Understanding hemoglobin contribution to high-dose methotrexate disposition—population pharmacokinetics in pediatric patients with hematological malignancies

Purpose The aim of the present study was to develop a population pharmacokinetic model for methotrexate (MTX) during high-dose treatment (HDMTX) in pediatric patients with acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL) and to describe the influence of variability factors. Method...

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Veröffentlicht in:	European journal of clinical pharmacology 2024-05, Vol.80 (5), p.697-705
Hauptverfasser:	Škorić, Biljana, Jovanović, Marija, Kuzmanović, Miloš, Miljković, Branislava, Vučićević, Katarina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Antimetabolites, Antineoplastic - therapeutic use Biomedical and Life Sciences Biomedicine Body weight Child Creatinine Female Hematologic Neoplasms - drug therapy Hemoglobin Humans Lymphatic leukemia Male Malignancy Methotrexate Non-Hodgkin's lymphoma Parameter estimation Patients Pediatrics Pharmacokinetics Pharmacology/Toxicology Population studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Renal function
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