Monocyte distribution width (MDW): study of reference values in blood donors
Monocyte distribution width (MDW) is a new biomarker used as an early indicator of sepsis (ESId). It is often aids in the identification of patients who may develop sepsis. This study aims to establish the MDW reference interval (RI) within the healthy population of blood donors using EDTA-K as anti...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2024-05, Vol.62 (6), p.1133-1137 |
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| creator | García-Álvarez, Ana Posada Franco, Yolanda Martinez-Novillo González, Mercedes Hernández Álvarez, Elena Serrano García, Irene Sanz-Casla, María Teresa |
| description | Monocyte distribution width (MDW) is a new biomarker used as an early indicator of sepsis (ESId). It is often aids in the identification of patients who may develop sepsis. This study aims to establish the MDW reference interval (RI) within the healthy population of blood donors using EDTA-K
as anticoagulant. Many hospitals use this biomarker as a means of identifying patients who present to the hospital with sepsis.
A total of 274 samples obtained from healthy donors were analyzed. MDW measurements were taken within 2 h post-extraction. The RI was estimated using various statistical methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric and robust methods, along with the Harrell-Davis bootstrap method applied to the entire sample.
The RI estimated through non-parametric method was 14.77 CI90 % (14.36-14.97)-21.13 CI90 % (20.89-21.68); RI using the robust method was 15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90 % (14.53-14.92)-21.14 CI90 % (20.88-21.40).
Based on clinical applicability, we recommend utilizing the RI derived from the non-parametric method, aligning with the CLSI recommendations. Furthermore, we consider that our results can be taken as a reference in other laboratories that serve a population similar to our study cohort. |
| doi_str_mv | 10.1515/cclm-2023-1495 |
| format | Article |
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as anticoagulant. Many hospitals use this biomarker as a means of identifying patients who present to the hospital with sepsis.
A total of 274 samples obtained from healthy donors were analyzed. MDW measurements were taken within 2 h post-extraction. The RI was estimated using various statistical methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric and robust methods, along with the Harrell-Davis bootstrap method applied to the entire sample.
The RI estimated through non-parametric method was 14.77 CI90 % (14.36-14.97)-21.13 CI90 % (20.89-21.68); RI using the robust method was 15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90 % (14.53-14.92)-21.14 CI90 % (20.88-21.40).
Based on clinical applicability, we recommend utilizing the RI derived from the non-parametric method, aligning with the CLSI recommendations. Furthermore, we consider that our results can be taken as a reference in other laboratories that serve a population similar to our study cohort.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2023-1495</identifier><identifier>PMID: 38369513</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Adolescent ; Adult ; Aged ; anticoagulant EDTA-K ; Biomarkers ; Biomarkers - blood ; Blood ; Blood Donors ; donors ; Ethylenediaminetetraacetic acids ; Female ; Hematology ; Hospitals ; Humans ; Male ; Medical diagnosis ; Middle Aged ; monocyte distribution width (MDW) ; Monocytes ; Monocytes - cytology ; Nonparametric statistics ; Patients ; Population studies ; reference interval ; Reference Values ; Robustness ; Sepsis ; Sepsis - blood ; Sepsis - diagnosis ; Statistical analysis ; Statistical methods ; Young Adult</subject><ispartof>Clinical chemistry and laboratory medicine, 2024-05, Vol.62 (6), p.1133-1137</ispartof><rights>2024 the author(s), published by De Gruyter, Berlin/Boston.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c372t-871d8fb5b2e7a2731669fc46aadc969315a4383edd09280919f50cbf5b55a9223</cites><orcidid>0000-0003-2386-7128 ; 0000-0002-0451-7184 ; 0009-0000-2854-6919 ; 0000-0001-7184-5447 ; 0000-0002-9184-3497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2023-1495/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2023-1495/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38369513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Álvarez, Ana</creatorcontrib><creatorcontrib>Posada Franco, Yolanda</creatorcontrib><creatorcontrib>Martinez-Novillo González, Mercedes</creatorcontrib><creatorcontrib>Hernández Álvarez, Elena</creatorcontrib><creatorcontrib>Serrano García, Irene</creatorcontrib><creatorcontrib>Sanz-Casla, María Teresa</creatorcontrib><title>Monocyte distribution width (MDW): study of reference values in blood donors</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Monocyte distribution width (MDW) is a new biomarker used as an early indicator of sepsis (ESId). It is often aids in the identification of patients who may develop sepsis. This study aims to establish the MDW reference interval (RI) within the healthy population of blood donors using EDTA-K
as anticoagulant. Many hospitals use this biomarker as a means of identifying patients who present to the hospital with sepsis.
A total of 274 samples obtained from healthy donors were analyzed. MDW measurements were taken within 2 h post-extraction. The RI was estimated using various statistical methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric and robust methods, along with the Harrell-Davis bootstrap method applied to the entire sample.
The RI estimated through non-parametric method was 14.77 CI90 % (14.36-14.97)-21.13 CI90 % (20.89-21.68); RI using the robust method was 15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90 % (14.53-14.92)-21.14 CI90 % (20.88-21.40).
Based on clinical applicability, we recommend utilizing the RI derived from the non-parametric method, aligning with the CLSI recommendations. Furthermore, we consider that our results can be taken as a reference in other laboratories that serve a population similar to our study cohort.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>anticoagulant EDTA-K</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood Donors</subject><subject>donors</subject><subject>Ethylenediaminetetraacetic acids</subject><subject>Female</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>monocyte distribution width (MDW)</subject><subject>Monocytes</subject><subject>Monocytes - cytology</subject><subject>Nonparametric statistics</subject><subject>Patients</subject><subject>Population studies</subject><subject>reference interval</subject><subject>Reference Values</subject><subject>Robustness</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - diagnosis</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Young Adult</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtP3DAYRS1UVF7dskSWuhkWof78jCuxQNAWpEHdUHVpObYDQZmY2glo_j1Oh4dUdWUvzr2-PggdAjkBAeKLc_2qooSyCrgWW2gXOFMVZww-_L3zSkoKO2gv53tCQAiuPqIdVjOpBbBdtLyOQ3TrMWDf5TF1zTR2ccBPnR_v8OL64vfxV5zHya9xbHEKbUhhcAE_2n4KGXcDbvoYPfalJeUDtN3aPodPL-c--vX92835ZbX8-ePq_GxZOaboWNUKfN02oqFBWaoYSKlbx6W13mmpGQjLy8LgPdG0Jhp0K4hrWtEIYTWlbB8tNr0PKf4pO0az6rILfW-HEKdsaImJWnCY0c__oPdxSkNZZxjhSmktFBTqZEO5FHMu3zQPqVvZtDZAzOzZzJ7N7NnMnkvg6KV2albBv-GvYgtwugGebD-G5MNtmorl9P78_5sllVDi7BnZaYtn</recordid><startdate>20240527</startdate><enddate>20240527</enddate><creator>García-Álvarez, Ana</creator><creator>Posada Franco, Yolanda</creator><creator>Martinez-Novillo González, Mercedes</creator><creator>Hernández Álvarez, Elena</creator><creator>Serrano García, Irene</creator><creator>Sanz-Casla, María Teresa</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2386-7128</orcidid><orcidid>https://orcid.org/0000-0002-0451-7184</orcidid><orcidid>https://orcid.org/0009-0000-2854-6919</orcidid><orcidid>https://orcid.org/0000-0001-7184-5447</orcidid><orcidid>https://orcid.org/0000-0002-9184-3497</orcidid></search><sort><creationdate>20240527</creationdate><title>Monocyte distribution width (MDW): study of reference values in blood donors</title><author>García-Álvarez, Ana ; Posada Franco, Yolanda ; Martinez-Novillo González, Mercedes ; Hernández Álvarez, Elena ; Serrano García, Irene ; Sanz-Casla, María Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-871d8fb5b2e7a2731669fc46aadc969315a4383edd09280919f50cbf5b55a9223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>anticoagulant EDTA-K</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Blood Donors</topic><topic>donors</topic><topic>Ethylenediaminetetraacetic acids</topic><topic>Female</topic><topic>Hematology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>monocyte distribution width (MDW)</topic><topic>Monocytes</topic><topic>Monocytes - cytology</topic><topic>Nonparametric statistics</topic><topic>Patients</topic><topic>Population studies</topic><topic>reference interval</topic><topic>Reference Values</topic><topic>Robustness</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - diagnosis</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Álvarez, Ana</creatorcontrib><creatorcontrib>Posada Franco, Yolanda</creatorcontrib><creatorcontrib>Martinez-Novillo González, Mercedes</creatorcontrib><creatorcontrib>Hernández Álvarez, Elena</creatorcontrib><creatorcontrib>Serrano García, Irene</creatorcontrib><creatorcontrib>Sanz-Casla, María Teresa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Álvarez, Ana</au><au>Posada Franco, Yolanda</au><au>Martinez-Novillo González, Mercedes</au><au>Hernández Álvarez, Elena</au><au>Serrano García, Irene</au><au>Sanz-Casla, María Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monocyte distribution width (MDW): study of reference values in blood donors</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2024-05-27</date><risdate>2024</risdate><volume>62</volume><issue>6</issue><spage>1133</spage><epage>1137</epage><pages>1133-1137</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Monocyte distribution width (MDW) is a new biomarker used as an early indicator of sepsis (ESId). It is often aids in the identification of patients who may develop sepsis. This study aims to establish the MDW reference interval (RI) within the healthy population of blood donors using EDTA-K
as anticoagulant. Many hospitals use this biomarker as a means of identifying patients who present to the hospital with sepsis.
A total of 274 samples obtained from healthy donors were analyzed. MDW measurements were taken within 2 h post-extraction. The RI was estimated using various statistical methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric and robust methods, along with the Harrell-Davis bootstrap method applied to the entire sample.
The RI estimated through non-parametric method was 14.77 CI90 % (14.36-14.97)-21.13 CI90 % (20.89-21.68); RI using the robust method was 15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90 % (14.53-14.92)-21.14 CI90 % (20.88-21.40).
Based on clinical applicability, we recommend utilizing the RI derived from the non-parametric method, aligning with the CLSI recommendations. Furthermore, we consider that our results can be taken as a reference in other laboratories that serve a population similar to our study cohort.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>38369513</pmid><doi>10.1515/cclm-2023-1495</doi><tpages>05</tpages><orcidid>https://orcid.org/0000-0003-2386-7128</orcidid><orcidid>https://orcid.org/0000-0002-0451-7184</orcidid><orcidid>https://orcid.org/0009-0000-2854-6919</orcidid><orcidid>https://orcid.org/0000-0001-7184-5447</orcidid><orcidid>https://orcid.org/0000-0002-9184-3497</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged anticoagulant EDTA-K Biomarkers Biomarkers - blood Blood Blood Donors donors Ethylenediaminetetraacetic acids Female Hematology Hospitals Humans Male Medical diagnosis Middle Aged monocyte distribution width (MDW) Monocytes Monocytes - cytology Nonparametric statistics Patients Population studies reference interval Reference Values Robustness Sepsis Sepsis - blood Sepsis - diagnosis Statistical analysis Statistical methods Young Adult |
| title | Monocyte distribution width (MDW): study of reference values in blood donors |
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