 95 % CI: 2.49,11.94; p < 0.001), a history of suicide (OR = 3.56; 95 % CI: 1.72,7.38; p = 0.001), and illness-related shame (OR = 2.76; 95 % CI: 2.17,3.52; p < 0.001) were risk factors for anxiety.
This meta-analysis showed that female, unmarried, low socioeconomic status, education level below senior high school, a history of trauma, monotherapy, AED-induced psychiatric side effects, depression, a history of suicide, and shame were risk factors for anxiety in PWE. However, further research is needed to determine the effect of other potential risk factors on anxiety in PWE. In addition, most of the studies included in this meta-analysis were not uniform in scale, and the risk factors were not comprehensive; therefore, larger prospective studies in different countries are needed to further investigate these risk factors.]]></description><subject>Anxiety</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - etiology</subject><subject>Epilepsy</subject><subject>Epilepsy - complications</subject><subject>Epilepsy - epidemiology</subject><subject>Epilepsy - psychology</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Quality of Life - psychology</subject><subject>Risk Factors</subject><issn>1525-5050</issn><issn>1525-5069</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQx4MotlY_gSA5etmabJptVvBQii8oCKLnkMeEpm531yRV99u7tdWjpxmG_4P5IXROyZgSWlytxh1oWI5zkk_6S1kU_AANKc95xklRHv7tnAzQSYwrQijljB6jAROsEFMxHaL5s49v2CmTmhCxawJW9ZeH1GFf41YlD3WK-NOnJYbWV9DG7hrP8BqSylStqi76eIqOnKoinO3nCL3e3b7MH7LF0_3jfLbIDCNlypgpqWNghNZWKyc0sdbSkk74FKzRjijOJ9ZYooxxhEyd1ZZqJkooeCkUsBG63OW2oXnfQExy7aOBqlI1NJso8zIXXBR9Si9lO6kJTYwBnGyDX6vQSUrklp5cyR96cktP7uj1rot9wUavwf55fnH1gpudAPo3PzwEGU1PyID1AUyStvH_FnwDQKuC1Q</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Niu, Cailang</creator><creator>Li, Penghong</creator><creator>Du, Xueqing</creator><creator>Zhao, Mina</creator><creator>Wang, Haobo</creator><creator>Yang, Debo</creator><creator>Wu, Maolin</creator><creator>Jing, Wei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202404</creationdate><title>Risk factors for anxiety in patients with epilepsy: A meta-analysis</title><author>Niu, Cailang ; Li, Penghong ; Du, Xueqing ; Zhao, Mina ; Wang, Haobo ; Yang, Debo ; Wu, Maolin ; Jing, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-3c91f3ec8bbdbaf8b0ddd191457edcbf0a554dcd0accf007fdbd1b389e6598ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety - etiology</topic><topic>Epilepsy</topic><topic>Epilepsy - complications</topic><topic>Epilepsy - epidemiology</topic><topic>Epilepsy - psychology</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Quality of Life - psychology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niu, Cailang</creatorcontrib><creatorcontrib>Li, Penghong</creatorcontrib><creatorcontrib>Du, Xueqing</creatorcontrib><creatorcontrib>Zhao, Mina</creatorcontrib><creatorcontrib>Wang, Haobo</creatorcontrib><creatorcontrib>Yang, Debo</creatorcontrib><creatorcontrib>Wu, Maolin</creatorcontrib><creatorcontrib>Jing, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niu, Cailang</au><au>Li, Penghong</au><au>Du, Xueqing</au><au>Zhao, Mina</au><au>Wang, Haobo</au><au>Yang, Debo</au><au>Wu, Maolin</au><au>Jing, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for anxiety in patients with epilepsy: A meta-analysis</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2024-04</date><risdate>2024</risdate><volume>153</volume><spage>109665</spage><pages>109665-</pages><artnum>109665</artnum><issn>1525-5050</issn><issn>1525-5069</issn><eissn>1525-5069</eissn><abstract><![CDATA[•The first meta-analysis of risk factors for anxiety for PWE.•Identified several factors associated with an increased risk of anxiety in PWE.•Further prospective cohort studies are needed to investigate risk factors of anxiety in PWE to help improve quality of life.
Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This meta-analysis was performed to identify potential risk factors for anxiety in PWE with the aim of reducing the incidence of anxiety and improving the quality of life among the individuals.
The PubMed, Embase and Cochrane Library databases were systematically searched up to July 2023 to find eligible original English studies. All the search results were reviewed based on our inclusion and exclusion criteria. We calculated the combined odds ratios (ORs), standard mean differences (SMDs) and their corresponding 95% confidence intervals (CIs) to evaluate the effect of the included risk factors on anxiety in PWE.
Twenty-four studies involving 5,403 PWE were ultimately included. The pooled results of our meta-analysis showed that female sex (OR = 1.67; 95 % CI: 1.30,2.15; p < 0.001), unmarried/divorced/widowed (OR = 0.83; 95 % CI: 0.72,0.96; p = 0.011), low socioeconomic status (OR = 0.47; 95 % CI: 0.33,0.67; p < 0.001), education levels below high school (OR = 1.74; 95 % CI: 1.36,2.23; p < 0.001), a history of trauma (OR = 2.53; 95 % CI: 1.69,3.78; p < 0.001), monotherapy (OR = 0.49; 95 % CI: 0.39,0.62; p < 0.001), AED-induced psychiatric side effects (OR = 2.45; 95 % CI: 1.20,4.98); p = 0.014), depression (OR = 5.45 95 % CI: 2.49,11.94; p < 0.001), a history of suicide (OR = 3.56; 95 % CI: 1.72,7.38; p = 0.001), and illness-related shame (OR = 2.76; 95 % CI: 2.17,3.52; p < 0.001) were risk factors for anxiety.
This meta-analysis showed that female, unmarried, low socioeconomic status, education level below senior high school, a history of trauma, monotherapy, AED-induced psychiatric side effects, depression, a history of suicide, and shame were risk factors for anxiety in PWE. However, further research is needed to determine the effect of other potential risk factors on anxiety in PWE. In addition, most of the studies included in this meta-analysis were not uniform in scale, and the risk factors were not comprehensive; therefore, larger prospective studies in different countries are needed to further investigate these risk factors.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38368787</pmid><doi>10.1016/j.yebeh.2024.109665</doi></addata></record> |
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| subjects | Anxiety Anxiety - epidemiology Anxiety - etiology Epilepsy Epilepsy - complications Epilepsy - epidemiology Epilepsy - psychology Humans Meta-analysis Quality of Life - psychology Risk Factors |
| title | Risk factors for anxiety in patients with epilepsy: A meta-analysis |
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