The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity
Influenza viruses escape immunity owing to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. We found that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affi...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2024-02, Vol.383 (6684), p.eadg0564 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6684 |
| container_start_page | eadg0564 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 383 |
| creator | Sharma, Pankaj Zhang, Xiaolong Ly, Kevin Zhang, Yuxiang Hu, Yu Ye, Adam Yongxin Hu, Jianqiao Kim, Ji Hyung Lou, Mumeng Wang, Chong Celuzza, Quinton Kondo, Yuji Furukawa, Keiko Bundle, David R Furukawa, Koichi Alt, Frederick W Winau, Florian |
| description | Influenza viruses escape immunity owing to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. We found that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affinity antibodies. Mechanistically, Gb3 bound and disengaged CD19 from its chaperone CD81, permitting CD19 to translocate to the B cell receptor complex to trigger signaling. Moreover, Gb3 regulated major histocompatibility complex class II expression to increase diversity of T follicular helper and GC B cells reactive with subdominant epitopes. In influenza infection, elevating Gb3, either endogenously or exogenously, promoted broadly reactive antibody responses and cross-protection. These data demonstrate that Gb3 determines the affinity and breadth of B cell immunity and has potential as a vaccine adjuvant. |
| doi_str_mv | 10.1126/science.adg0564 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2928245573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2926620254</sourcerecordid><originalsourceid>FETCH-LOGICAL-c279t-6233ebe4a5c720dec04e9fe8fedb15bfc2a1911d76c74943cc3616e2552d86483</originalsourceid><addsrcrecordid>eNpdkL1PwzAQxS0EoqUws6FILCyh_k4yQsWXVImlzMGxL8VVEhc7Qep_j0sDA8PpTrrfPb17CF0SfEsIlfOgLXQabpVZYyH5EZoSXIi0oJgdoynGTKY5zsQEnYWwwTjuCnaKJixnoiBETNH76gOSxm6tSdaNq1zvrXJh12jwqrUGkq13reshJGvwre1Uk2joevDJfRyaJvEQtq4LEVCdidXbL-sjZdt26Gy_O0cntWoCXIx9ht4eH1aL53T5-vSyuFummmZFn0rKGFTAldAZxQY05lDUkNdgKiKqWlNFomOTSZ3xgjOtmSQSqBDU5JLnbIZuDrrR8OcAoS9bG_YOVQduCCUtaE65EBmL6PU_dOMGH1_7oaSkmAoeqfmB0t6F4KEut962yu9Kgst9-OUYfjmGHy-uRt2hasH88b9ps2_0GIOJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2926620254</pqid></control><display><type>article</type><title>The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity</title><source>American Association for the Advancement of Science</source><creator>Sharma, Pankaj ; Zhang, Xiaolong ; Ly, Kevin ; Zhang, Yuxiang ; Hu, Yu ; Ye, Adam Yongxin ; Hu, Jianqiao ; Kim, Ji Hyung ; Lou, Mumeng ; Wang, Chong ; Celuzza, Quinton ; Kondo, Yuji ; Furukawa, Keiko ; Bundle, David R ; Furukawa, Koichi ; Alt, Frederick W ; Winau, Florian</creator><creatorcontrib>Sharma, Pankaj ; Zhang, Xiaolong ; Ly, Kevin ; Zhang, Yuxiang ; Hu, Yu ; Ye, Adam Yongxin ; Hu, Jianqiao ; Kim, Ji Hyung ; Lou, Mumeng ; Wang, Chong ; Celuzza, Quinton ; Kondo, Yuji ; Furukawa, Keiko ; Bundle, David R ; Furukawa, Koichi ; Alt, Frederick W ; Winau, Florian</creatorcontrib><description>Influenza viruses escape immunity owing to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. We found that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affinity antibodies. Mechanistically, Gb3 bound and disengaged CD19 from its chaperone CD81, permitting CD19 to translocate to the B cell receptor complex to trigger signaling. Moreover, Gb3 regulated major histocompatibility complex class II expression to increase diversity of T follicular helper and GC B cells reactive with subdominant epitopes. In influenza infection, elevating Gb3, either endogenously or exogenously, promoted broadly reactive antibody responses and cross-protection. These data demonstrate that Gb3 determines the affinity and breadth of B cell immunity and has potential as a vaccine adjuvant.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.adg0564</identifier><identifier>PMID: 38359115</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Affinity ; Animal models ; Antibodies ; Antigen presentation ; Antigenic determinants ; Antigens ; Antiviral agents ; Antiviral drugs ; B-cell receptor ; BCR-ABL protein ; CD19 antigen ; CD81 antigen ; Cell activation ; Communicable Diseases ; Cycles ; Degradation ; Disease control ; Epitopes ; Feedback (Response) ; FOXO1 protein ; Gene expression ; Genetic modification ; Germinal centers ; Globotriaosylceramide ; Glycoproteins ; Hemagglutinins ; Immune response ; Immune response (humoral) ; Immune system ; Immunity ; Infectious diseases ; Influenza ; Kinases ; Lipids ; Lymphocytes ; Lymphocytes B ; Maturation ; Public health ; Signal transduction ; Translocation ; Vaccines ; Viral infections ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 2024-02, Vol.383 (6684), p.eadg0564</ispartof><rights>Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c279t-6233ebe4a5c720dec04e9fe8fedb15bfc2a1911d76c74943cc3616e2552d86483</cites><orcidid>0000-0002-0583-1271 ; 0000-0002-6825-1442 ; 0000-0001-6785-2345 ; 0000-0002-3321-9784 ; 0000-0002-8361-8679 ; 0000-0002-8904-0775 ; 0000-0003-0497-3961 ; 0000-0002-9511-9383 ; 0000-0003-0729-3953 ; 0000-0002-1859-958X ; 0000-0002-1542-0740</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2871,2872,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38359115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Pankaj</creatorcontrib><creatorcontrib>Zhang, Xiaolong</creatorcontrib><creatorcontrib>Ly, Kevin</creatorcontrib><creatorcontrib>Zhang, Yuxiang</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Ye, Adam Yongxin</creatorcontrib><creatorcontrib>Hu, Jianqiao</creatorcontrib><creatorcontrib>Kim, Ji Hyung</creatorcontrib><creatorcontrib>Lou, Mumeng</creatorcontrib><creatorcontrib>Wang, Chong</creatorcontrib><creatorcontrib>Celuzza, Quinton</creatorcontrib><creatorcontrib>Kondo, Yuji</creatorcontrib><creatorcontrib>Furukawa, Keiko</creatorcontrib><creatorcontrib>Bundle, David R</creatorcontrib><creatorcontrib>Furukawa, Koichi</creatorcontrib><creatorcontrib>Alt, Frederick W</creatorcontrib><creatorcontrib>Winau, Florian</creatorcontrib><title>The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Influenza viruses escape immunity owing to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. We found that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affinity antibodies. Mechanistically, Gb3 bound and disengaged CD19 from its chaperone CD81, permitting CD19 to translocate to the B cell receptor complex to trigger signaling. Moreover, Gb3 regulated major histocompatibility complex class II expression to increase diversity of T follicular helper and GC B cells reactive with subdominant epitopes. In influenza infection, elevating Gb3, either endogenously or exogenously, promoted broadly reactive antibody responses and cross-protection. These data demonstrate that Gb3 determines the affinity and breadth of B cell immunity and has potential as a vaccine adjuvant.</description><subject>Affinity</subject><subject>Animal models</subject><subject>Antibodies</subject><subject>Antigen presentation</subject><subject>Antigenic determinants</subject><subject>Antigens</subject><subject>Antiviral agents</subject><subject>Antiviral drugs</subject><subject>B-cell receptor</subject><subject>BCR-ABL protein</subject><subject>CD19 antigen</subject><subject>CD81 antigen</subject><subject>Cell activation</subject><subject>Communicable Diseases</subject><subject>Cycles</subject><subject>Degradation</subject><subject>Disease control</subject><subject>Epitopes</subject><subject>Feedback (Response)</subject><subject>FOXO1 protein</subject><subject>Gene expression</subject><subject>Genetic modification</subject><subject>Germinal centers</subject><subject>Globotriaosylceramide</subject><subject>Glycoproteins</subject><subject>Hemagglutinins</subject><subject>Immune response</subject><subject>Immune response (humoral)</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Maturation</subject><subject>Public health</subject><subject>Signal transduction</subject><subject>Translocation</subject><subject>Vaccines</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkL1PwzAQxS0EoqUws6FILCyh_k4yQsWXVImlzMGxL8VVEhc7Qep_j0sDA8PpTrrfPb17CF0SfEsIlfOgLXQabpVZYyH5EZoSXIi0oJgdoynGTKY5zsQEnYWwwTjuCnaKJixnoiBETNH76gOSxm6tSdaNq1zvrXJh12jwqrUGkq13reshJGvwre1Uk2joevDJfRyaJvEQtq4LEVCdidXbL-sjZdt26Gy_O0cntWoCXIx9ht4eH1aL53T5-vSyuFummmZFn0rKGFTAldAZxQY05lDUkNdgKiKqWlNFomOTSZ3xgjOtmSQSqBDU5JLnbIZuDrrR8OcAoS9bG_YOVQduCCUtaE65EBmL6PU_dOMGH1_7oaSkmAoeqfmB0t6F4KEut962yu9Kgst9-OUYfjmGHy-uRt2hasH88b9ps2_0GIOJ</recordid><startdate>20240216</startdate><enddate>20240216</enddate><creator>Sharma, Pankaj</creator><creator>Zhang, Xiaolong</creator><creator>Ly, Kevin</creator><creator>Zhang, Yuxiang</creator><creator>Hu, Yu</creator><creator>Ye, Adam Yongxin</creator><creator>Hu, Jianqiao</creator><creator>Kim, Ji Hyung</creator><creator>Lou, Mumeng</creator><creator>Wang, Chong</creator><creator>Celuzza, Quinton</creator><creator>Kondo, Yuji</creator><creator>Furukawa, Keiko</creator><creator>Bundle, David R</creator><creator>Furukawa, Koichi</creator><creator>Alt, Frederick W</creator><creator>Winau, Florian</creator><general>The American Association for the Advancement of Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0583-1271</orcidid><orcidid>https://orcid.org/0000-0002-6825-1442</orcidid><orcidid>https://orcid.org/0000-0001-6785-2345</orcidid><orcidid>https://orcid.org/0000-0002-3321-9784</orcidid><orcidid>https://orcid.org/0000-0002-8361-8679</orcidid><orcidid>https://orcid.org/0000-0002-8904-0775</orcidid><orcidid>https://orcid.org/0000-0003-0497-3961</orcidid><orcidid>https://orcid.org/0000-0002-9511-9383</orcidid><orcidid>https://orcid.org/0000-0003-0729-3953</orcidid><orcidid>https://orcid.org/0000-0002-1859-958X</orcidid><orcidid>https://orcid.org/0000-0002-1542-0740</orcidid></search><sort><creationdate>20240216</creationdate><title>The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity</title><author>Sharma, Pankaj ; Zhang, Xiaolong ; Ly, Kevin ; Zhang, Yuxiang ; Hu, Yu ; Ye, Adam Yongxin ; Hu, Jianqiao ; Kim, Ji Hyung ; Lou, Mumeng ; Wang, Chong ; Celuzza, Quinton ; Kondo, Yuji ; Furukawa, Keiko ; Bundle, David R ; Furukawa, Koichi ; Alt, Frederick W ; Winau, Florian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-6233ebe4a5c720dec04e9fe8fedb15bfc2a1911d76c74943cc3616e2552d86483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Affinity</topic><topic>Animal models</topic><topic>Antibodies</topic><topic>Antigen presentation</topic><topic>Antigenic determinants</topic><topic>Antigens</topic><topic>Antiviral agents</topic><topic>Antiviral drugs</topic><topic>B-cell receptor</topic><topic>BCR-ABL protein</topic><topic>CD19 antigen</topic><topic>CD81 antigen</topic><topic>Cell activation</topic><topic>Communicable Diseases</topic><topic>Cycles</topic><topic>Degradation</topic><topic>Disease control</topic><topic>Epitopes</topic><topic>Feedback (Response)</topic><topic>FOXO1 protein</topic><topic>Gene expression</topic><topic>Genetic modification</topic><topic>Germinal centers</topic><topic>Globotriaosylceramide</topic><topic>Glycoproteins</topic><topic>Hemagglutinins</topic><topic>Immune response</topic><topic>Immune response (humoral)</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Maturation</topic><topic>Public health</topic><topic>Signal transduction</topic><topic>Translocation</topic><topic>Vaccines</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Pankaj</creatorcontrib><creatorcontrib>Zhang, Xiaolong</creatorcontrib><creatorcontrib>Ly, Kevin</creatorcontrib><creatorcontrib>Zhang, Yuxiang</creatorcontrib><creatorcontrib>Hu, Yu</creatorcontrib><creatorcontrib>Ye, Adam Yongxin</creatorcontrib><creatorcontrib>Hu, Jianqiao</creatorcontrib><creatorcontrib>Kim, Ji Hyung</creatorcontrib><creatorcontrib>Lou, Mumeng</creatorcontrib><creatorcontrib>Wang, Chong</creatorcontrib><creatorcontrib>Celuzza, Quinton</creatorcontrib><creatorcontrib>Kondo, Yuji</creatorcontrib><creatorcontrib>Furukawa, Keiko</creatorcontrib><creatorcontrib>Bundle, David R</creatorcontrib><creatorcontrib>Furukawa, Koichi</creatorcontrib><creatorcontrib>Alt, Frederick W</creatorcontrib><creatorcontrib>Winau, Florian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Pankaj</au><au>Zhang, Xiaolong</au><au>Ly, Kevin</au><au>Zhang, Yuxiang</au><au>Hu, Yu</au><au>Ye, Adam Yongxin</au><au>Hu, Jianqiao</au><au>Kim, Ji Hyung</au><au>Lou, Mumeng</au><au>Wang, Chong</au><au>Celuzza, Quinton</au><au>Kondo, Yuji</au><au>Furukawa, Keiko</au><au>Bundle, David R</au><au>Furukawa, Koichi</au><au>Alt, Frederick W</au><au>Winau, Florian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2024-02-16</date><risdate>2024</risdate><volume>383</volume><issue>6684</issue><spage>eadg0564</spage><pages>eadg0564-</pages><issn>0036-8075</issn><issn>1095-9203</issn><eissn>1095-9203</eissn><abstract>Influenza viruses escape immunity owing to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. We found that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affinity antibodies. Mechanistically, Gb3 bound and disengaged CD19 from its chaperone CD81, permitting CD19 to translocate to the B cell receptor complex to trigger signaling. Moreover, Gb3 regulated major histocompatibility complex class II expression to increase diversity of T follicular helper and GC B cells reactive with subdominant epitopes. In influenza infection, elevating Gb3, either endogenously or exogenously, promoted broadly reactive antibody responses and cross-protection. These data demonstrate that Gb3 determines the affinity and breadth of B cell immunity and has potential as a vaccine adjuvant.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>38359115</pmid><doi>10.1126/science.adg0564</doi><orcidid>https://orcid.org/0000-0002-0583-1271</orcidid><orcidid>https://orcid.org/0000-0002-6825-1442</orcidid><orcidid>https://orcid.org/0000-0001-6785-2345</orcidid><orcidid>https://orcid.org/0000-0002-3321-9784</orcidid><orcidid>https://orcid.org/0000-0002-8361-8679</orcidid><orcidid>https://orcid.org/0000-0002-8904-0775</orcidid><orcidid>https://orcid.org/0000-0003-0497-3961</orcidid><orcidid>https://orcid.org/0000-0002-9511-9383</orcidid><orcidid>https://orcid.org/0000-0003-0729-3953</orcidid><orcidid>https://orcid.org/0000-0002-1859-958X</orcidid><orcidid>https://orcid.org/0000-0002-1542-0740</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2024-02, Vol.383 (6684), p.eadg0564 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2928245573 |
| source | American Association for the Advancement of Science |
| subjects | Affinity Animal models Antibodies Antigen presentation Antigenic determinants Antigens Antiviral agents Antiviral drugs B-cell receptor BCR-ABL protein CD19 antigen CD81 antigen Cell activation Communicable Diseases Cycles Degradation Disease control Epitopes Feedback (Response) FOXO1 protein Gene expression Genetic modification Germinal centers Globotriaosylceramide Glycoproteins Hemagglutinins Immune response Immune response (humoral) Immune system Immunity Infectious diseases Influenza Kinases Lipids Lymphocytes Lymphocytes B Maturation Public health Signal transduction Translocation Vaccines Viral infections Viruses |
| title | The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T13%3A27%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20lipid%20globotriaosylceramide%20promotes%20germinal%20center%20B%20cell%20responses%20and%20antiviral%20immunity&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Sharma,%20Pankaj&rft.date=2024-02-16&rft.volume=383&rft.issue=6684&rft.spage=eadg0564&rft.pages=eadg0564-&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.adg0564&rft_dat=%3Cproquest_cross%3E2926620254%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2926620254&rft_id=info:pmid/38359115&rfr_iscdi=true |