The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project
Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUC...
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| Veröffentlicht in: | Journal of attention disorders 2024-03, Vol.28 (5), p.722-739 |
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| creator | Carucci, Sara Zuddas, Alessandro Lampis, Angelico Man, Kenneth K. C. Balia, Carla Buitelaar, Jan Danckaerts, Marina Dittmann, Ralf W. Donno, Federica Falissard, Bruno Gagliano, Antonella Garas, Peter Häge, Alexander Hollis, Chris Inglis, Sarah K. Konrad, Kerstin Kovshoff, Hanna Liddle, Elizabeth McCarthy, Suzanne Neubert, Antje Nagy, Peter Rosenthal, Eric Sonuga-Barke, Edmund J. S. Wong, Ian C. K. Banaschewski, Tobias Coghill, David |
| description | Objective:
The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.
Method:
Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.
Results:
The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.
Conclusion:
Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth. |
| doi_str_mv | 10.1177/10870547241226726 |
| format | Article |
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The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.
Method:
Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.
Results:
The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.
Conclusion:
Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.</description><identifier>ISSN: 1087-0547</identifier><identifier>EISSN: 1557-1246</identifier><identifier>DOI: 10.1177/10870547241226726</identifier><identifier>PMID: 38366816</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><ispartof>Journal of attention disorders, 2024-03, Vol.28 (5), p.722-739</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-75e928f79853ecc46422e5c828202c2ec8102a4a1ba8ebd26d6fa4b9e3b51a2b3</cites><orcidid>0000-0001-5776-5555</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10870547241226726$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10870547241226726$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38366816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carucci, Sara</creatorcontrib><creatorcontrib>Zuddas, Alessandro</creatorcontrib><creatorcontrib>Lampis, Angelico</creatorcontrib><creatorcontrib>Man, Kenneth K. C.</creatorcontrib><creatorcontrib>Balia, Carla</creatorcontrib><creatorcontrib>Buitelaar, Jan</creatorcontrib><creatorcontrib>Danckaerts, Marina</creatorcontrib><creatorcontrib>Dittmann, Ralf W.</creatorcontrib><creatorcontrib>Donno, Federica</creatorcontrib><creatorcontrib>Falissard, Bruno</creatorcontrib><creatorcontrib>Gagliano, Antonella</creatorcontrib><creatorcontrib>Garas, Peter</creatorcontrib><creatorcontrib>Häge, Alexander</creatorcontrib><creatorcontrib>Hollis, Chris</creatorcontrib><creatorcontrib>Inglis, Sarah K.</creatorcontrib><creatorcontrib>Konrad, Kerstin</creatorcontrib><creatorcontrib>Kovshoff, Hanna</creatorcontrib><creatorcontrib>Liddle, Elizabeth</creatorcontrib><creatorcontrib>McCarthy, Suzanne</creatorcontrib><creatorcontrib>Neubert, Antje</creatorcontrib><creatorcontrib>Nagy, Peter</creatorcontrib><creatorcontrib>Rosenthal, Eric</creatorcontrib><creatorcontrib>Sonuga-Barke, Edmund J. S.</creatorcontrib><creatorcontrib>Wong, Ian C. K.</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Coghill, David</creatorcontrib><title>The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project</title><title>Journal of attention disorders</title><addtitle>J Atten Disord</addtitle><description>Objective:
The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.
Method:
Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.
Results:
The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.
Conclusion:
Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.</description><issn>1087-0547</issn><issn>1557-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxi0EoqXlAbggH8shrT1JbC-3dLP9I7VqhbrnyHEmu1kl9mI7h74PD4rLFi5IPc1o5vd9o9FHyBfOzjmX8oIzJVlZSCg4gJAg3pFjXpYy41CI96lP--wFOCKfQtgxlksp4SM5ylUuhOLimPx62iK9nfbaROp6eo9x-zzut2iHTkekztLHuUUf9UjvdZy9jkOaadvRS2eRVhukg6VVfVPT5XYYO4-HbdW5EYNBG8N3-gPDPMZAe-8mGtPBP3zt502g64BJ6Z0dDF31PZrEnVV1vV6uvtFH73Zpcko-9HoM-Pm1npD11eppeZPdPVzfLqu7zMACYiZLXIDq5UKVORpTiAIAS6NAAQMDaBRnoAvNW62w7UB0otdFu8C8LbmGNj8hZwffvXc_ZwyxmYb0wzhqi24OTbqioGA5FwnlB9R4F4LHvtn7YdL-ueGseQmn-S-cpPn6aj-3E3b_FH_TSMD5AQh6g83Ozd6md99w_A3yq5YO</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Carucci, Sara</creator><creator>Zuddas, Alessandro</creator><creator>Lampis, Angelico</creator><creator>Man, Kenneth K. C.</creator><creator>Balia, Carla</creator><creator>Buitelaar, Jan</creator><creator>Danckaerts, Marina</creator><creator>Dittmann, Ralf W.</creator><creator>Donno, Federica</creator><creator>Falissard, Bruno</creator><creator>Gagliano, Antonella</creator><creator>Garas, Peter</creator><creator>Häge, Alexander</creator><creator>Hollis, Chris</creator><creator>Inglis, Sarah K.</creator><creator>Konrad, Kerstin</creator><creator>Kovshoff, Hanna</creator><creator>Liddle, Elizabeth</creator><creator>McCarthy, Suzanne</creator><creator>Neubert, Antje</creator><creator>Nagy, Peter</creator><creator>Rosenthal, Eric</creator><creator>Sonuga-Barke, Edmund J. S.</creator><creator>Wong, Ian C. K.</creator><creator>Banaschewski, Tobias</creator><creator>Coghill, David</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5776-5555</orcidid></search><sort><creationdate>202403</creationdate><title>The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project</title><author>Carucci, Sara ; Zuddas, Alessandro ; Lampis, Angelico ; Man, Kenneth K. C. ; Balia, Carla ; Buitelaar, Jan ; Danckaerts, Marina ; Dittmann, Ralf W. ; Donno, Federica ; Falissard, Bruno ; Gagliano, Antonella ; Garas, Peter ; Häge, Alexander ; Hollis, Chris ; Inglis, Sarah K. ; Konrad, Kerstin ; Kovshoff, Hanna ; Liddle, Elizabeth ; McCarthy, Suzanne ; Neubert, Antje ; Nagy, Peter ; Rosenthal, Eric ; Sonuga-Barke, Edmund J. S. ; Wong, Ian C. K. ; Banaschewski, Tobias ; Coghill, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-75e928f79853ecc46422e5c828202c2ec8102a4a1ba8ebd26d6fa4b9e3b51a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carucci, Sara</creatorcontrib><creatorcontrib>Zuddas, Alessandro</creatorcontrib><creatorcontrib>Lampis, Angelico</creatorcontrib><creatorcontrib>Man, Kenneth K. C.</creatorcontrib><creatorcontrib>Balia, Carla</creatorcontrib><creatorcontrib>Buitelaar, Jan</creatorcontrib><creatorcontrib>Danckaerts, Marina</creatorcontrib><creatorcontrib>Dittmann, Ralf W.</creatorcontrib><creatorcontrib>Donno, Federica</creatorcontrib><creatorcontrib>Falissard, Bruno</creatorcontrib><creatorcontrib>Gagliano, Antonella</creatorcontrib><creatorcontrib>Garas, Peter</creatorcontrib><creatorcontrib>Häge, Alexander</creatorcontrib><creatorcontrib>Hollis, Chris</creatorcontrib><creatorcontrib>Inglis, Sarah K.</creatorcontrib><creatorcontrib>Konrad, Kerstin</creatorcontrib><creatorcontrib>Kovshoff, Hanna</creatorcontrib><creatorcontrib>Liddle, Elizabeth</creatorcontrib><creatorcontrib>McCarthy, Suzanne</creatorcontrib><creatorcontrib>Neubert, Antje</creatorcontrib><creatorcontrib>Nagy, Peter</creatorcontrib><creatorcontrib>Rosenthal, Eric</creatorcontrib><creatorcontrib>Sonuga-Barke, Edmund J. S.</creatorcontrib><creatorcontrib>Wong, Ian C. K.</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Coghill, David</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of attention disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carucci, Sara</au><au>Zuddas, Alessandro</au><au>Lampis, Angelico</au><au>Man, Kenneth K. C.</au><au>Balia, Carla</au><au>Buitelaar, Jan</au><au>Danckaerts, Marina</au><au>Dittmann, Ralf W.</au><au>Donno, Federica</au><au>Falissard, Bruno</au><au>Gagliano, Antonella</au><au>Garas, Peter</au><au>Häge, Alexander</au><au>Hollis, Chris</au><au>Inglis, Sarah K.</au><au>Konrad, Kerstin</au><au>Kovshoff, Hanna</au><au>Liddle, Elizabeth</au><au>McCarthy, Suzanne</au><au>Neubert, Antje</au><au>Nagy, Peter</au><au>Rosenthal, Eric</au><au>Sonuga-Barke, Edmund J. S.</au><au>Wong, Ian C. K.</au><au>Banaschewski, Tobias</au><au>Coghill, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project</atitle><jtitle>Journal of attention disorders</jtitle><addtitle>J Atten Disord</addtitle><date>2024-03</date><risdate>2024</risdate><volume>28</volume><issue>5</issue><spage>722</spage><epage>739</epage><pages>722-739</pages><issn>1087-0547</issn><eissn>1557-1246</eissn><abstract>Objective:
The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.
Method:
Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.
Results:
The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.
Conclusion:
Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>38366816</pmid><doi>10.1177/10870547241226726</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0001-5776-5555</orcidid></addata></record> |
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| ispartof | Journal of attention disorders, 2024-03, Vol.28 (5), p.722-739 |
| issn | 1087-0547 1557-1246 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2928240316 |
| source | SAGE Complete A-Z List |
| title | The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project |
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