Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3
Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). Inhibition of STAT3 has been proposed as a reasonable strategy to suppress CRC. Gamabufotalin (Gam), an effective bioactive compound of ChanChu, has been used for cancer therapy due to its desirable...
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| Veröffentlicht in: | European journal of pharmacology 2024-03, Vol.966, p.176372-176372, Article 176372 |
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| container_title | European journal of pharmacology |
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| creator | Jiang, Nian Li, Sanhua Meng, Lingjie Zhang, Yao Yu, Changyan Xiao, Yi Liu, Yun |
| description | Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). Inhibition of STAT3 has been proposed as a reasonable strategy to suppress CRC. Gamabufotalin (Gam), an effective bioactive compound of ChanChu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, its effect on CRC is still unclear. In this study, we found that Gam significantly inhibited the CRC in vitro and vivo. Furthermore, Gam induced apoptosis to inhibit the viability of HCT-116 and HT-29 cell lines in dose-dependent manner by suppressing the transcription factor STAT3. In addition, Gam was also found to inhibit carcinogenesis of colitis-associated cancer (CAC) in AOM/DSS mice model by inhibiting STAT3. Our findings suggest that Gam may be an effective way to prevent occurrence and development of CRC and CAC. |
| doi_str_mv | 10.1016/j.ejphar.2024.176372 |
| format | Article |
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Inhibition of STAT3 has been proposed as a reasonable strategy to suppress CRC. Gamabufotalin (Gam), an effective bioactive compound of ChanChu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, its effect on CRC is still unclear. In this study, we found that Gam significantly inhibited the CRC in vitro and vivo. Furthermore, Gam induced apoptosis to inhibit the viability of HCT-116 and HT-29 cell lines in dose-dependent manner by suppressing the transcription factor STAT3. In addition, Gam was also found to inhibit carcinogenesis of colitis-associated cancer (CAC) in AOM/DSS mice model by inhibiting STAT3. Our findings suggest that Gam may be an effective way to prevent occurrence and development of CRC and CAC.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2024.176372</identifier><identifier>PMID: 38301817</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Colitis-associated colorectal cancer ; Colorectal cancer ; Gamabufotalin ; STAT3</subject><ispartof>European journal of pharmacology, 2024-03, Vol.966, p.176372-176372, Article 176372</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-fa434656b3ddc88daeadbbe28a5402c5c4f11e7e443f1636036081e12a958e303</cites><orcidid>0000-0003-1603-8946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2024.176372$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38301817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Nian</creatorcontrib><creatorcontrib>Li, Sanhua</creatorcontrib><creatorcontrib>Meng, Lingjie</creatorcontrib><creatorcontrib>Zhang, Yao</creatorcontrib><creatorcontrib>Yu, Changyan</creatorcontrib><creatorcontrib>Xiao, Yi</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><title>Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). 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Our findings suggest that Gam may be an effective way to prevent occurrence and development of CRC and CAC.</description><subject>Colitis-associated colorectal cancer</subject><subject>Colorectal cancer</subject><subject>Gamabufotalin</subject><subject>STAT3</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAQhkVJaLZJ3qAEH3PxViPJtnQJhNCmhUAP2Z6FLI8bLV7L0ciBvH29OOkxMDAwfP8M8zH2FfgWONTf9lvcT08ubQUXagtNLRvxiW1AN6bkDYgTtuEcVCmMMWfsC9Gec14ZUX1mZ1JLDhqaDcN7d3Dt3MfshjAWYXwKbchU-DiEHKh0RNEHl7E7jmJCv4CFd6PHVLSvBc3TlJAojH-LnNxIPoUphzgWvfM5puJxd7uTF-y0dwPh5Vs_Z39-fN_d_Swfft__urt9KL0EyGXvlFR1Vbey67zWnUPXtS0K7SrFha-86gGwQaVkD7Ws-VIaEIQzlUbJ5Tm7XvdOKT7PSNkeAnkcBjdinMkKI7RQxihYULWiPkWihL2dUji49GqB26Ngu7erYHsUbFfBS-zq7cLcHrD7H3o3ugA3K4DLny8BkyUfcNHVhaM828Xw8YV_9f6Ppw</recordid><startdate>20240305</startdate><enddate>20240305</enddate><creator>Jiang, Nian</creator><creator>Li, Sanhua</creator><creator>Meng, Lingjie</creator><creator>Zhang, Yao</creator><creator>Yu, Changyan</creator><creator>Xiao, Yi</creator><creator>Liu, Yun</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1603-8946</orcidid></search><sort><creationdate>20240305</creationdate><title>Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3</title><author>Jiang, Nian ; Li, Sanhua ; Meng, Lingjie ; Zhang, Yao ; Yu, Changyan ; Xiao, Yi ; Liu, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-fa434656b3ddc88daeadbbe28a5402c5c4f11e7e443f1636036081e12a958e303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Colitis-associated colorectal cancer</topic><topic>Colorectal cancer</topic><topic>Gamabufotalin</topic><topic>STAT3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Nian</creatorcontrib><creatorcontrib>Li, Sanhua</creatorcontrib><creatorcontrib>Meng, Lingjie</creatorcontrib><creatorcontrib>Zhang, Yao</creatorcontrib><creatorcontrib>Yu, Changyan</creatorcontrib><creatorcontrib>Xiao, Yi</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Nian</au><au>Li, Sanhua</au><au>Meng, Lingjie</au><au>Zhang, Yao</au><au>Yu, Changyan</au><au>Xiao, Yi</au><au>Liu, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2024-03-05</date><risdate>2024</risdate><volume>966</volume><spage>176372</spage><epage>176372</epage><pages>176372-176372</pages><artnum>176372</artnum><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Constitutive activation of STAT3 plays important role in the pathogenesis of colorectal cancer (CRC). 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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Colitis-associated colorectal cancer Colorectal cancer Gamabufotalin STAT3 |
| title | Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3 |
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