Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin
Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, isolated from Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercial...
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| Veröffentlicht in: | Process biochemistry (1991) 2006-12, Vol.41 (12), p.2464-2467 |
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| container_end_page | 2467 |
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| container_issue | 12 |
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| container_title | Process biochemistry (1991) |
| container_volume | 41 |
| creator | Tatineni, Radhika Doddapaneni, Kiran Kumar Dalavayi, Sailasree Kulkarni, Santosh M. Mangamoori, Lakshmi Narasu |
| description | Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, isolated from
Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of
Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercialization of the drug. An alternative approach by microbial bioconversion of arteannuin B to artemisinin was carried out by
Microbacterium trichotecenolyticum isolated from soil. Crude enzyme extract from cell free extracts were capable of microbial bioconversion of arteannuin B, the immediate precursor of artemisinin, to artemisinin. Attempts have been made to partially purify the proteins involved in bioconversion by ion exchange chromatography. Detection of artemisinin was done by thin layer chromatography, and quantified by HPLC. |
| doi_str_mv | 10.1016/j.procbio.2006.05.025 |
| format | Article |
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Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of
Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercialization of the drug. An alternative approach by microbial bioconversion of arteannuin B to artemisinin was carried out by
Microbacterium trichotecenolyticum isolated from soil. Crude enzyme extract from cell free extracts were capable of microbial bioconversion of arteannuin B, the immediate precursor of artemisinin, to artemisinin. Attempts have been made to partially purify the proteins involved in bioconversion by ion exchange chromatography. Detection of artemisinin was done by thin layer chromatography, and quantified by HPLC.</description><identifier>ISSN: 1359-5113</identifier><identifier>EISSN: 1873-3298</identifier><identifier>DOI: 10.1016/j.procbio.2006.05.025</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Antimalarial agent ; Arteannuin B ; Artemisia annua L ; Artemisinin ; Microbial bioconversion</subject><ispartof>Process biochemistry (1991), 2006-12, Vol.41 (12), p.2464-2467</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-405a17772989c3bd81738124edf3060b1e687e06945c0bfaa3d7a5ac0f5c44943</citedby><cites>FETCH-LOGICAL-c371t-405a17772989c3bd81738124edf3060b1e687e06945c0bfaa3d7a5ac0f5c44943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1359511306002315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Tatineni, Radhika</creatorcontrib><creatorcontrib>Doddapaneni, Kiran Kumar</creatorcontrib><creatorcontrib>Dalavayi, Sailasree</creatorcontrib><creatorcontrib>Kulkarni, Santosh M.</creatorcontrib><creatorcontrib>Mangamoori, Lakshmi Narasu</creatorcontrib><title>Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin</title><title>Process biochemistry (1991)</title><description>Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, isolated from
Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of
Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercialization of the drug. An alternative approach by microbial bioconversion of arteannuin B to artemisinin was carried out by
Microbacterium trichotecenolyticum isolated from soil. Crude enzyme extract from cell free extracts were capable of microbial bioconversion of arteannuin B, the immediate precursor of artemisinin, to artemisinin. Attempts have been made to partially purify the proteins involved in bioconversion by ion exchange chromatography. Detection of artemisinin was done by thin layer chromatography, and quantified by HPLC.</description><subject>Antimalarial agent</subject><subject>Arteannuin B</subject><subject>Artemisia annua L</subject><subject>Artemisinin</subject><subject>Microbial bioconversion</subject><issn>1359-5113</issn><issn>1873-3298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EEqXwCUhZsUsYx3GcrBBUvKQiNrA2jjMRrhK72C5S-Xpc2j2reejeq5lDyCWFggKtr1fF2jvdGVeUAHUBvICSH5EZbQTLWdk2x6lnvM05peyUnIWwAmCUUpiRjxejveuUjujNZsqiN_rTRdRo3biNRqcd2p_thNmEvVER-6RRNgzOTyoaZzM3ZMpHVNZujM3usuj-5skEY409JyeDGgNeHOqcvD_cvy2e8uXr4_PidplrJmjMK-CKCiHSta1mXd9QwRpaVtgPDGroKNaNQKjbimvoBqVYLxRXGgauq6qt2Jxc7XMTi68NhijTARrHUVl0myDLthQ155CEfC9Mf4fgcZBrbyblt5KC3PGUK3ngKXc8JXCZeCbfzd6H6Ytvg14GbdDqRMWjjrJ35p-EX1b9g5Y</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Tatineni, Radhika</creator><creator>Doddapaneni, Kiran Kumar</creator><creator>Dalavayi, Sailasree</creator><creator>Kulkarni, Santosh M.</creator><creator>Mangamoori, Lakshmi Narasu</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20061201</creationdate><title>Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin</title><author>Tatineni, Radhika ; Doddapaneni, Kiran Kumar ; Dalavayi, Sailasree ; Kulkarni, Santosh M. ; Mangamoori, Lakshmi Narasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-405a17772989c3bd81738124edf3060b1e687e06945c0bfaa3d7a5ac0f5c44943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antimalarial agent</topic><topic>Arteannuin B</topic><topic>Artemisia annua L</topic><topic>Artemisinin</topic><topic>Microbial bioconversion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tatineni, Radhika</creatorcontrib><creatorcontrib>Doddapaneni, Kiran Kumar</creatorcontrib><creatorcontrib>Dalavayi, Sailasree</creatorcontrib><creatorcontrib>Kulkarni, Santosh M.</creatorcontrib><creatorcontrib>Mangamoori, Lakshmi Narasu</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Process biochemistry (1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tatineni, Radhika</au><au>Doddapaneni, Kiran Kumar</au><au>Dalavayi, Sailasree</au><au>Kulkarni, Santosh M.</au><au>Mangamoori, Lakshmi Narasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin</atitle><jtitle>Process biochemistry (1991)</jtitle><date>2006-12-01</date><risdate>2006</risdate><volume>41</volume><issue>12</issue><spage>2464</spage><epage>2467</epage><pages>2464-2467</pages><issn>1359-5113</issn><eissn>1873-3298</eissn><abstract>Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, isolated from
Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of
Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercialization of the drug. An alternative approach by microbial bioconversion of arteannuin B to artemisinin was carried out by
Microbacterium trichotecenolyticum isolated from soil. Crude enzyme extract from cell free extracts were capable of microbial bioconversion of arteannuin B, the immediate precursor of artemisinin, to artemisinin. Attempts have been made to partially purify the proteins involved in bioconversion by ion exchange chromatography. Detection of artemisinin was done by thin layer chromatography, and quantified by HPLC.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.procbio.2006.05.025</doi><tpages>4</tpages></addata></record> |
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| ispartof | Process biochemistry (1991), 2006-12, Vol.41 (12), p.2464-2467 |
| issn | 1359-5113 1873-3298 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Antimalarial agent Arteannuin B Artemisia annua L Artemisinin Microbial bioconversion |
| title | Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin |
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