In vivo treatment with calcilytic of CaSR knock‐in mice ameliorates renal phenotype reversing downregulation of the vasopressin‐AQP2 pathway

High concentrations of urinary calcium counteract vasopressin action via the activation of the Calcium‐Sensing Receptor (CaSR) expressed in the luminal membrane of the collecting duct cells, which impairs the trafficking of aquaporin‐2 (AQP2). In line with these findings, we provide evidence that, w...

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Veröffentlicht in:	The Journal of physiology 2024-07, Vol.602 (13), p.3207-3224
Hauptverfasser:	Ranieri, Marianna, Angelini, Ines, D'Agostino, Mariagrazia, Di Mise, Annarita, Centrone, Mariangela, Venneri, Maria, Ferrulli, Angela, Mastrodonato, Maria, Tamma, Grazia, Endo, Itsuro, Fukumoto, Seiji, Matsumoto, Toshio, Valenti, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AQP2 Aquaporin 2 Aquaporin 2 - genetics Aquaporin 2 - metabolism Aquaporins autosomal dominant hypocalcaemia Calcification calcilytic Calcinosis Calcium (urinary) Calcium - metabolism Calcium-sensing receptors CaSR Cell activation Collecting duct Down-Regulation Gene Knock-In Techniques Hypercalciuria Hypercalciuria - drug therapy Hypercalciuria - genetics Hypercalciuria - metabolism Hypocalcemia Hypoparathyroidism - congenital Kidney - drug effects Kidney - metabolism Kidney diseases Kidneys Male Membrane trafficking Mice Mice, Inbred C57BL microRNA Parathyroid hormone Phenotype Phenotypes Phosphorylation Reabsorption Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism Renal function Signal Transduction Vasopressin vasopressin type 2 receptor Vasopressins - metabolism
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