LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors

In the central nervous system, noradrenaline transmission controls the degree to which we are awake, alert, and attentive. Aberrant noradrenaline transmission is associated with pathological forms of hyper- and hypo-arousal that present in numerous neuropsychiatric disorders often associated with dy...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2024-05, Vol.49 (6), p.1014-1023
Hauptverfasser:	Gugel, Aleigha, Ingebretsen, Erik A, Hake, Holly S, Gantz, Stephanie C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - pharmacology Adrenergic receptors Animals Arousal Brain slice preparation c-Fos protein Calcium channels Calcium channels (voltage-gated) Central nervous system Channel gating Clonidine Dorsal Raphe Nucleus - drug effects Dorsal Raphe Nucleus - metabolism Dorsal Raphe Nucleus - physiology Excitability Excitatory postsynaptic potentials Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female Inhibition Locus coeruleus Locus Coeruleus - drug effects Locus Coeruleus - physiology Male Mental disorders Mice Mice, Inbred C57BL Mice, Transgenic Neurons Norepinephrine Norepinephrine - metabolism Optogenetics Potassium channels (inwardly-rectifying) Potassium conductance Presynapse Receptors, Adrenergic, alpha-2 - drug effects Receptors, Adrenergic, alpha-2 - metabolism Receptors, Adrenergic, alpha-2 - physiology Serotonergic Neurons - drug effects Serotonergic Neurons - physiology Serotonin Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology
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