A Facile and Green Approach for the Preparation of Amine-Functionalized Poly(ethylene glycol) by Reducing Poly(ethylene glycol) Azide with Dithiothreitol

A Facile and Green Approach for the Preparation of Amine-Functionalized Poly(ethylene glycol) by Reducing Poly(ethylene glycol) Azide with Dithiothreitol

A facile and green approach for the preparation of PEG n -NH2s from PEG n -N3s in water with DTT as the reduction reagent has been developed, avoiding the introduction of metal ions and difficulties in purification compared to the traditional synthesis process of PEG n -NH2s. A series of high-purity...

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Veröffentlicht in:Biomacromolecules 2024-03, Vol.25 (3), p.1972-1977
Hauptverfasser: Zhang, Xuemei, Geng, Chao, Fu, Yang, Lv, Zhen, Wei, Zhonglin, Wang, Hongda, Wang, Shixue
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container_end_page 1977
container_issue 3
container_start_page 1972
container_title Biomacromolecules
container_volume 25
creator Zhang, Xuemei
Geng, Chao
Fu, Yang
Lv, Zhen
Wei, Zhonglin
Wang, Hongda
Wang, Shixue
description A facile and green approach for the preparation of PEG n -NH2s from PEG n -N3s in water with DTT as the reduction reagent has been developed, avoiding the introduction of metal ions and difficulties in purification compared to the traditional synthesis process of PEG n -NH2s. A series of high-purity linear and multiarm PEG n -NH2s with different molecular weights were synthesized, demonstrating the versatility of this method. Additionally, HS-PEG45-NH2 with high fidelity of thiol and amine was easily prepared through the one-step two functional group conversion of N3-PEG45-S-S-PEG45-N3, and the PEG-based NH2-PEG@AuNPs were also prepared. This technology will promote the application of PEG n -NH2s in the fields of medicine and biomaterials.
doi_str_mv 10.1021/acs.biomac.3c01370
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title A Facile and Green Approach for the Preparation of Amine-Functionalized Poly(ethylene glycol) by Reducing Poly(ethylene glycol) Azide with Dithiothreitol
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