Crystallization inhibition in molecular liquids by polymers above the overlap concentration (c): Delay of the first nucleation event
Low concentration polymer additives can significantly alter crystal growth kinetics of molecular liquids and glasses. However, the effect of polymer concentration on nucleation kinetics remains poorly understood. Based on an experimentally determined first nucleation time (time to form the first cri...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2025-01, Vol.114 (1), p.82-88 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Song, Sichen Cui, Shuquan Sun, Changquan Calvin Lodge, Timothy P. Siegel, Ronald A. |
| description | Low concentration polymer additives can significantly alter crystal growth kinetics of molecular liquids and glasses. However, the effect of polymer concentration on nucleation kinetics remains poorly understood. Based on an experimentally determined first nucleation time (time to form the first critical nucleus, t0), we show that the polymer overlap concentration, c*, where polymer coils in the molecular liquid start to overlap with each other, is a critical polymer concentration for efficient inhibition of crystallization of a molecular liquid. The value of t0 is approximately equal to that of the neat molecular liquid when the polymer concentration, c, is below c*, but increases significantly when c > c*. This finding is relevant for effective polymer screening and performance prediction of engineered multicomponent amorphous materials, particularly pharmaceutical amorphous solid dispersions.
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| doi_str_mv | 10.1016/j.xphs.2024.02.011 |
| format | Article |
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| ispartof | Journal of pharmaceutical sciences, 2025-01, Vol.114 (1), p.82-88 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amorphous solid dispersion (ASD) Crystal growth Crystal nucleation Crystallization - methods Kinetics Physical stability Polymer overlap concentration (c) Polymers - chemistry |
| title | Crystallization inhibition in molecular liquids by polymers above the overlap concentration (c): Delay of the first nucleation event |
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