SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation

The potent immunomodulatory function of mesenchymal stem/stromal cells (MSCs) elicited by proinflammatory cytokines IFN-γ and TNF-α (IT) is critical to resolve inflammation and promote tissue repair. However, little is known about how the immunomodulatory capability of MSCs is related to their diffe...

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Veröffentlicht in:	Molecular therapy 2024-04, Vol.32 (4), p.1144-1157
Hauptverfasser:	Li, Yanan, Wang, Tingting, Li, Xiaolei, Li, Wen, Lei, Yan, Shang, Qianwen, Zheng, Zhiyuan, Fang, Jiankai, Cao, Lijuan, Yu, Daojiang, Meng, Zhenzhen, Zhang, Shengchao, Liu, Rui, Liu, Chunxiao, Xu, Chenchang, Ding, Yayun, Chen, Yongjing, Candi, Eleonora, Melino, Gerry, Wang, Ying, Shi, Yufang, Shao, Changshun
Format:	Artikel
Sprache:	eng
Schlagworte:	adipogenesis immunosuppression inflammatory cytokines mesenchymal stem cells mitochondrial biogenesis mitochondrial superoxide ROS SOD2
Online-Zugang:	Volltext
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