Effect of vascular geometry on haemodynamic changes in a carotid artery bifurcation using numerical simulation
The geometry of carotid bifurcation is a crucial contributing factor to the localization of atherosclerotic lesions. Currently, studies on carotid bifurcation geometry are limited to the region near to bifurcation. This study aimed to determine the influence of carotid bifurcation geometry on the bl...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2024-02, Vol.237, p.108153-108153, Article 108153 |
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| creator | Abhilash, H.N. Yanagita, Yoshiki Pai, Raghuvir Zuber, Mohammad Tamagawa, Masaaki K, Prakashini Kamath S, Ganesh R, Padmakumar Barboza, A.B.V. Rao, V.R.K. Khader, S.M. Abdul |
| description | The geometry of carotid bifurcation is a crucial contributing factor to the localization of atherosclerotic lesions. Currently, studies on carotid bifurcation geometry are limited to the region near to bifurcation. This study aimed to determine the influence of carotid bifurcation geometry on the blood flow using numerical simulations considering magnitude of haemodynamic parameters in the extended regions of carotid artery.
In the present study, haemodynamic analysis is carried out using the non-Newtonian viscosity model for patient-specific geometries consisting of both Left and Right carotid arteries. A 3D patient-specific geometric model is generated using MIMICS, and a numerical model is created using ANSYS.
The results obtained from patient-specific cases are compared. The influence of geometric features such as lumen diameter, bifurcation angle, and tortuosity on the haemodynamics parameters such as velocity, WSS, pressure, Oscillatory Shear Index (OSI), and Time-Averaged Wall Shear Stress (TAWSS) are compared.
The results demonstrate significant changes in the flow regime due to the geometric shape of the carotid artery. It is observed that the lower value of TAWSS occurs near the bifurcation region and carotid bulb region. In addition, the higher value of the (OSI) is observed in the Internal Carotid Artery (ICA) and the tortuous carotid artery region. However, it is also observed that apart from the bifurcation angle, other factors, such as tortuosity and area ratio, play a significant role in the flow dynamics of the carotid artery.
•The current haemodynamic study quantifies the flow variation due to geometric shape of carotid artery.•The disturbed flow in carotid artery can be evaluated through haemodynamic parameters such as Wall Shear Stress and Oscillatory Shear Index.•Results demonstrate the importance of geometric shape and its influence on generation of low wall shear stress.•Numerical investigation also reveals geometric parameters such as bifurcation angle, area ratio, tortuosity ratio play prime importance in evaluting atherosclerosis risk factors. |
| doi_str_mv | 10.1016/j.clineuro.2024.108153 |
| format | Article |
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In the present study, haemodynamic analysis is carried out using the non-Newtonian viscosity model for patient-specific geometries consisting of both Left and Right carotid arteries. A 3D patient-specific geometric model is generated using MIMICS, and a numerical model is created using ANSYS.
The results obtained from patient-specific cases are compared. The influence of geometric features such as lumen diameter, bifurcation angle, and tortuosity on the haemodynamics parameters such as velocity, WSS, pressure, Oscillatory Shear Index (OSI), and Time-Averaged Wall Shear Stress (TAWSS) are compared.
The results demonstrate significant changes in the flow regime due to the geometric shape of the carotid artery. It is observed that the lower value of TAWSS occurs near the bifurcation region and carotid bulb region. In addition, the higher value of the (OSI) is observed in the Internal Carotid Artery (ICA) and the tortuous carotid artery region. However, it is also observed that apart from the bifurcation angle, other factors, such as tortuosity and area ratio, play a significant role in the flow dynamics of the carotid artery.
•The current haemodynamic study quantifies the flow variation due to geometric shape of carotid artery.•The disturbed flow in carotid artery can be evaluated through haemodynamic parameters such as Wall Shear Stress and Oscillatory Shear Index.•Results demonstrate the importance of geometric shape and its influence on generation of low wall shear stress.•Numerical investigation also reveals geometric parameters such as bifurcation angle, area ratio, tortuosity ratio play prime importance in evaluting atherosclerosis risk factors.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2024.108153</identifier><identifier>PMID: 38350174</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Blood flow ; Boundary conditions ; Carotid arteries ; Carotid artery ; Carotid Bifurcation ; Fatalities ; Geometry ; Haemodynamics ; Hemodynamics ; Investigations ; Localization ; Mathematical models ; Oscillatory Shear Index ; Shear stress ; Simulation ; Stroke ; Transient ischemic attack ; Vascular geometry ; Veins & arteries ; Velocity ; Viscosity ; Wall Shear Stress</subject><ispartof>Clinical neurology and neurosurgery, 2024-02, Vol.237, p.108153-108153, Article 108153</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><rights>2024. The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c391t-6a6fe61c5a1c621c43f0bd923faa3408d59df36d3e130e18d06f786be6c1f7993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3048759135?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38350174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abhilash, H.N.</creatorcontrib><creatorcontrib>Yanagita, Yoshiki</creatorcontrib><creatorcontrib>Pai, Raghuvir</creatorcontrib><creatorcontrib>Zuber, Mohammad</creatorcontrib><creatorcontrib>Tamagawa, Masaaki</creatorcontrib><creatorcontrib>K, Prakashini</creatorcontrib><creatorcontrib>Kamath S, Ganesh</creatorcontrib><creatorcontrib>R, Padmakumar</creatorcontrib><creatorcontrib>Barboza, A.B.V.</creatorcontrib><creatorcontrib>Rao, V.R.K.</creatorcontrib><creatorcontrib>Khader, S.M. Abdul</creatorcontrib><title>Effect of vascular geometry on haemodynamic changes in a carotid artery bifurcation using numerical simulation</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>The geometry of carotid bifurcation is a crucial contributing factor to the localization of atherosclerotic lesions. Currently, studies on carotid bifurcation geometry are limited to the region near to bifurcation. This study aimed to determine the influence of carotid bifurcation geometry on the blood flow using numerical simulations considering magnitude of haemodynamic parameters in the extended regions of carotid artery.
In the present study, haemodynamic analysis is carried out using the non-Newtonian viscosity model for patient-specific geometries consisting of both Left and Right carotid arteries. A 3D patient-specific geometric model is generated using MIMICS, and a numerical model is created using ANSYS.
The results obtained from patient-specific cases are compared. The influence of geometric features such as lumen diameter, bifurcation angle, and tortuosity on the haemodynamics parameters such as velocity, WSS, pressure, Oscillatory Shear Index (OSI), and Time-Averaged Wall Shear Stress (TAWSS) are compared.
The results demonstrate significant changes in the flow regime due to the geometric shape of the carotid artery. It is observed that the lower value of TAWSS occurs near the bifurcation region and carotid bulb region. In addition, the higher value of the (OSI) is observed in the Internal Carotid Artery (ICA) and the tortuous carotid artery region. However, it is also observed that apart from the bifurcation angle, other factors, such as tortuosity and area ratio, play a significant role in the flow dynamics of the carotid artery.
•The current haemodynamic study quantifies the flow variation due to geometric shape of carotid artery.•The disturbed flow in carotid artery can be evaluated through haemodynamic parameters such as Wall Shear Stress and Oscillatory Shear Index.•Results demonstrate the importance of geometric shape and its influence on generation of low wall shear stress.•Numerical investigation also reveals geometric parameters such as bifurcation angle, area ratio, tortuosity ratio play prime importance in evaluting atherosclerosis risk factors.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Blood flow</subject><subject>Boundary conditions</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Bifurcation</subject><subject>Fatalities</subject><subject>Geometry</subject><subject>Haemodynamics</subject><subject>Hemodynamics</subject><subject>Investigations</subject><subject>Localization</subject><subject>Mathematical models</subject><subject>Oscillatory Shear Index</subject><subject>Shear stress</subject><subject>Simulation</subject><subject>Stroke</subject><subject>Transient ischemic attack</subject><subject>Vascular geometry</subject><subject>Veins & arteries</subject><subject>Velocity</subject><subject>Viscosity</subject><subject>Wall Shear Stress</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9rHCEYh6WkNJu0XyEIufQyWx1n_HNrCZumEOilPYurrxuXGU11DOy3j8smOfSSk_D6_H6v-CB0RcmaEsq_7dd2ChFqTuue9EMbSjqyD2hFpeg7rrg8QyvCCOvkwMU5uihlTwhhjMtP6JxJNhIqhhWKG-_BLjh5_GSKrZPJeAdphiUfcIr4wcCc3CGaOVhsH0zcQcEhYoOtyWkJDpu8QGO3wddszRJaqJYQdzjWGXKwZsIlzK34ePUZffRmKvDl5bxEf283f27uuvvfP3_d_LjvLFN06bjhHji1o6GW99QOzJOtUz3zxrCBSDcq5xl3DCgjQKUj3AvJt8At9UIpdom-nnofc_pXoSx6DsXCNJkIqRbdq56PvRJCNPT6P3Sfao7tdZqRQYpRUTY2ip8om1MpGbx-zGE2-aAp0Ucjeq9fjeijEX0y0oJXL_V1O4N7i70qaMD3EwDtP54CZF1sgGjBhdzMaJfCezueAbF9oYQ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Abhilash, H.N.</creator><creator>Yanagita, Yoshiki</creator><creator>Pai, Raghuvir</creator><creator>Zuber, Mohammad</creator><creator>Tamagawa, Masaaki</creator><creator>K, Prakashini</creator><creator>Kamath S, Ganesh</creator><creator>R, Padmakumar</creator><creator>Barboza, A.B.V.</creator><creator>Rao, V.R.K.</creator><creator>Khader, S.M. 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Abdul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vascular geometry on haemodynamic changes in a carotid artery bifurcation using numerical simulation</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>237</volume><spage>108153</spage><epage>108153</epage><pages>108153-108153</pages><artnum>108153</artnum><issn>0303-8467</issn><eissn>1872-6968</eissn><abstract>The geometry of carotid bifurcation is a crucial contributing factor to the localization of atherosclerotic lesions. Currently, studies on carotid bifurcation geometry are limited to the region near to bifurcation. This study aimed to determine the influence of carotid bifurcation geometry on the blood flow using numerical simulations considering magnitude of haemodynamic parameters in the extended regions of carotid artery.
In the present study, haemodynamic analysis is carried out using the non-Newtonian viscosity model for patient-specific geometries consisting of both Left and Right carotid arteries. A 3D patient-specific geometric model is generated using MIMICS, and a numerical model is created using ANSYS.
The results obtained from patient-specific cases are compared. The influence of geometric features such as lumen diameter, bifurcation angle, and tortuosity on the haemodynamics parameters such as velocity, WSS, pressure, Oscillatory Shear Index (OSI), and Time-Averaged Wall Shear Stress (TAWSS) are compared.
The results demonstrate significant changes in the flow regime due to the geometric shape of the carotid artery. It is observed that the lower value of TAWSS occurs near the bifurcation region and carotid bulb region. In addition, the higher value of the (OSI) is observed in the Internal Carotid Artery (ICA) and the tortuous carotid artery region. However, it is also observed that apart from the bifurcation angle, other factors, such as tortuosity and area ratio, play a significant role in the flow dynamics of the carotid artery.
•The current haemodynamic study quantifies the flow variation due to geometric shape of carotid artery.•The disturbed flow in carotid artery can be evaluated through haemodynamic parameters such as Wall Shear Stress and Oscillatory Shear Index.•Results demonstrate the importance of geometric shape and its influence on generation of low wall shear stress.•Numerical investigation also reveals geometric parameters such as bifurcation angle, area ratio, tortuosity ratio play prime importance in evaluting atherosclerosis risk factors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38350174</pmid><doi>10.1016/j.clineuro.2024.108153</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Arteriosclerosis Atherosclerosis Blood flow Boundary conditions Carotid arteries Carotid artery Carotid Bifurcation Fatalities Geometry Haemodynamics Hemodynamics Investigations Localization Mathematical models Oscillatory Shear Index Shear stress Simulation Stroke Transient ischemic attack Vascular geometry Veins & arteries Velocity Viscosity Wall Shear Stress |
| title | Effect of vascular geometry on haemodynamic changes in a carotid artery bifurcation using numerical simulation |
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